Obesity is a chronic metabolic disease characterized by an excessive adipose tissue accumulation. 1 It is considered a global epidemic and a major public health problem, 2 since this disease can lead to nutritional, metabolic, hormonal, and cardiovascular changes, increasing the population's morbidity and mortality, and reducing life expectancy. [3][4][5] The literature reports that the cause of main obesity, currently, is the inadequate dietary habits, with increased carbohydrate and/or fat consumption. 6,7 However, some individuals seem to present resistance to the development of obesity. Within this context, experiments using animals fed with a high-fat diet try to understand the pathophysiological susceptibility of obesity-resistant individuals to cardiometabolic diseases. [8][9][10]