Objective diagnosis of micrognathia in the fetus: the jaw index

Paladini, D.; Morra, T.; Teodoro, A.; Lamberti, A.; Tremolaterra, Fortunato; Martinelli, Pasquale

doi:10.1016/s0029-7844(98)00414-1

Cited by 87 publications

(124 citation statements)

References 10 publications

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“…33 Authors of retrospective studies have described objective modalities for monitoring jaw growth and detection of micrognathia and retrognathia with two-and three-dimensional prenatal ultrasound. [34][35][36][37][38][39][40] Paladini et al 41 developed a mandibular growth chart for the fetal mandible relative to biparietal diameter and proposed the jaw index as a more sensitive and specific mode of identifying micrognathia. However, these calculations are not routinely used.…”

Section: Prenatal Diagnosis Is Challengingmentioning

confidence: 99%

Robin Sequence: From Diagnosis to Development of an Effective Management Plan

et al. 2011

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The triad of micrognathia, glossoptosis, and resultant airway obstruction is known as Robin sequence (RS). Although RS is a well-recognized clinical entity, there is wide variability in the diagnosis and care of children born with RS. Systematic evaluations of treatments and clinical outcomes for children with RS are lacking despite the advances in clinical care over the past 20 years. We explore the pathogenesis, developmental and genetic models, morphology, and syndromes and malformations associated with RS. Current classification systems for RS do not account for the heterogeneity among infants with RS, and they do not allow for prediction of the optimal management course for an individual child. Although upper airway obstruction for some infants with RS can be treated adequately with positioning, other children may require a tracheostomy. Care must be customized for each patient with RS, and health care providers must understand the anatomy and mechanism of airway obstruction to develop an individualized treatment plan to improve breathing and achieve optimal growth and development. In this article we provide a comprehensive overview of evaluation strategies and therapeutic options for children born with RS. We also propose a conceptual treatment protocol to guide the provider who is caring for a child with RS. Pediatrics 2011;127:936-948

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Section: Prenatal Diagnosis Is Challengingmentioning

confidence: 99%

Robin Sequence: From Diagnosis to Development of an Effective Management Plan

et al. 2011

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“…2,12 Others have attempted to use mandibular measurements for this assessment. [13][14][15] Paladini and coworkers 15 applied a newborn parameter, the jaw index, to 262 fetuses without abnormalities between 12 and 37 weeks' gestation. 16 Their population of 198 fetuses with malformations included 11 with micrognathia.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional Ultrasonographic Presentation of Micrognathia

Lee

McNie

Chaiworapongsa

et al. 2002

Journal of Ultrasound in Medicine

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Objective. To present the variable appearance of micrognathia in fetuses by three-dimensional ultrasonography and to describe practical methods for analysis of these volume data. Methods. Threedimensional multiplanar imaging and surface-rendering techniques were used to show various syndromes and diagnostic approaches for the evaluation of fetal micrognathia. Results. Nine cases of fetal micrognathia are presented. Orthogonal multiplanar views were used to obtain a midsagittal facial profile. Examples of micrognathia include 3 cases of Pierre Robin sequence, cerebrocostomandibular syndrome, Cornelia de Lange syndrome, and hypochondrogenesis. Diagnostic pitfalls for micrognathia are also shown. Conclusions. Three-dimensional multiplanar imaging increases the likelihood that a true midline sagittal view of the facial profile is being analyzed. Surface rendering provides another way to qualitatively evaluate the fetal chin from different viewing perspectives. Three-dimensional ultrasonographic methods are useful adjuncts to the preliminary diagnostic impression from two-dimensional ultrasonography.

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“…Numerous studies using more standardized objective methods for measuring fetal jaw size and micrognathia have been performed [11,12,13,14,15,16,17,18,19,20]. Paladini et al [14] introduced the concept of a jaw index by defining growth curves and biometry in order to establish normal fetal jaw size and dimensions in utero.…”

Section: Micrognathiamentioning

confidence: 99%

“…Paladini et al [14] introduced the concept of a jaw index by defining growth curves and biometry in order to establish normal fetal jaw size and dimensions in utero. Two vectors of growth were calculated by measuring two diameters of the mandible at two different time periods, at 12 and again at 37 weeks.…”

Section: Micrognathiamentioning

confidence: 99%

Prenatal Identification of Pierre Robin Sequence: A Review of the Literature and Look towards the Future

Kaufman¹,

Cassady

Hyman³

et al. 2015

Fetal Diagn Ther

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Fetal ultrasonography is an important tool used to prenatally diagnose many craniofacial conditions. Pierre Robin sequence (PRS) is a rare congenital deformation characterized by micrognathia, glossoptosis, and airway obstruction. PRS can present as a perinatal emergency when the retropositioned tongue obstructs the airway leading to respiratory compromise. More predictable and reliable diagnostic studies could help the treating medical team as well as families prepare for these early airway emergencies. The medical literature was reviewed for different techniques used to prenatally diagnose PRS radiologically. We have reviewed these techniques and suggested a possible diagnostic pathway to consistently identify patients with PRS prenatally.

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Objective diagnosis of micrognathia in the fetus: the jaw index

Abstract: We demonstrated the linear relationship between mandibular growth and gestational age or BPD. In addition, we validated the jaw index as an objective tool for diagnosis of micrognathia in the fetus.

Cited by 87 publications

References 10 publications

Robin Sequence: From Diagnosis to Development of an Effective Management Plan

Robin Sequence: From Diagnosis to Development of an Effective Management Plan

Three-dimensional Ultrasonographic Presentation of Micrognathia

Prenatal Identification of Pierre Robin Sequence: A Review of the Literature and Look towards the Future

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