Obesity, Physical Inactivity, and Colonic Diverticular Disease Requiring Hospitalization in Women: A Prospective Cohort Study

Hjern, Fredrik; Wolk, Alicja; Håkansson, Niclas

doi:10.1038/ajg.2011.352

Cited by 111 publications

(96 citation statements)

References 26 publications

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“…[21][22][23] Therefore, the aim in IS patients is to avoid diverticulitis. Smoking and obesity are known to increase the incidence of diverticulitis and complicated diverticulitis [24][25][26][27] ; in contrast physical activity prevents diverticulitis and reduces the risk of complicated diverticulitis. 28,29 The effects of nutrition habits on diverticulitis are controversial.…”

Section: Discussionmentioning

confidence: 99%

Diverticulitis in immunosuppressed patients: A fatal outcome requiring a new approach?

Brandl

Kratzer

Kafka-Ritsch

et al. 2016

cjs

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Section: Discussionmentioning

confidence: 99%

Diverticulitis in immunosuppressed patients: A fatal outcome requiring a new approach?

Brandl

Kratzer

Kafka-Ritsch

et al. 2016

cjs

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“…Similarly, Song et al [13] found no relationship between BMI and asymptomatic diverticulosis found at colonoscopy. A prospective cohort study of Swedish women also found that physical inactivity increased the risk of diverticular disease requiring hospitalization [52]. …”

Section: Obesitymentioning

confidence: 99%

Lifestyle Factors and the Course of Diverticular Disease

Strate¹

2012

Dig Dis

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The dramatic increase in the prevalence of diverticular disease after industrialization has led to the belief that diet and lifestyle factors play a significant role in its pathogenesis. Dietary fiber deficiency has received the most attention, although data are limited and conflicting. Two recent cross-sectional studies found no association between fiber intake and diverticulosis, and one found a positive association. However, fiber may improve symptoms associated with uncomplicated diverticulosis and decrease the risk of diverticulitis. Red meat intake may also increase the risk of diverticular symptoms and complications. Contrary to a long-standing belief, a large prospective study found that nuts and corn did not increase the risk of diverticulitis or diverticular bleeding. A number of case-control and prospective studies have found positive associations between obesity and diverticular complications. Central obesity may be particularly important. Vigorous physical activity appears to reduce the risk of diverticulitis and diverticular bleeding. Findings regarding smoking and diverticular complications have been inconsistent, but suggest that smokers are at increased risk for complications, particularly perforation. Alcohol may increase the risk of asymptomatic diverticulosis and diverticulitis. Research is needed to define the role of lifestyle modification in the primary and secondary prevention of diverticulosis and its complications.

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“…Overweight appears to be a risk, in particular for complicated diverticular disease [22], whereas the relationship with physical exercise is not so clear, even if exercise tends to be seen to have more of a favorable prognosis (table 4) [23,24,25]. …”

Section: Influencing Factorsmentioning

confidence: 99%

Diverticular Disease: Guidelines of the German Society for Gastroenterology, Digestive and Metabolic Diseases and the German Society for General and Visceral Surgery

Kruis

Germer²,

Leifeld³

et al. 2014

Digestion

127

117

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Background: Diverticular disease is one of the most common disorders of the gastrointestinal tract. 28-45% of the population develop colonic diverticula, while about 25% suffer symptoms and about 5% complications. Aim: To create formal guidelines for diagnosis and management. Methods: Six working groups with 44 participants analyzed key questions in subject areas assigned to them. Following a systematic literature search, 451 publications were included. Consensus was obtained by agreement within the working groups, two Delphi processes and a guideline conference. Results: Targeted management of diverticular disease requires a classificatory diagnosis. A new classification was created. In addition to the clinical examination, intestinal ultrasound or computed tomography is the determining factor. Interval colonoscopy is recommended to exclude comorbidities. A low-fiber diet, obesity, lack of exercise, smoking and immunosuppression have an adverse impact on diverticulosis. This can lead to diverticulitis. Antibiotics are no longer recommended in uncomplicated diverticulitis if no risk factors such as immunosuppression are present. If close monitoring is ensured, uncomplicated diverticulitis can be treated on an outpatient basis. Complicated diverticulitis should be treated in hospital, involving broad-spectrum antibiotic therapy, where necessary abscess drainage, and surgery, if possible laparoscopically. In the case of chronic relapsing diverticulitis, the risk of perforation decreases with each episode, so that surgery is no longer recommended after the second episode but only following individual assessment. Conclusions: New findings on diverticular disease call into question the overuse of antibiotics and excessive indications for surgery. Targeted treatment requires a precise diagnosis and intensive interdisciplinary cooperation. i 2014 S. Karger AG, Basel

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Obesity, Physical Inactivity, and Colonic Diverticular Disease Requiring Hospitalization in Women: A Prospective Cohort Study

Abstract: Overweight, obesity, and physical inactivity among women increase diverticular disease requiring hospitalization.

Cited by 111 publications

References 26 publications

Diverticulitis in immunosuppressed patients: A fatal outcome requiring a new approach?

Diverticulitis in immunosuppressed patients: A fatal outcome requiring a new approach?

Lifestyle Factors and the Course of Diverticular Disease

Diverticular Disease: Guidelines of the German Society for Gastroenterology, Digestive and Metabolic Diseases and the German Society for General and Visceral Surgery

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