Obeticholic Acid Inhibit Mitochondria Dysfunction Via Regulating ERK1/2‐DRP Pathway to Exert Protective Effect on Lipopolysaccharide‐Induced Myocardial Injury
Huijie Miao,
Xiaomeng Tang,
Yun Cui
et al.
Abstract:Farnesoid X receptor (FXR) plays critical regulatory roles in cardiovascular physiology/pathology. However, the role of FXR agonist obeticholic acid (OCA) in sepsis‐associated myocardial injury and underlying mechanisms remain unclear. C57BL/6J mice are treated with OCA before lipopolysaccharide (LPS) administration. The histopathology of the heart and assessment of FXR expression and mitochondria function are performed. To explore the underlying mechanisms, H9c2 cells, and primary cardiomyocytes are pre‐treat… Show more
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