Obez ve sağlıklı çocuklarda leptin ve leptin reseptör gen polimorfizmleri

YARIM, Ayça KANAT; RASULOVA, Khayala; Çatlı, Gönül; Küme, Tuncay; Abacı, Ayhan; KIZILDAĞ, Sefa

doi:10.17826/cumj.977534

Cited by 2 publications

(2 citation statements)

References 58 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, LEPR K109R, K656N, and LEP G2548A polymorphisms were not shown to be associated with obesity according to the results of Yarim et al (2022). However, in the obese group, LEPR Q223R polymorphism has been found to have lower rate of AA genotype, higher rate of genotype and higher rate of G allele, suggesting that this polymorphism could be considered susceptible to obesity.…”

Section: Discussionmentioning

confidence: 87%

GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population

Prodan,

Dzubanovsky,

Kamyshnyi

et al. 2023

Endocrine Regulations

View full text Add to dashboard Cite

Objective. Many conflicting results have been obtained in the study of leptin (LEP) and leptin receptor (LEPR) gene variants that are associated with the obesity and diabetes possibly due to differences in the study populations. The aim of this study was to evaluate changes in the metabolic hormones (leptin, ghrelin, adiponectin, resistin) levels in the blood of obese patients in relation to the GHRL (rs696217), LEP (rs7799039), LEPR (rs1137100, rs1137101, rs1805094) polymorphism in Ukrainian population. Methods. The study involved 53 obesity cases and 48 non-obesity subjects (controls). The GHRL, LEP, and LEPR genes polymorphism (rs696217, rs7799039, rs1137100, rs1137101, rs1805094) was genotyped using a TaqMan real-time polymerase chain reaction method. Blood hormones (leptin, ghrelin, adiponectin, resistin) were determined with commercially available kits using a Multiskan FC analyzer. Results. The study of the effect of genotypes of the GHRL (rs696217), LEP (rs7799039), and LEPR (rs1137100, rs1805094) polymorphisms on the level of metabolic hormones (leptin, ghrelin, adiponectin, resistin) in the blood of obese patients did not show reliably significant results. Thus, the presence of the LEPR genes (rs1137101) polymorphism in the Ukrainian population indicates an increased risk of the metabolic syndrome development regardless of the homozygous or heterozygous genotype (genotypes AA, AG, GG). Conclusions. We established a significant effect of the presence of the A allele and G allele of the LEPR gene polymorphism (rs1137101) on the level of leptin, ghrelin, adiponectin, and resistin in the serum of patients diagnosed with the metabolic syndrome in the Ukrainian population.

show abstract

Section: Discussionmentioning

confidence: 87%

GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population

Prodan,

Dzubanovsky,

Kamyshnyi

et al. 2023

Endocrine Regulations

View full text Add to dashboard Cite

show abstract

“…Obesity has evolved into a prevalent and pressing global health issue, posing medical risks that can lead to several ailments, including cardiovascular disease, elevated blood pressure, diabetes, and some specific cancers [ 84 ]. The link between changes in the LEPR and LEP genes and obesity in individuals is still a topic of ongoing debate.…”

Section: Discussionmentioning

confidence: 99%