Obesity-Related Glomerulopathy

Shen, Wenwen; Chen, Hui-mei; Chen, Hao; Xu, Fuqing; Leishi, LI; Liu, Fei

doi:10.2215/cjn.01370210

Cited by 84 publications

(49 citation statements)

References 26 publications

(27 reference statements)

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“…6, HFD-fed mice exhibited elevated levels of ALB (Fig. 6A), which has been consistently observed in obesity-related kidney disease (Shen et al, 2010), and Cr (Fig. 6B) as well as an increased kidney/body weight ratio (Fig.…”

Section: Resultssupporting

confidence: 62%

Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Fang

Deng

Wang

et al. 2015

J Pharmacol Exp Ther

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The prevalence of obesity has increased dramatically worldwide leading to increases in obesity-related complications, such as obesity-related glomerulopathy (ORG). Obesity is a state of chronic, low-grade inflammation, and increased inflammation in the adipose and kidney tissues has been shown to promote the progression of renal damage in obesity. Current therapeutic options for ORG are fairly limited and, as a result, we are seeing increased rates of progression to end-stage renal disease. Chalcones are a class of naturally occurring compounds with various pharmacological properties. 1-(3,4-Dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one (L2H17) is a chalcone that we have previously synthesized and found capable of inhibiting the lipopolysaccharide-induced inflammatory response in macrophages. In this study, we investigated L2H17's effect on obesityinduced renal injury using palmitic acid-induced mouse peritoneal macrophages and high fat diet-fed mice. Our results indicate that L2H17 protects against renal injury through the inhibition of the mitogen-activated protein kinase/ nuclear factor kB pathways significantly by decreasing the expression of proinflammatory cytokines and cell adhesion molecules and improving kidney histology and pathology. These findings lead us to believe that L2H17, as an antiinflammatory agent, can be a potential therapeutic option in treating ORG.

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Section: Resultssupporting

confidence: 62%

Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Fang

Deng

Wang

et al. 2015

J Pharmacol Exp Ther

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“…16 Successful weight loss in patients with obesity-related kidney disease was associated with a reduction in glomerular hyperfiltration and albuminuria. 17,18 In our study, obesity was a predictor of future CKD up to 30 years before diagnosis. However, this effect was attenuated at time points closer to CKD diagnosis.…”

Section: Potential Mechanismssupporting

confidence: 46%

“…73 (10) 72 (11) 79 (10) 80 (10) 80 (10) 81 (9) 79 (9) 82 (11) LDL cholesterol (mg/dl) 116 (35) 113 (37) 135 (35) 135 (36) 136 (34) 136 (36) 129 (34) 131 (37) HDL cholesterol (mg/dl) 54 (17) 51 (16) 51 (15) 49 (15) 52 (15) 50 (15) 52 (15) 51 (15) Log triglycerides (mg/dl) ). The majority of participants (52.5%) were diagnosed with CKD between 1990 and 1999, whereas the remaining cases were diagnosed after 2000.…”

Section: Study Sample Characteristicsmentioning

confidence: 99%

Mid-Adulthood Risk Factor Profiles for CKD

McMahon

Preis

Hwang

et al. 2014

Journal of the American Society of Nephrology

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Early identification of CKD risk factors may allow risk factor modification and prevention of CKD progression. We investigated the hypothesis that risk factors are present $30 years before the diagnosis of CKD in a case-control study using data from the Framingham Offspring Study. Patients with incident CKD (eGFR#60 ml/min per 1.73 m 2 ) at examination cycles 6, 7, and 8 were age-and sex-matched 1:2 to patients without CKD at baseline (examination 5). CKD risk factors were measured at each examination cycle. Logistic regression models, adjusted for age, sex, and time period, were constructed to compare risk factor profiles at each time point between cases and controls. During follow-up, 441 new cases of CKD were identified and matched to 882 controls (mean age 69.2 years, 52.4% women). Those who ultimately developed CKD were more likely to have hypertension (odds ratio [OR], 1.76; 95% confidence interval [CI], 1.23 to 2.51), obesity (OR, 1.71; 95% CI, 1.14 to 2.59), and higher triglyceride levels (OR, 1.43; 95% CI, 1.12 to 1.83) 30 years before CKD diagnosis, and were more likely to have hypertension (OR, 1.38; 95% CI, 1.07 to 1.79), higher triglyceride levels (OR, 1.35; 95% CI, 1.11 to 1.64), lower HDL c (OR, 0.89; 95% CI, 0.81 to 0.97), and diabetes (OR, 2.90; 95% CI, 1.59 to 5.29) 20 years before CKD diagnosis. These findings demonstrate that risk factors for CKD are identifiable $30 years before diagnosis and suggest the importance of early risk factor identification in patients at risk for CKD.

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“…However, it is important to underline that the association between high BMI and CKD has been debated. Indeed, while results of some studies [8,21,22,23,24,25,26,27,28] are in keeping with those of the present one, BMI was not responsible for progression of CKD in diabetic patients [7] and no difference was observed in the rate of annual progression of estimated GFR comparing normal, overweight, and obese nondiabetic patients with stage 3 CKD [29]. …”

Section: Discussionsupporting

confidence: 85%

Impact of BMI on Cardiovascular Events, Renal Function, and Coronary Artery Calcification

Russo

Morrone²,

Errichiello³

et al. 2014

Blood Purif

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Background/Aims: High BMI increases the risk of cardiovascular events (CVEs) in the general population. Conflicting results have been reported on the role of BMI on CVEs and on decline of renal function in patients with chronic kidney disease not on dialysis (CKD). This study evaluates the impact of BMI on CVEs, dialysis initiation, and coronary artery calcification (CAC) in CKD patients. Methods: CKD patients were divided in normal-BMI and high-BMI patients. CVEs, initiation of dialysis, and extent and progression of CAC were assessed. Univariate and multivariable analysis were performed (adjustment variables: age, diabetes, hypertension, gender, CKD stage, serum concentration of hemoglobin, parathyroid hormone, calcium, phosphorus, albumin, C-reactive protein, LDL-cholesterol, total calcium score, 24-hour proteinuria). Patients were followed to the first event (CVE, dialysis) or for 2 years. Results: 471 patients were evaluated. A CVE occurred in 13.5 and 21.3% (p < 0.05) of normal-BMI and high-BMI patients, respectively. High BMI did not increase the risk for CVEs in univariate (HR: 1.86; 95% CI: 0.97-3.54; p = 0.06) or multivariable analysis (HR: 1.36; 95% CI: 0.57-3.14; p = 0.50). High BMI did not increase the risk for initiation of dialysis in univariate (HR: 0.96; 95% CI: 0.58-1.60; p = 0.9) or multivariable analysis (HR: 1.77; 95% CI: 0.82-3.81; p = 0.14). Adding the interaction term (between BMI and glomerular filtration rate) to other variables, the risk of dialysis initiation significantly increased (HR: 3.06; 95% CI: 1.31-7.18; p = 0.01) in high-BMI patients. High BMI was not a predictor of CAC extent or progression. Conclusions: High BMI was not a predictor of CVEs. High BMI increased the risk for dialysis initiation, but high BMI was not associated to CAC extent and progression. The presence of confounders may underestimate the impact of high BMI on dialysis initiation.

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Obesity-Related Glomerulopathy

Cited by 84 publications

References 26 publications

Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Mid-Adulthood Risk Factor Profiles for CKD

Impact of BMI on Cardiovascular Events, Renal Function, and Coronary Artery Calcification

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