Object–location memory impairment in patients with thermal lesions to the right or left hippocampus

Štěpánková, Kateřina; Fenton, André A.; Pastalkova, Eva; Kalina, Miroslav; Bohbot, Véronique D.

doi:10.1016/j.neuropsychologia.2004.01.002

Cited by 86 publications

(54 citation statements)

References 48 publications

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“…This interpretation is in agreement with reports showing less efficient encoding in elderly adults (Grady et al, 1995;Stebbins et al, 2002), was however not confirmed in a control study on a different group of subjects (Park et al, 1990). Interestingly, object location memory was shown to be dependent on the MTL region (Nunn et al, 1999;Pillon et al, 1999;Stepankova et al, 2004) or more specifically on the parahippocampal gyrus (Maguire et al, 1998b;Owen et al, 1996). Thus another interpretation of this age dependent object location memory deficit may attribute it to the decline in MTL activity.…”

Section: Spatial Memory and Navigationsupporting

confidence: 78%

Spatial Navigation Impairment in Healthy Aging and Alzheimer’s Disease

Vlček¹

2011

The Clinical Spectrum of Alzheimer's Disease -the Charge Toward Comprehensive Diagnostic and Therapeutic Strategies

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Section: Spatial Memory and Navigationsupporting

confidence: 78%

Spatial Navigation Impairment in Healthy Aging and Alzheimer’s Disease

Vlček¹

2011

The Clinical Spectrum of Alzheimer's Disease -the Charge Toward Comprehensive Diagnostic and Therapeutic Strategies

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“…Human lesions restricted to the right hippocampus result in a loss of spatial memory and imply that its spatial role is lateralized to the right hemisphere (Smith andMilner 1981, 1989;Pigott and Milner 1993;Abrahams et al 1997;Nunn et al 1999;Bohbot et al 2000;Astur et al 2002;Stepankova et al 2004). Such a lateralization was supported by neuroimaging studies, which found a preferential processing of words in the left, locations in the right, and pictures in bilateral hippocampus (Schacter and Wagner 1999; Kirchhoff et al 2000;Reber et al 2002).…”

Section: Anterior Mtlmentioning

confidence: 99%

Dissociable contributions within the medial temporal lobe to encoding of object-location associations

Sommer

Rose²,

Gläscher³

et al. 2005

Learn. Mem.

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The crucial role of the medial temporal lobe (MTL) in episodic memory is well established. Although there is little doubt that its anatomical subregions-the hippocampus, peri-, entorhinal and parahippocampal cortex (PHC)-contribute differentially to mnemonic processes, their specific functions in episodic memory are under debate. Data from animal, human lesion, and neuroimaging studies suggest somewhat contradictory perspectives on this functional specialization: a general participation in declarative memory, an exclusive involvement in associative mnemonic processes, and a specific contribution to spatial memory are reported for the hippocampus, adjacent cortices, and the PHC. A functional lateralization in humans dependent on the verbalizability of the material is also discussed herein. To further elucidate the differential contributions of the various MTL subregions to encoding, we employed an object-location association memory paradigm. The memory for each of the studied associations was tested twice: by the object, and by the location serving as retrieval cue. The memory accuracy in response to both cue types was also assessed parametrically. Brain activity during encoding which leads to different degrees of subsequent memory accuracy under the two retrieval conditions was compared. We found the bilateral posterior PHC to participate in encoding of both the object associated with a location and the location associated with an object. In contrast, activity in an area in the left anterior PHC and the right anterior MTL was only correlated with the memory for the location associated with an object.

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“…Associating object and place information into a unitary event representation is believed to be a foundation of episodic memory (Cahusac et al 1989;Gaffan 1994;Davachi 2006). It has been suggested that the hippocampus and its associated regions in the medial temporal lobe (MTL) are essential in this cognitive process, and amnesic patients with damage in the MTL structures exhibit severe deficits in associating object and place information (Smith and Milner 1981;Vargha-Khadem et al 1997;Stepankova et al 2004). Animal models produced by localized lesions in the hippocampus and other MTL structures also support the idea by showing that the lesioned animals are impaired in associating objects and places (Parkinson et al 1988;Gaffan and Parker 1996;Sziklas et al 1998;Bussey et al 2001; Kesner 2003, 2004;Malkova and Mishkin 2003;Lee et al 2005;Bachevalier and Nemanic 2008;Kesner et al 2008;Lee and Solivan 2008).…”

mentioning

confidence: 99%

Perirhinal cortex is necessary for acquiring, but not for retrieving object–place paired association

Jo¹,

Lee²

2010

Learn. Mem.

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Remembering events frequently involves associating objects and their associated locations in space, and it has been implicated that the areas associated with the hippocampus are important in this function. The current study examined the role of the perirhinal cortex in retrieving familiar object-place paired associates, as well as in acquiring novel ones. Rats were required to visit one of two locations of a radial-arm maze and choose one of the objects (from a pair of different toy objects) exclusively associated with a given arm. Excitotoxic lesions of the perirhinal cortex initially impaired the normal retrieval of object-place paired-associative memories that had been learned presurgically, but the animals relearned gradually to the level of controls. In contrast, when required to associate a novel pair of objects with the same locations of the maze, the same lesioned rats were severely impaired with minimal learning, if any, taking place throughout an extensive testing period. However, the lesioned rats were normal in discriminating two different objects presented in a fixed arm in the maze. The results suggest that the perirhinal cortex is indispensable to forming discrete representations for object-place paired associates. Its role, however, may be compensated for by other structures when familiar object-place paired associative memories need to be retrieved.Remembering an event in space often requires associating objects and their locations. Associating object and place information into a unitary event representation is believed to be a foundation of episodic memory (Cahusac et al. 1989;Gaffan 1994;Davachi 2006). It has been suggested that the hippocampus and its associated regions in the medial temporal lobe (MTL) are essential in this cognitive process, and amnesic patients with damage in the MTL structures exhibit severe deficits in associating object and place information (Smith and Milner 1981;Vargha-Khadem et al. 1997;Stepankova et al. 2004). Animal models produced by localized lesions in the hippocampus and other MTL structures also support the idea by showing that the lesioned animals are impaired in associating objects and places (Parkinson et al. 1988;Gaffan and Parker 1996;Sziklas et al. 1998;Bussey et al. 2001; Kesner 2003, 2004;Malkova and Mishkin 2003;Lee et al. 2005;Bachevalier and Nemanic 2008;Kesner et al. 2008;Lee and Solivan 2008). Although the theoretical importance of the MTL structures in object-place association has been well acknowledged, specific contributions of the MTL structures in object-place associative memory are poorly understood. The current study examined the role of the perirhinal cortex, one of the extra hippocampal regions in the MTL, using a behavioral paradigm previously shown to be dependent on the intact hippocampus (Lee and Solivan 2008).The literature suggests that the role of the hippocampus in the object-place paired-associate task is to put together object and place information into a unified and distinct event representation. It has been suggested that spa...

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Object–location memory impairment in patients with thermal lesions to the right or left hippocampus

Cited by 86 publications

References 48 publications

Spatial Navigation Impairment in Healthy Aging and Alzheimer’s Disease

Spatial Navigation Impairment in Healthy Aging and Alzheimer’s Disease

Dissociable contributions within the medial temporal lobe to encoding of object-location associations

Perirhinal cortex is necessary for acquiring, but not for retrieving object–place paired association

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