Obesity, Triglycerides, Remnant Cholesterol, and Other Causal Factors in Aortic Valve Stenosis: A Review

Kaltoft, Mikkel; Langsted, Anne; Nordestgaard, Børge G.

doi:10.51789/cmsj.2022.2.e20

Cited by 1 publication

(1 citation statement)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the difference in participants' characteristics may contribute to the difference in results between the two studies. Taken together, previous studies examining the relationship between AVC and obesity indices have been heterogenic with regard to demographics or study design 45) , which may lead to the conflicting results. In our study of the population-based individuals with less advanced CVD risk factors (e.g., low BMI), no association was found between obesity indices and AVC.…”

Section: Discussionmentioning

confidence: 99%

Association of Anthropometric and CT-Based Obesity Indices with Subclinical Atherosclerosis

Higo

Hisamatsu

Nakagawa

et al. 2024

JAT

View full text Add to dashboard Cite

Aim: Few studies have compared the strength in the associations of anthropometric and computed tomography (CT)-based obesity indices with coronary artery calcification (CAC), aortic artery calcification (AoAC), and aortic valve calcification (AVC). Methods: We assessed cross-sectcional associations of anthropometric and CT-based obesity indices with CAC, AoAC, and AVC. Anthropometric measures included body mass index (BMI), waist circumference, hip ircumference, waist-to-hip circumference ratio, and waist-to-height ratio in 931 men (mean age, 63.7 years) from a population-based cohort. CT images at the L4/5 level were obtained to calculate the areas of abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), total adipose tissue (TAT), VAT-to-SAT ratio (VSR), and VAT-to-TAT ratio (VTR). CAC, AoAC, and AVC were quantified using the Agatston score based on CT scanning. Results: CAC, AVC, and AoAC were present in 348 (62.6%), 173 (18.6%), and 769 (82.6%) participants, respectively. In multivariable models adjusting for age, lifestyle factors, and CT types (electron beam CT and multidetector row CT), anthropometric and CT-based obesity indices were positively associated with CAC ( p ＜0.01). Conversely, VAT-to-SAT ratio and VAT-to-TAT ratio were positively associated with AoAC ( p ＜0.01). Any obesity indices were not associated with AVC. Conclusions: The strength of the associations of obesity indices with subclinical atherosclerosis varied according to the anatomically distinct atherosclerotic lesions, among men.

show abstract

Section: Discussionmentioning

confidence: 99%