Objective Diagnosis of Alcohol Abuse: Compared Values of Carbohydrate‐Deficient Transferrin (CDT), γ‐Glutamyl Transferase (GGT), and Mean Corpuscular Volume (MCV)

Reynaud, Michel; Schellenberg, François; Loisequx‐Meunier, Marie‐Nadia; Schwan, Raymund; Maradeix, B; Planche, F.; Gillet, Claudine

doi:10.1111/j.1530-0277.2000.tb02111.x

Cited by 45 publications

(24 citation statements)

References 49 publications

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“…[3,15] The major signs of SAH include markedly elevated jaundice and concomitant coagulopathy. [16] In agreement with the previous reports in patients with liver disease, [17][18][19][20] high levels of MCV, the AST/ALT ratio, TBIL, and INR were observed in SAH. Therefore, it would be important and necessary to do more studies on the prognosis of Chinese patients with SAH.…”

Section: Discussionsupporting

confidence: 81%

Disease spectrum of alcoholic liver disease in beijing 302 hospital from 2002 to 2013: a large tertiary referral hospital experience from 7,422 patients

Huang¹,

Chang²,

Sun³

et al. 2017

Journal of Hepatology

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Section: Discussionsupporting

confidence: 81%

Disease spectrum of alcoholic liver disease in beijing 302 hospital from 2002 to 2013: a large tertiary referral hospital experience from 7,422 patients

Huang¹,

Chang²,

Sun³

et al. 2017

Journal of Hepatology

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“…Many heavy drinkers had a level of CDT<2.1%, but this is not necessarily a misclassification because this is usually found in 1 of 6 patients with excessive chronic ethanol consumption. 7 We found that a chronic ethanol consumption of ≥300 g per week is independently associated with a higher severity of the neurological deficit. There is not necessarily a causal relationship between ethanol consumption and stroke severity, but just a statistical association, that could be related to confounders that were not included in the analysis.…”

Section: Discussionmentioning

confidence: 71%

“…As the specificity of a CDT>2.5% for excessive chronic ethanol consumption is high, 7 there were probably <5% of heavy drinker misclassified. Many heavy drinkers had a level of CDT<2.1%, but this is not necessarily a misclassification because this is usually found in 1 of 6 patients with excessive chronic ethanol consumption.…”

Section: Discussionmentioning

confidence: 99%

Influence of Chronic Ethanol Consumption on the Neurological Severity in Patients With Acute Cerebral Ischemia

Ducroquet

Leys

Saabi

et al. 2013

Stroke

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Background and Purpose— We tested the hypothesis that excessive chronic ethanol consumption is associated with more severe ischemic strokes. Methods— We recruited patients with supratentorial cerebral ischemia within 48 hours of symptom onset. We defined heavy drinkers by a weekly consumption of ethanol of ≥300 g and severe strokes by a National Institutes of Health Stroke Scale score≥6. Results— Of 436 patients, 60 were heavy drinkers. Being a heavy drinker was independently associated with baseline National Institutes of Health Stroke Scale scores ≥6 (odds ratio, 2.35; 95% confidence interval, 1.12–5.26; P =0.023) at the logistic regression analysis. This result was not modified with the propensity analysis. Conclusion— An excessive chronic ethanol consumption is associated with higher baseline stroke severity.

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“…It is well-known that a combination of CDT and GGT, namely GGT-CDT, can have higher sensitivity than single markers alone in detecting excessive drinkers [16]. Although MCV is often included in the current standards of biomarkers for excessive drinking, sensitivity of MCV in detection of habitual drinkers is lower than those of GGT as demonstrated in several reports [17,18]. In the present study, the positive rates of %CDT and GGT in habitual heavy drinkers consuming more than 60 g of alcohol per day were 58.3% and 41.7%, respectively in all the heavy drinkers ( Figures 1 and 2); 58% and 44%, respectively, in males and 58% and 17%, respectively, in females.…”

Section: Discussionmentioning

confidence: 99%

Determination of Serum Carbohydrate-Deficient Transferrin (CDT) by the Nephelometric N Latex CDT Assay in Japanese Habitual Drinkers and Patients with Non-Alcoholic Liver Diseases

Seimiya¹

2013

J Alcoholism Drug Depend

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Background: Excessive alcohol consumption is a health risk that can lead to a variety of medical and social problems. Carbohydrate Deficient Transferrin (CDT) is now widely used for detection of chronic alcohol abuse and monitoring sobriety in alcoholics. We assessed the diagnostic performance of the direct immunoassay for %CDT (N Latex CDT) in Japanese habitual drinkers at their annual medical check-up. We also tested whether this direct assay is influenced by the presence of non-alcoholic liver disease including non-alcoholic steatohepatitis and HCVrelated hepatocellular carcinoma. Methods: We performed the N Latex CDT assay using a Siemens BN-II nephelometric analyzer to measure CDT concentration. The reference intervals of %CDT and gamma glutamyl transferase (GGT) activities were obtained based on their measurements in 160 apparently healthy nondrinkers. Habitual drinkers were divided into light drinkers (less than 40g ethanol/day) and heavy drinkers (more than 60g ethanol/day) Furthermore, %CDT levels in a total of 184 patients with non-alcoholic chronic liver diseases including Hepatitis C Virus (HCV) related liver cirrhosis, Non-Alcoholic Steatohepatitis (NASH) were determined. Results: In the heavy drinkers, the positive rates of %CDT and GGT were 58.3% and 41.7%, respectively. The combination assay of %CDT and GGT resulted in 75% sensitivity and 95% specificity. It was notable that 57% of GGT non-responders were detected by CDT measurements. The mean serum level of %CDT was not influenced by the presence of NASH, but was increased in patients with moderate-severe HCV-related liver cirrhosis. The %CDT levels were also high in patients with hepatocellular carcinoma with liver cirrhosis, but were not related to their tumor stages. Conclusions:The %CDT determined by automated N Latex CDT may be useful biomarker complementary to GGT to detect excessive habitual drinkers in Japan. However, caution should be taken to interpret the results in advanced non-alcoholic liver cirrhosis.

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Objective Diagnosis of Alcohol Abuse: Compared Values of Carbohydrate‐Deficient Transferrin (CDT), γ‐Glutamyl Transferase (GGT), and Mean Corpuscular Volume (MCV)

Abstract: Carbohydrate-deficient transferrin proves to be the best marker of alcohol abuse. It allows objective detection so that therapeutic action can be started early, which is easier and more effective than in alcohol dependence.

Cited by 45 publications

References 49 publications

Disease spectrum of alcoholic liver disease in beijing 302 hospital from 2002 to 2013: a large tertiary referral hospital experience from 7,422 patients

Disease spectrum of alcoholic liver disease in beijing 302 hospital from 2002 to 2013: a large tertiary referral hospital experience from 7,422 patients

Influence of Chronic Ethanol Consumption on the Neurological Severity in Patients With Acute Cerebral Ischemia

Determination of Serum Carbohydrate-Deficient Transferrin (CDT) by the Nephelometric N Latex CDT Assay in Japanese Habitual Drinkers and Patients with Non-Alcoholic Liver Diseases

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