Object and action naming in Alzheimer's disease and frontotemporal dementia

Cappa, Stefano F.; Binetti, Giuliano; Pezzini, Alessandra; Padovani, Alessandro; Rozzini, Luca; Trabucchi, Marco

doi:10.1212/wnl.50.2.351

Cited by 192 publications

(108 citation statements)

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“…Furthermore, Bak et al [2], Bak and Hodges [3] recently reported that bilateral lesions of frontal areas, as present in motor neuron disease, can also have specific effects on the processing of action verbs. In addition, Cappa et al [10] found most pronounced deficits in fronto-temporal dementia. These data are consistent with the view that the frontal cortices on the left and right both support the action associations of words, thereby facilitating word processing.…”

Section: Comparison Of the Present Results With Earlier Findingsmentioning

confidence: 95%

Word-category specific deficits after lesions in the right hemisphere

2003

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A speeded lexical decision task was used to investigate word-category deficits in patients suffering from lesions in the right hemisphere and in neurological controls without cortical lesion. In all patients from one group (n = 12), the right frontal lobe was affected causing a left-sided hemiparesis. In the second group (n = 6), lesions primarily affected areas in the right inferior temporo-occipital lobes. Patients with motor deficits due to lesions in the spinal cord or in the periphery served as neurological controls (n = 9). Processing of three categories of words was investigated: verbs referring to actions (action verbs (acVs)); nouns with strong visual associations (visually-related nouns (viNs)); and nouns with both strong action and visual associations (bimodal nouns (biNs)). Stimulus categories were matched for word length and normalized lexical frequency. Error scores revealed a significant word category by patient group interaction. Patients with lesions in the right frontal lobe showed most severe deficits in processing action verbs, whereas those with lesions in their right temporo-occipital areas showed most severe deficits in processing visually-related nouns. Neurological controls did not show any differences between word categories. The double dissociation of the processing impairments seen in frontal versus temporo-occipital patients demonstrates that specific word-category deficits can arise from lesions in the right non-dominant hemisphere. An account for these results in terms of distributed neuronal systems representing words is offered.

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Section: Comparison Of the Present Results With Earlier Findingsmentioning

confidence: 95%

Word-category specific deficits after lesions in the right hemisphere

2003

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“…A double dissociation may be postulated between PD patients and those exhibiting selective object-word deficits with relative preservation of action words and action semantics subsequent to posterior atrophy, as observed in Alzheimer's disease [36] and semantic dementia [37,38]. Furthermore, differential activations of frontal/prefrontal regions for verbs, and middle/posterior temporal regions for nouns, have been reported in neuroimaging studies with neurotypical native speakers of English [39,40], German [41], Italian [42], and Japanese [43].…”

Section: Action-language Impairments In Parkinson's Diseasementioning

confidence: 93%

Words in motion: Motor-language coupling in Parkinson’s disease

García¹,

Ibáñez²

2014

Translational Neuroscience

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In recent years, the disruption of non-motor functions in motor disease has emerged as a promising topic for both basic and translational neuroscience. Impairments of movement and cognition were long regarded as separate phenomena [1]. However, a growing body of evidence indicates that neurodegenerative motor disorders also involve high-order cognitive dysfunctions, ranging from working memory, attention, and executive processing deficits [2][3][4], to impairments of language [4][5][6][7][8][9][10] and action knowledge [11]. Further data comes from studies showing that the same genes (e.g., C9orf72) are involved in diseases once perceived as purely motor or purely cognitive, such as motor neuron disease (MND) and frontotemporal dementia, respectively [12].A cognitive domain which seems to be specifically compromised in motor diseases is action language, that is, processing of linguistic stimuli denoting motor actions, including idioms (e.g., cut a rug) and action verbs Words in moTion: moTor-lAnguAge couPling in PArkinson's diseAse Abstract A growing body of evidence indicates that neurodegenerative motor disorders involved high-order cognitive dysfunctions. Crucially, evidence obtained in multiple behavioral, neuroimaging, and electrophysiological studies points to selective impairments of action language -that is, processing of linguistic stimuli denoting motor actions, including idioms (e.g., cut a rug) and action verbs (e.g., clap). Action-verb deficits (with relative preservation of noun processing) have been repeatedly documented in Parkinson's disease (PD). However, research on relevant biomarkers is still scant, and clinical implications of these findings have not yet been formally discussed. Relevant insights may be obtained through the assessment of motor-language coupling (i.e., the behavioral and neural integration of action-verb processing and ongoing motor actions). We propose that motorlanguage coupling deficits, as indexed by a cortical-subcortical network, may constitute an early neurocognitive marker of PD. Specifically, deficits in this domain at the prodromal stage may be detected through the actionsentence compatibility (ACE) paradigm, which induces a contextual coupling of ongoing motor actions and action-verb processing. Our translational proposal is supported and illustrated by recent studies demonstrating the sensitivity of the ACE technique as well as its potential to assist in differential diagnosis and interventionprogram design.

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“…'s specific problems with verb production may stem from damage to part of the left midfrontal gyrus supe-rior to Broca's area, corresponding to Brodmann area 9. Lesions in this region have been linked to verb retrieval deficits in patients with stroke and neurodegenerative diseases [1,8,13], and neuroimaging studies have shown that left prefrontal/premotor cortex is recruited (along with other parts of the brain) more heavily during verb naming than noun naming [36,38]. However, the significance of this association has been controversial.…”

Section: Neuroanatomical Correlates Of Grammatical Processingmentioning

confidence: 99%