Obestatin/ghrelin ratio: A new activity index in inflammatory bowel diseases

Alexandridis, Efstratios; Zisimopoulos, Athanasios; Liratzopoulos, Nikolaos; Katsos, Ioannis; Manolas, Konstantinos J; Kouklakis, Georgios

doi:10.1002/ibd.20940

Cited by 30 publications

(29 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Plasma obestatin levels were high in anorexia nervosa and epileptic patients compared to normal subjects [19,21,22,[53][54][55][56][57][58][59][60]. Obestatin seem to play a significant role in the pathophysiology of these diseases.…”

Section: Biological Activitiesmentioning

confidence: 82%

Biological effects of obestatin

Asakawa

Cheng

et al. 2011

Endocr

View full text Add to dashboard Cite

Obestatin, a 23-amino-acid peptide, is derived from the preproghrelin precursor. Obestatin was identified in 2005 as a hormone regulating food intake and energy, and having opposite effects to those of ghrelin. However, as studies have progressed, many disputes on the physiological function of obestatin have emerged. The food intake suppressive effects of obestatin have not been replicated in many studies. Nonetheless, many biological roles of obestatin have been revealed, and obestatin is thought to be associated with a variety of biological functions such as feeding, drinking, incretion, memory, and sleep, and with neuropsychiatric manifestations. The biological effects of obestatin will be reviewed in this article.

show abstract

Section: Biological Activitiesmentioning

confidence: 82%

Biological effects of obestatin

Asakawa

Cheng

et al. 2011

Endocr

View full text Add to dashboard Cite

show abstract

“…It is known that the chronic inflammation present in uremic patients undergoing HD plays a key role, since it is a relevant factor for cardiovascular risk, and is correlated with obesity. It has been shown in various studies that obestatin plays a role in pathologic processes, without altering, at least initially, renal function in which the inflammation plays a key role from a physiopathological viewpoint, as in rheumatoid arthritis and in chronic inflammatory intestinal disease [18,19] . Our findings confirm this correlation, evidencing a strong and independent correlation between PCR and obestatin, thus indicating that this hormone may play a physiopathological role in the complex process of inflammation characterizing the uremic patient.…”

Section: Discussionmentioning

confidence: 99%

Obestatin: A New Element for Mineral Metabolism and Inflammation in Patients on Hemodialysis

Lacquaniti¹,

Bolignano²,

Donato³

et al. 2011

Kidney Blood Press Res

View full text Add to dashboard Cite

Background: Obestatin plays a key role in the process of energy balance maintenance with an anorectic effect. The main aim of the study was to evaluate obestatin in uremic patients to determine whether it is correlated with nutritional and inflammatory status. Methods: We studied plasma obestatin in uremic patients (n = 50) undergoing hemodialysis therapy and in healthy subjects. Plasma obestatin was measured using an ELISA kit. Results: Obestatin levels in uremic patients were lower than in healthy subjects (p < 0.0001). Patients with a body mass index (BMI) >23 had lower obestatin levels than those with a BMI <23 (p = 0.001). After multivariate analysis, direct correlations were maintained between obestatin and high-sensitivity C-reactive protein (β = 0.68, p < 0.0001) and total alkaline phosphatases (β = 0.30, p = 0.03), while inverse correlations were found with iron (β = –0.32, p = 0.002) and calcium-phosphorous product (β = –0.40, p = 0.001). Conclusions: Based on the present observational data, obestatin might be implicated in the inflammatory state and the disturbances of calcium/phosphate metabolism of hemodialysis patients. However, further studies are warranted to determine whether this hormone plays a key role in contributing to malnutrition and to the chronic inflammatory process.

show abstract

“…pylori infection [10]. Other reports showed that plasma G/O ratio is related to inflammatory bowel diseases and obesity [12, 18, 19]. …”

Section: Introductionmentioning

confidence: 99%

Plasma ghrelin level and plasma ghrelin/obestatin ratio are related to intestinal metaplasia in elderly patients with functional dyspepsia

Kim

Byun

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

BackgroundWhether plasma ghrelin/obestatin levels are associated with Helicobacter pylori (H. pylori) infection, subtypes of functional dyspepsia (FD), and gastric mucosal histology has not yet been established in elderly patients.ObjectiveThe aim of this study was to determine whether plasma ghrelin and obestatin levels are related to gastric mucosal histology, H. pylori infection, and FD subtypes in elderly patients with FD.MethodsNinety-two patients diagnosed with FD and older than 60 years (median age 69.4; range 60–88) were included. Clinical symptoms investigated included postprandial fullness, epigastric pain, epigastric soreness, nausea, and vomiting. According to the Rome III criteria, patients diagnosed with FD were divided into two subtypes: epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS). Plasma ghrelin and obestatin levels were measured using enzyme immunoassay, and histological examination of gastric mucosa was performed. H. pylori infection was determined by histopathological examination of gastric mucosal biopsy and/or Campylobacter-like organism test.ResultsIn our study, plasma ghrelin levels and plasma ghrelin/obestatin (G/O) ratio were significantly lower in subjects with intestinal metaplasia compared with those without intestinal metaplasia (ghrelin, p = 0.010; G/O ratio, p = 0.012). On the other hand, there were no significant differences in plasma ghrelin and obestatin levels between H. pylori–positive and H. pylori–negative groups. (ghrelin, p = 0.130; obestatin, p = 0.888). Similarly, no significant differences were detected between the EPS and PDS groups (ghrelin, p = 0.238; obestatin, p = 0.710).ConclusionsPatients with intestinal metaplasia, a known precursor of gastric cancer, had significantly less plasma ghrelin levels and G/O ratio than those without intestinal metaplasia.

show abstract

Obestatin/ghrelin ratio: A new activity index in inflammatory bowel diseases

Abstract: Ghrelin and obestatin seem to play a significant role in IBD pathogenesis. Further studies are needed to elucidate the role of these hormones as new biological markers of activity of IBD.

Cited by 30 publications

References 24 publications

Biological effects of obestatin

Biological effects of obestatin

Obestatin: A New Element for Mineral Metabolism and Inflammation in Patients on Hemodialysis

Plasma ghrelin level and plasma ghrelin/obestatin ratio are related to intestinal metaplasia in elderly patients with functional dyspepsia

Contact Info

Product

Resources

About