Objective approach for fending off the sublingual immunotherapy placebo effect in subjects with pollenosis: double-blinded, placebo-controlled trial

Kralimarkova, Tanya; Popov, Todor A.; Staevska, Maria; Mincheva, Roxana; Lazarova, Cvetelina; Racheva, Rumyana; Mustakov, Tihomir B.; Filipova, Violina; Koleva, M; Bacheva, Kalina; Dimitrov, Vasil

doi:10.1016/j.anai.2014.03.019

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…To our best knowledge, this is the first systematic review and meta‐analysis to comprehensively summarize the relationships between pollen exposure and asthma exacerbation, as assessed through various respiratory outcomes with strict methodological concerns. The existing literature collected in a recent review of the respiratory health burden attributable to short‐term exposure to pollen had already suggested evidence of an association between outdoor pollen concentrations and most of the asthma outcomes we considered, especially in people with pre‐existing respiratory diseases 3–139 . Our overall meta‐analysis, subgroup analysis, and publication bias assessment confirm that a relationship between pollen exposure and asthma exacerbation exists but this require additional research due to its heterogeneity.…”

Section: Discussionsupporting

confidence: 54%

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Annesi‐Maesano

Cecchi

Biagioni

et al. 2023

Allergy

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Limited number of studies have focused on the impact of pollen exposure on asthma. As a part of the EAACI Guidelines on Environment Science, this first systematic review on the relationship of pollen exposure to asthma exacerbations aimed to bridge this knowledge gap in view of implementing recommendations of prevention. We searched electronic iPubMed, Embase, and Web of Science databases using a set of MeSH terms and related synonyms and identified 73 eligible studies that were included for systemic review. When possible, meta‐analyses were conducted. Overall meta‐analysis suggests that outdoor pollen exposure may have an effect on asthma exacerbation, but caution is needed due to the low number of studies and their heterogeneity. The strongest associations were found between asthma attacks, asthma‐related ED admissions or hospitalizations, and an increase in grass pollen concentration in the previous 2‐day overall in children aged less than 18 years of age. Tree pollen may increase asthma‐related ED visits or admissions lagged up to 7‐day overall in individuals younger than 18 years. Rare data show that among subjects under 18 years of age, an exposure to grass pollen lagged up to 3 days may lower lung function. Further research considering effect modifiers of pollen sensitization, hay fever, asthma, air pollution, green spaces, and pre‐existing medications is urgently warranted to better evaluate the impacts of pollen on asthma exacerbation. Preventive measures in relation to pollen exposure should be integrated in asthma control as pollen increase continues due to climate change.

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Section: Discussionsupporting

confidence: 54%

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Annesi‐Maesano

Cecchi

Biagioni

et al. 2023

Allergy

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“…Comparing EBT in patients with EBT measurement reveals asthma improvement in the course of the anti-inflammatory treatment. This has been documented for pharmaceutical products [11, 51, 52], for specific allergen immunotherapy [53] and for an acoustic medical device mobilizing secretions from the lower airways of asthmatics [54]. Similar to serial peak expiratory flow measurement, it follows a day-to-day pattern in line with the control of asthma [55].…”

Section: Asthmamentioning

confidence: 77%

The added value of exhaled breath temperature in respiratory medicine

et al. 2017

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Recognition of the huge economic burden chronic respiratory diseases pose for society motivated fundamental and clinical research leading to insight into the role of airway inflammation in various disease entities and their phenotypes. However, no easy, cheap and patient-friendly methods to assess it have found a place in routine clinical practice. Measurement of exhaled breath temperature (EBT) has been suggested as a non-invasive method to detect inflammatory processes in the airways as a result of increased blood flow within the airway walls. As EBT values are within a narrow range, the thermometers designed for the purpose of assessing it need to be precise and very sensitive. EBT increases linearly over the pediatric age range and seems to be influenced by gender, but not by height and body weight. In non-smoking individuals with no history of respiratory disease EBT has a natural circadian peak about noon and increases with food intake and physical exercise. When interpreting EBT in subjects with alleged airway pathology, the possibilities of tissue destruction (chronic obstructive pulmonary disease, cystic fibrosis) or excessive bronchial obstruction and air trapping (severe asthma) need to be considered, as these conditions drive (force) EBT down. A prominent advantage of the method is to assess EBT when patients are in a steady state of their disease and to use this 'personal best' to monitor them and guide their treatment. Individual devices outfitted with microprocessors and memory have been created, which can be used for personalized monitoring and disease management by telemedicine.

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“…Starting from the characterization of Th2 endotype, experts identified two endotypes: Th2-high and Th2-low (14), which were divided further in several sub-endotypes: IL-5-high, IL-13-high, IgE-high (5). This kind of endotype may also be characterized by several other biomarkers: blood or sputum eosinophilia (15), periostin (16), considered to be characteristic for it. Type 2 immune response underlines atopic asthma and allergic rhinitis (AR) as fundamental for the united airway concept (5).…”

Section: Relationship Between Chemokines and T Lymphocytes In The Conmentioning

confidence: 99%

Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review)

et al. 2020

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Allergic diseases have been classified in the last decades using various theories. The main classes of the newest classification in allergic respiratory diseases focus on the characterization of the endotype (which takes into account biomarkers related to determinant pathophysiological mechanisms) and of the phenotype (based on the description of the disease). Th2, Th1 and Th17 lymphocytes and the type of inflammatory response mediated by them represent the basis for Th2 and non-Th2 endotype classification. In addition, new lymphocytes were also used to characterize allergic diseases: Th9 lymphocytes, Th22 lymphocytes, T follicular helper cells (T FH) lymphocytes and invariant natural killer T (iNKT) lymphocytes. In the last decade, a growing body of evidence focused on chemokines, chemoattractant cytokines, which seems to have an important contribution to the pathogenesis of this pathology. This review presents the interactions between chemokines and Th lymphocytes in the context of Th2/non-Th2 endotype classification of respiratory allergies.

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Objective approach for fending off the sublingual immunotherapy placebo effect in subjects with pollenosis: double-blinded, placebo-controlled trial

Cited by 4 publications

References 29 publications

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

The added value of exhaled breath temperature in respiratory medicine

Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review)

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