Obesity, Physical Activity, and Their Interaction in Incident Atrial Fibrillation in Postmenopausal Women

Azarbal, Farnaz; Stefanick, Marcia L.; Salmoirago‐Blotcher, Elena; Manson, Jo Ann E.; Chen, Albert; LaMonte, Michael J.; Larson, Joseph C.; Li, Wenjun; Martin, Lisa W.; Nassir, Rami; Garcı́a, Lorena; Assimes, Themistocles L.; Tharp, Katie M.; Hlatky, Mark A.; Pérez, Marco

doi:10.1161/jaha.114.001127

Cited by 96 publications

(91 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A similar interaction was observed in an analysis from the WHI, in which obese women had a lower risk of AF from increased levels of physical activity. 21 Our study has important implications for obese individuals and suggests that obese individuals may potentially benefit by strategies that can improve CRF, provided that CRF is causally associated with AF. There are many plausible mechanisms for this interaction.…”

Section: Discussionmentioning

confidence: 83%

Cardiorespiratory Fitness and Risk of Incident Atrial Fibrillation

Qureshi

Alirhayim

Blaha³

et al. 2015

Circulation

179

View full text Add to dashboard Cite

A trial fibrillation (AF) is the most common sustained cardiac arrhythmia, currently affecting >2 million people in the United States. 1 With an aging population, its prevalence is projected to double over the next 30 years. 2,3 The total health expenditures incurred by patients with AF are almost 5 times those of patients without AF, ranging between $6 and $26 billion.4 AF is also associated with considerable morbidity and mortality. 5 Although the management of AF has received much attention, literature furthering our understanding of AF prevention remains limited. Editorial see p 1821 Clinical Perspective on p 1834Several studies have suggested an association between lifetime physical activity and the development of AF. 6,7 However, these studies used self-reported physical activity as a measure of physical function, which is not a direct measure of underlying physiology. The impact of cardiorespiratory fitness (CRF) on risk of AF has not been examined previously in large, multiracial cohort. In addition, it is not known if this relationship is influenced by incident coronary artery disease or incident left ventricular dysfunction, and the interactions between modifiable risk factors of AF (including obesity, hypertension, diabetes mellitus, smoking, and hyperlipidemia) and CRF and incident AF are also not well established.Background-Poor cardiorespiratory fitness (CRF) is an independent risk factor for cardiovascular morbidity and mortality.However, the relationship between CRF and atrial fibrillation (AF) is less clear. The aim of this analysis was to investigate the association between CRF and incident AF in a large, multiracial cohort that underwent graded exercise treadmill testing. Methods and Results-From 1991 to 2009, a total of 64 561 adults (mean age, 54.5±12.7 years; 46% female; 64% white) without AF underwent exercise treadmill testing at a tertiary care center. Baseline demographic and clinical variables were collected. Incident AF was ascertained by use of International Classification of Diseases, Ninth Revision code 427.31 and confirmed by linkage to medical claim files. Nested, multivariable Cox proportional hazards models were used to estimate the independent association of CRF with incident AF. During a median follow-up of 5.4 years (interquartile range, 3-9 years), 4616 new cases of AF were diagnosed. After adjustment for potential confounders, 1 higher metabolic equivalent achieved during treadmill testing was associated with a 7% lower risk of incident AF (hazard ratio, 0.93; 95% confidence interval, 0.92-0.94; P<0.001). This relationship remained significant after adjustment for incident coronary artery disease (hazard ratio, 0.92; 95% confidence interval, 0.91-0.93; P<0.001). The magnitude of the inverse association between CRF and incident AF was greater among obese compared with nonobese individuals (P for interaction=0.02). Conclusions Methods Study Population and SettingsThe methods of the Henry Ford Exercise Testing (FIT) Project have been published previously. 8 In short, the FIT...

show abstract

Section: Discussionmentioning

confidence: 83%

Cardiorespiratory Fitness and Risk of Incident Atrial Fibrillation

Qureshi

Alirhayim

Blaha³

et al. 2015

Circulation

179

View full text Add to dashboard Cite

show abstract

“…One recent study demonstrated that greater physical activity was associated with lower rates of AF in postmenopausal women [36], but risk factors associated with AF in the general population are still not clear. The vast majority of our subjects were agricultural workers with high levels of physical activity, which may have contributed to the low prevalence of AF in this population.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of atrial fibrillation and its risk factors in rural China: A cross-sectional study

Sun¹,

Guo²,

Wang³

et al. 2015

International Journal of Cardiology

View full text Add to dashboard Cite

“…Due to this connection, the American Diabetes Association (ADA) recommends aerobic exercise of medium intensity such as 150 minutes of walking per week, or 75 minutes of high intensity aerobic exercise per week for patients with type 2 diabetes [22]. Previous studies showed that only 28% of postmenopausal women perform regular physical activity [23,24]. Despite the beneficial effects of physical activity, there are many complications to achieving the predicted improvement in health.…”

mentioning

confidence: 99%

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Babaei

Damirchi

Hoseini

2015

J. Exerc. Nutr, Biochem.

View full text Add to dashboard Cite

Parvin Babaei, Arsalan Damirchi and Rastegar Hoseini. The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats. Vol. 19, No. 3, pp.173-182, 2015 [Purpose] The purpose of this study was to determine the interaction effects of aerobic exercise training and vitamin D supplementation on indices of obesity and plasma lipid profiles in ovariectomized (OVX) rats.[Methods] Forty female Wistar rats were divided into 5 groups: aerobic training (3 days/week for 8 weeks; AT; n = 8), aerobic training and vitamin D supplementation (OVX + AT + Vit D; n = 8), vitamin D supplementation (OVX + Vit D; n = 8), ovariectomized control (OVX + C, n = 8) and SHAM (n = 8). After blood sampling, visceral fat was taken from the abdominal cavity and weighed immediately. Data was statistically analyzed by One-way ANOVA and Repeated measure ANOVA tests with a 0.05 significance level.[Results] Body weight, visceral fat, BMI and food intake decreased significantly in OVX + AT + Vit D (P < 0.001); whereas these variables increased significantly in OVX + C (P < 0.001) and SHAM (P < 0.023) groups. At the end of two-months of follow-up, we observed significant differences in TC, TG, HDL-C, LDL-C, glucose, insulin, and HOMA-IR in all groups.[Conclusion] It seems that aerobic training with vitamin D, due to the involvement of muscle mass and exposure to dynamic pressure on the bones and muscles, increased energy expenditure, stimulated insulin exudation and glucose homeostasis, decreased insulin resistance and improved the lipid profile in ovariectomized rats.

show abstract

Obesity, Physical Activity, and Their Interaction in Incident Atrial Fibrillation in Postmenopausal Women

Cited by 96 publications

References 44 publications

Cardiorespiratory Fitness and Risk of Incident Atrial Fibrillation

Cardiorespiratory Fitness and Risk of Incident Atrial Fibrillation

Prevalence of atrial fibrillation and its risk factors in rural China: A cross-sectional study

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Contact Info

Product

Resources

About