Obesity risk is associated with brain glucose uptake and insulin resistance

Abstract

Objective: To investigate whether alterations in brain glucose uptake (BGU), insulin action in the brain-liver axis, and whole-body insulin sensitivity occur in young adults in pre-obese state. Methods: Healthy males with either high (HR, n = 19) or low risk (LR, n = 22) for developing obesity were studied with [18F]fluoro-D-glucose ([18F]FDG) - positron emission tomography (PET) during hyperinsulinemic-euglycemic clamp. Obesity risk was assessed according to BMI, physical activity and parental overweight/obesity and type 2 diabetes. Brain, skeletal muscle, brown adipose tissue (BAT), visceral (VAT) and abdominal and femoral subcutaneous adipose tissue (SAT) glucose uptake (GU) rates were measured. Endogenous glucose production (EGP) was calculated by subtracting the exogenous glucose infusion rate from the rate of disappearance of [18F]FDG. BGU were analyzed using statistical parametric mapping (SPM), and peripheral tissue activity was determined using Carimas Software imaging processing platform. Results: BGU was higher in the HR versus LR group, and correlated inversely with whole-body insulin sensitivity (M value) in the HR but not in the LR group. Insulin-suppressed EGP did not differ between the groups, but correlated positively with BGU in the whole population and the correlation was driven by the HR group. Skeletal muscle, BAT, VAT, abdominal and femoral SAT GU were lower in the HR as compared to the LR group. Muscle GU correlated negatively with BGU in the HR but not in the LR group. Conclusion: Increased BGU, alterations in insulin action in the brain-liver axis and decreased whole-body insulin sensitivity occur early in pre-obese state.

Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer’s disease

“…Following dietary intervention, we measured central morphometric parameters established for diet-induced obesity. Similar to prior work (43)(44)(45), HFHC-fed 5xFAD mice exhibited increased body weight gain, gonadal fat and liver weight when compared to CD group (Fig. 1A-C).…”

Profiling and Cellular Analyses of Obesity-Related circRNAs in Neurons and Glia under Obesity-like In Vitro Conditions

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Near-Infrared Spectroscopy: A Free-Living Neuroscience Tool to Better Understand Diabetes and Obesity

“…Moreover, the alteration in brain glucose metabolism was demonstrated in studies employing brain [ 18 F]FDG-PET. Brain glucose hypermetabolism (during conditions of insulin clamp [ 53 ]) appears as an early trait that characterizes subjects with obesity [ 54 ] and subjects at an increased risk of obesity [ 55 ] or prediabetes [ 56 ]. However, diabetes is also associated with whole brain glucose hypometabolism in multiple brain regions [ 57 ].…”