Biophysics in Waseda University was started in 1965 as one of the three key research areas that constitute the Physics Department. In the biophysics group, one theoretical lab and two experimental labs are now working on the cutting-edge themes on biophysics, disseminating the ideas and knowledge of biophysics to undergraduate and graduate students from the viewpoint of physics. Keywords Molecular machine • Polymorphism • Allostery • Bioinformatics • Computational biology • Myosin • Actin • Cofilin • On-chip cellomics • Community effect of cells • "Algebraic" system • "Geometric" system What is Waseda University? Waseda University is one of the leading Japanese private research universities located in Shinjuku, the center of Tokyo Metropolis, with about 40,000 undergraduate students and 9,000 postgraduate students. The University was established as Tokyo Senmon Gakko (Tokyo College) on October 21, 1882 by Marquess ShigenobuŌkuma, the 5th Prime Minister of Japan, and was formally renamed to Waseda University in 1902 after the location of the founder's villa in Waseda Village. The University started from three departments, political science and economics, law, and physical science, and is now organized into ten divisions covering 13 undergraduate schools, 24 graduate schools, 21 research institutes, and 9 affiliated institutes at the central campus in Shinjuku, and other branch campuses in Chūō, Nishitōkyō, Tokorozawa, Honjō, and Kitakyūshū. Mission statement of the University was proclaimed by President ShigenobuŌkuma on Waseda University's 30th anniversary in October 1913 as "Waseda University holds as its founding principles the preservation of the independence of scholarship, the promotion of the practical application of