An online questionnaire on the subjective response to noise was created to collect national experiences from households during the first COVID-19 wave (from 14 March to 21 June). In this study, different noise sources (general noise, but also noise from neighbors, common areas, facilities, premises, and traffic) and self-declared health effects (stress, lack of concentration, sleep disturbance, anxiety, irritability, or their absence) reported from 582 participants were analyzed (before and during quarantine). A descriptive and statistical analysis between variables was established to observe relational trends for the two periods. The results associated stress and sleep disturbance with most of the noise sources before the pandemic. Sleep disturbance was not significant in confinement, maybe due to habit changes and staying home. Uncertainty linked to the pandemic could explain why stress showed significance during quarantine. Irritability showed an inverse relation with noise sources since their values were greater for declared noise sources and more annoying before the pandemic in all cases. Finally, anxiety showed an association with fewer noise sources, maybe also conditioned by other factors. However, the extreme situation and the uncertainty generated, the presence of cohabitants at home, and building factors (such as acoustic insulation) conditioned the households’ experience.