Object-Oriented Specification of Complex Bio-computing Processes: A Case Study of a Network of Proteolytic Enzymes

Signorini, Jacqueline; Greussay, Patrick

doi:10.1007/978-3-540-27835-1_1

Cited by 1 publication

(2 citation statements)

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“…This calls subsequently for an organ-to-organ study which follows naturally from the simultaneous consideration of biochemical process failures in [4,5] and organ-part failures [6]. In a forthcoming paper, we intend to study the modelling of the regulation of the renin angiotensin system i.e.…”

Section: Discussionmentioning

confidence: 99%

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Silent Killing: an Object-Oriented View of Hypertension and Kidney Failures Part I

Signorini¹,

Greussay²

2007

2007 IEEE 7th International Symposium on BioInformatics and BioEngineering

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As a pathology, the so-called 'silent killer' a.k.a. high blood pressure (HBP) has no noticeable warning symptoms until it is usually too late. Serious heart disease is a major cause of angina and chronic spasm leading to heart attack: kidney diseases and failures are simultaneously causes and consequences of those conditionsl8,111.In this paper, we give an object-oriented specification of kidney failures at their multi functional levels, and we give suggestions for managing the catch-22 cross regulation problem between HBP and dialysis renal functions. As a specification tool, we use UML (Unified Modelling Language) as it offers total industrial compatibility and the safest standard way to describe medical organ failure processes. As a major filtering organ, kidney has been modelized as a target for ultrasonography via case-based specification 111, and as industrial pilot examples for automation and transplantation safety 12,3,41.

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Section: Discussionmentioning

confidence: 99%

“…This paper follows [4,6] in which we gave detailed modelizations of coagulation and liver failures using UML as a specification language [9]. Valuable attempts to design ad-hoc specification languages for biological processes can be found in e.g.…”

Section: Introductionmentioning

confidence: 99%