Obesity without comorbidity may also lead
to non-thyroidal illness syndrome

Keşkek, Şakir Özgür; Kurşun, Özlem; Ortoglu, Gulay; Bankır, Mehmet; Tüzün, Zeynep; Saler, Tayyibe

doi:10.17219/acem/70226

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…Moreover, FT3 level is difficult to interpret because many acute or chronic extra-thyroidal conditions (involving nutritional status and systemic inflammation) can reduce the conversion of T4 to T3, a mechanism known as 'nonthyroidal illness', 'euthyroid sick syndrome' or 'low-T3 syndrome' (51). There are very few data on the incidence of non-thyroidal illness in the obese population but one publication suggested that inflammation may increase non-thyroidal illness in obesity (52). In contrast, FT3 has been described to be higher in obesity than in lean people, this being mainly related to the nutritional status (53).…”

Section: Reasoningmentioning

confidence: 99%

European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

Pasquali

Casanueva

Haluzı́k

et al. 2020

European Journal of Endocrinology

126

156

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Obesity is an emerging condition, with a prevalence of ~20%. Although the simple measurement of BMI is likely a simplistic approach to obesity, BMI is easily calculated, and there are currently no data showing that more sophisticated methods are more useful to guide the endocrine work-up in obesity. An increased BMI leads to a number of hormonal changes. Additionally, concomitant hormonal diseases can be present in obesity and have to be properly diagnosed – which in turn might be more difficult due to alterations caused by body fatness itself. The present European Society of Endocrinology Clinical Guideline on the Endocrine Work-up in Obesity acknowledges the increased prevalence of many endocrine conditions in obesity. It is recommended to test all patients with obesity for thyroid function, given the high prevalence of hypothyroidism in obesity. For hypercortisolism, male hypogonadism and female gonadal dysfunction, hormonal testing is only recommended if case of clinical suspicion of an underlying endocrine disorder. The guideline underlines that weight loss in obesity should be emphasized as key to restoration of hormonal imbalances and that treatment and that the effect of treating endocrine disorders on weight loss is only modest.

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Section: Reasoningmentioning

confidence: 99%

European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

Pasquali

Casanueva

Haluzı́k

et al. 2020

European Journal of Endocrinology

126

156

View full text Add to dashboard Cite

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“…To our current knowledge this is the first paper to report uncoupling excessive weight gain from inflammation. However, there is some supporting data in the literature reporting that few individuals with BMI close to or above 30 can have low CRP levels [40,41,42], thus, obesity does not necessarily cause inflammation in each individual. We hypothesize that different response to the adipose tissue expansion and/or missing inflammatory mediators may be responsible for this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats

Bukosza

Kaucsár

Godó

et al. 2019

IJMS

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Feeding rats with high-fat diet (HFD) with a single streptozotocin (STZ) injection induced obesity, slightly elevated fasting blood glucose and impaired glucose and insulin tolerance, and caused cardiac hypertrophy and mild diastolic dysfunction as published before by Koncsos et al. in 2016. Here we aimed to explore the renal consequences in the same groups of rats. Male Long-Evans rats were fed normal chow (CON; n = 9) or HFD containing 40% lard and were administered STZ at 20 mg/kg (i.p.) at week four (prediabetic rats, PRED, n = 9). At week 21 blood and urine samples were taken and kidney and liver samples were collected for histology, immunohistochemistry and for analysis of gene expression. HFD and STZ increased body weight and visceral adiposity and plasma leptin concentration. Despite hyperleptinemia, plasma C-reactive protein concentration decreased in PRED rats. Immunohistochemistry revealed elevated collagen IV protein expression in the glomeruli, and Lcn2 mRNA expression increased, while Il-1β mRNA expression decreased in both the renal cortex and medulla in PRED vs. CON rats. Kidney histology, urinary protein excretion, plasma creatinine, glomerular Feret diameter, desmin protein expression, and cortical and medullary mRNA expression of TGF-β1, Nrf2, and PPARγ were similar in CON and PRED rats. Reduced AMPKα phosphorylation of the autophagy regulator Akt was the first sign of liver damage, while plasma lipid and liver enzyme concentrations were similar. In conclusion, glomerular collagen deposition and increased lipocalin-2 expression were the early signs of kidney injury, while most biomarkers of inflammation, oxidative stress and fibrosis were negative in the kidneys of obese, prediabetic rats with mild heart and liver injury.

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“…The consequences of obesity are widespread and related to multiple comorbidities, including cardiovascular diseases, type 2 diabetes, dyslipidemia, hypertension, and other chronic disorders 3 . In addition, hypertrophic fat tissue resulting from obesity leads to increasing levels of inflammation with excessive release of pro-inflammatory cytokines, such as interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and C-reactive protein (CRP) 4 5 .…”

Section: Introductionmentioning

confidence: 99%

“…As evidence of inflammation, high levels of erythrocyte sedimentation rate (ESR) and some complete blood count parameters were found 5 . Leukocytes (LE) or white blood cells form part of the immune system and are closely linked to the inflammatory response, and their levels are associated with metabolic and cardiovascular disorders caused by obesity 6 .…”

Section: Introductionmentioning

confidence: 99%

Interval Training with Different Intensities in Overweight/Obese Adolescent Females

et al. 2021

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To compare the effects of 12 weeks of high-intensity interval training (HIIT) versus moderate-intensity interval training (MIIT) on hematological and inflammatory markers in youth females, 38 overweight/obese females (16.4±1.0 yrs.) were randomly assigned to HIIT (2×6–8 repetitions of 30 s at 100–110% maximal aerobic speed (MAS), with 30 s active recovery between repetitions at 50% MAS; n=13), MIIT (2×6–8 repetitions of 30 s at 70–80% MAS, with 30 s active recovery between repetitions at 50% MAS; n=13), and a control group (CG, no intervention; n=12). Body composition, blood pressure, maximal heart rate, hematological and inflammatory markers (C-reactive protein [CRP], and erythrocyte sedimentation rate [ESR]) markers were assessed in all groups before and following the training program. Results revealed a significant (P<0.05) interaction effect for body composition, systolic blood pressure (SBP), MAS, maximal heart rate, and CRP. Within-group analyses for the HIIT and MIIT groups showed significant improvements in body mass (P=0.009 and P=0.025, respectively), BMI Z-score (P=0.011 and P=0.028, respectively), and MAS (P<0.001 and P=0.011, respectively). The HIIT program showed a significant decrease in body fat (P=0.002), waist circumference (P=0.002), maximal heart rate (P=0.003), SBP (P=0.001), and plasma CRP (P=0.004). In both groups, no signiﬁcant changes were observed in ESR and hematological markers after intervention. No variable changed in CG. HIIT was the effective method to manage cardiometabolic health and inflammatory disorders in obese youth.

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Obesity without comorbidity may also lead to non-thyroidal illness syndrome

Abstract: Inflammation, which is strongly associated with adipose tissue, may lead to NTIS in obese patients without any comorbid disease.

Cited by 7 publications

References 15 publications

European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats

Interval Training with Different Intensities in Overweight/Obese Adolescent Females

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