Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease

Limpitikul, Worawan B.; Das, Saumya

doi:10.3390/jcdd10080323

Cited by 2 publications

(1 citation statement)

References 128 publications

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“…Fatty Infiltration: Fatty infiltration in the atrial myocardium is linked to obesity and results in structural and electrical changes. Losing weight can stop or reverse this process, which would help the structure and function of the atrial tissue return to normal [78].…”

Section: Cardiac Remodelingmentioning

confidence: 99%

Atrial Fibrillation and Lifestyle Modification: Charting New Courses for Cardiovascular Health

Fahimi,

Beikmohammadi,

Rostami

2024

Preprint

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Atrial fibrillation (AF), a complex cardiac arrhythmia, necessitates a shift in management paradigms, emphasizing an integrative approach that incorporates lifestyle modifications. Investigations into the role of interleukins and inflammatory mediators are underway, exploring their potential as diagnostic markers and predictors of cardiovascular events in AF. Despite the identification of biomarkers related to cardiac remodeling, their predictive ability for post-cardioversion outcomes remains controversial. Computational models are being developed to understand proarrhythmic contributions and identify anti-AF targets. Addressing the rising global incidence of AF, linked to stroke and heart failure, presents a critical health challenge. As risk factors like obesity prevail, AF becomes a pervasive public health concern, expected to double in prevalence over the next 50 years. The impact on mortality and morbidity, especially through hospitalizations, underscores the need for early detection and effective clinical management. Identifying individuals at increased AF risk becomes crucial for screening and prevention strategies. Lifestyle modifications, including weight management and physical activity, emerge as influential factors in AF management, offering the potential to alleviate symptoms and modify disease progression. The paper concludes by emphasizing the need for safer antiarrhythmic therapies based on AF mechanisms, promising improvement in global AF management. The multifaceted nature of AF etiology requires a broader perspective beyond traditional medical interventions, acknowledging the importance of integrated care to address this significant public health challenge.

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Section: Cardiac Remodelingmentioning

confidence: 99%

Atrial Fibrillation and Lifestyle Modification: Charting New Courses for Cardiovascular Health

Fahimi,

Beikmohammadi,

Rostami

2024

Preprint

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Association between Statin use and the risk of atrial fibrillation in community-dwelling older people in Shanghai, China：a propensity score-matched study

Deng,

Sheng,

Zhang

2024

Preprint

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Objective: Whether statins prevent atrial fibrillation remains unclear. In particular, the data on the elderly are limited. Thus we investigated the association between statin use and the risk of atrial fibrillation (AF) in community-dwelling older people in Shanghai ,China. Methods: This registry-based cohort study was conducted in one community in Shanghai. Participants without history of AF were enrolled in this study, then new-onset of AF was recorded and evaluated in the followed three years. Poisson generalized linear models were conducted to examine the association between statin therapy and the incidence of AF. All analysis were performed with both conventional adjustment and propensity score matching methods. Univariate and multivariate regression analysis were performed to evaluate the risk factor of AF in community-dwelling older people Results: In the cohort of 5675 participants (43.5% men; median age, 68.0 years), 456 (8.0%) were treated with stains. Two propensity score-matched cohorts of 453 participants (with or without statin treatment) were analyzed, in respectively. Statin use did not reduce the proportion of atrial fibrillation incidence, with hazard ratios (HRs) and 95% confidence intervals (CIs) of 0.982(0.948 to 1.018) (p＞0.05) in the unmatched cohort and 0.833 (0.459 to 1.512) (p＞0.05) in the matched cohort. The result of multivariate regression analysis showed that age, systolic blood pressure (SBP), BMI, Serum creatinine (Scr), total cholesterol (TC),were the independent risk factors of the new onset of AF. Conclusion: Older age, SBP, BMI, Scr, TC, were independent predictors of AF onset. However, statin use was not associated with a decreased risk of atrial fibrillation incidence of AF in the elderly.

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Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease

Cited by 2 publications

References 128 publications

Atrial Fibrillation and Lifestyle Modification: Charting New Courses for Cardiovascular Health

Atrial Fibrillation and Lifestyle Modification: Charting New Courses for Cardiovascular Health

Association between Statin use and the risk of atrial fibrillation in community-dwelling older people in Shanghai, China：a propensity score-matched study

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