Object-oriented Model Library of the Cardiovascular System Including Physiological Control Loops

Brunberg, Anja; Maschuw, Jan P.; Autschbach, Rüdiger; Abel, Dirk

doi:10.1007/978-3-642-03895-2_48

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…The Modelica Association maintains a Modelica Standard library, which contains components of various physical domains (mechanical, electrical, hydraulic, thermal and many more). To cater for components to build models of the cardiovascular systems, our open-source Modelica library HumanLib contains components of the mammalian cardiovascular system [9]. Listing 1 demonstrates how the systemic circulation can be modeled in Modelica using components of the HumanLib.…”

Section: Oo Modelingmentioning

confidence: 99%

Benefits of object-oriented models and ModeliChart: modern tools and methods for the interdisciplinary research on smart biomedical technology

Gesenhues

Hein

Ketelhut

et al. 2017

Biomedical Engineering / Biomedizinische Technik

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Computational models of biophysical systems generally constitute an essential component in the realization of smart biomedical technological applications. Typically, the development process of such models is characterized by a great extent of collaboration between different interdisciplinary parties. Furthermore, due to the fact that many underlying mechanisms and the necessary degree of abstraction of biophysical system models are unknown beforehand, the steps of the development process of the application are iteratively repeated when the model is refined. This paper presents some methods and tools to facilitate the development process. First, the principle of object-oriented (OO) modeling is presented and the advantages over classical signal-oriented modeling are emphasized. Second, our self-developed simulation tool ModeliChart is presented. ModeliChart was designed specifically for clinical users and allows independently performing in silico studies in real time including intuitive interaction with the model. Furthermore, ModeliChart is capable of interacting with hardware such as sensors and actuators. Finally, it is presented how optimal control methods in combination with OO models can be used to realize clinically motivated control applications. All methods presented are illustrated on an exemplary clinically oriented use case of the artificial perfusion of the systemic circulation.

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Section: Oo Modelingmentioning

confidence: 99%

Benefits of object-oriented models and ModeliChart: modern tools and methods for the interdisciplinary research on smart biomedical technology

Gesenhues

Hein

Ketelhut

et al. 2017

Biomedical Engineering / Biomedizinische Technik

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“…Furthermore, an ultrasonic flow sensor is placed at the beginning of the Aorta (Q Ao , see Figure 4). Listing 1 contains the complete Modelica model based on components from our library 'HumanLib' (Brunberg et al, 2009). The blood connector used in Listing 1 consists of the potential variable blood pressure (traditionally denoted in mmHg where 1 mmHg = 133.3 Pa, referred to atmospheric pressure) and the flow variable blood flow in ml/sec.…”

Section: Exemplary Application: Identification Of the Systemic Circulmentioning

confidence: 99%

“…Consequently, the adaption, refinement and creation of new models is an integral part within this field. Here, over the years the object-oriented modeling paradigm using Modelica has turned out invaluable for its flexibility for modifications and the concept of acausal formulation of components and has motivated the creation of libraries such as the Physiolibrary (Mateják et al, 2014) or our in-house developed library HumanLib (Brunberg et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Towards Medical Cyber-Physical Systems: Modelica and FMI based Online Parameter Identification of the Cardiovascular System

Gesenhues

Ketelhut

Albin

et al. 2017

Linköping Electronic Conference Proceedings

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This paper presents a concept for online parameter identification intended to be used within cardiovascular research labs and hospitals of the future featuring a data network of medical sensors. It is based on iterative nonlinear optimization using a moving horizon scheme and object-oriented Modelica models. Special FMUs have been developed to interface the optimization module and the sensor hardware. The concept is demonstrated on an exemplary application of identifying the parameters of a model for the systemic circulation. Unlike classical online parameter identification methods, this concept allows for quickly implementing changes of the underlying model.

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“…Since Guyton et al (8) published a circulatory regulation model, knowledge of the cardiovascular system (CVS) has developed dramatically. Today, a broad and profound understanding about the mechanisms in the CVS is available, and many physiological models have been developed (9)(10)(11)(12). These models are used both in numerical simulations and mock circulation loops.…”

mentioning

confidence: 99%

A Hybrid Mock Circulation Loop for a Total Artificial Heart

et al. 2014

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Rotary blood pumps are emerging as a viable technology for total artificial hearts, and the development of physiological control algorithms is accelerated with new evaluation environments. In this article, we present a novel hybrid mock circulation loop (HMCL) designed specifically for evaluation of rotary total artificial hearts (rTAH). The rTAH is operated in the physical domain while all vasculature elements are embedded in the numerical domain, thus combining the strengths of both approaches: fast and easy exchange of the vasculature model together with improved controllability of the pump. Parameters, such as vascular resistance, compliance, and blood volume, can be varied dynamically in silico during operation. A hydraulic-numeric interface creates a real-time feedback loop between the physical and numerical domains. The HMCL uses computer-controlled resistance valves as actuators, thereby reducing the size and number of hydraulic elements. Experimental results demonstrate a stable interaction over a wide operational range and a high degree of flexibility. Therefore, we demonstrate that the newly created design environment can play an integral part in the hydraulic design, control development, and durability testing of rTAHs.

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Object-oriented Model Library of the Cardiovascular System Including Physiological Control Loops

Cited by 3 publications

References 12 publications

Benefits of object-oriented models and ModeliChart: modern tools and methods for the interdisciplinary research on smart biomedical technology

Benefits of object-oriented models and ModeliChart: modern tools and methods for the interdisciplinary research on smart biomedical technology

Towards Medical Cyber-Physical Systems: Modelica and FMI based Online Parameter Identification of the Cardiovascular System

A Hybrid Mock Circulation Loop for a Total Artificial Heart

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