Alcohol use disorder is argued to be a highly complex disorder influenced by a multitude of factors on different levels. Common research approaches fail to capture this breadth of interconnecting symptoms. To address this gap in theoretical assumptions and methodological approaches, we used a network analysis to assess the interplay of alcohol use disorder symptoms. We applied the analysis to two US-datasets, a population sample with 23,591 individuals and a clinical sample with 483 individuals seeking treatment for alcohol use disorder. First, using a Bayesian framework we investigated differences between clinical and population samples looking at the symptom interactions and underlying structure space. The clinical sample depicts less connections; those connections are additionally weaker. Second, for the population sample we assessed whether the interactions were measurement invariant across subgroups of external factors like age, gender, ethnicity and income. Interactions differed across all external factors. Distinct parameter estimates for subgroups should be considered for better replicable estimates and effective intervention planning.