Obesity is not associated with the poor pregnancy outcome following intracytoplasmic sperm injection in women with polycystic ovary syndrome

Akpınar, Funda; Demır, Berfu; Dilbaz, Serdar; Kaplanoğlu, İskender; Dilbaz, Berna

doi:10.5152/jtgga.2014.13047

Cited by 15 publications

(13 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to our results, high BMI was associated with a decline in oocyte number either in different infertile populations or in high responders. 17,18,21 In our study, despite lower oocyte yield, no significant effect of BMI was found on oocyte fertilization, embryo implantation and pregnancy outcomes, which is consistent with the previous findings. 18,22 Relatively less but considerable number of mature oocytes in obese high responders is thought to contribute to an acceptable number of good quality embryos in our study.…”

Section: Discussionsupporting

confidence: 92%

“…Two recent retrospective analyses revealed a similar trend. 21,24 Since excess numbers of oocytes was shown to correlate positively with OHSS rates, relatively lower oocyte yield in overweight and especially in obese patients seems to justify the less OHSS incidence. 10 Secondly; despite preventive measures, we still detected 8.3% overall OHSS rate in our dataset.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Body Mass Index on ART Outcomes of High-Responders: Prospective Cohort Study

Pabuçcu¹,

Çağlar²,

Kiseli³

et al. 2017

TJRMS

View full text Add to dashboard Cite

A AB BS S T TR RA AC CT TO Ob bj je ec ct ti iv ve e: : Is to evaluate the impact of body mass index (BMI) levels on pregnancy outcomes in high-responders undergoing assisted reproductive technology (ART). M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Total of 120 high responders was allocated to the study. High response was defined as having high serum AMH levels (>4 ng/ml). Subjects were divided into three groups according to their BMI values; normal weight 57 (BMI 18.5-24.9 kg/m 2 ), overweight 42 (25-29.9 kg/m 2 ) and obese 21 subjects (BMI ≥30 kg/m 2 ) were compared for pregnancy outcomes and Ovarian Hyperstimulation Syndrome (OHSS) rates. Gonadotropin starting dose was fixed to 150 IU/day in antagonist co-treated cycles for all subjects. R Re es su ul lt ts s: : A total of 120 cycles were evaluated. In patients with BMI ≥30 kg/m 2 , the total gonadotropin use was significantly higher (p<0.001) and number of retrieved oocytes was significantly lower (p=0.001) when compared to other groups. In normal weight patients, significantly higher numbers of mature oocytes and 2PN embryos were obtained when compared with other groups (p<0.001). Other parameters including number of good quality embryos available for transfer, implantation, biochemical, clinical pregnancy and OHSS rates were similar between all groups. C Co on nc cl lu us si io on n: : Our results did not reveal a significant effect of BMI on the ART outcomes of high responder infertile women. Although higher BMI was correlated with less number of retrieved oocytes, it did not resulted with a negative impact on pregnancy outcomes. Another interesting finding was the trend to a less OHSS incidence with the increase in BMI of high responder patients.K Ke ey y W Wo or rd ds s: : AMH, BMI, high responder, OHSS, pregnancy Ö ÖZ ZE ET T A Am ma aç ç: : Yardımla üreme teknikleri (YÜT) uygulanan yüksek ovaryen yanıtlı olgularda, farklı beden kitle indeksinin (BKİ), gebelik sonuç-ları üzerine etkisini incelemek. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Farklı BKİ değerlerine sahip toplam 120 yüksek ovaryen yanıtlı olgu çalışmaya dahil edildi. Yüksek yanıt kriteri olarak olgudaki serum AMH değerinin >4 ng/ml olması kabul edildi. BKİ değerlerine göre olgular 3 gruba ayrıldı: normal kilolu 57 olgu (BKİ 18,5-24,9 kg/m 2 ), fazla kilolu 42 olgu (BKİ 25-29,9 kg/m 2 ), obez 21 olgu (BKİ >30 kg/m 2 ), gebelik ve ovaryen hiperstimulasyon sendromu (OHSS) oranları açısından karşılaştırıldı. B Bu ul lg gu ul la ar r: : Obez grupta, hem kullanılan gonadotropin dozu hem de toplanan oosit sayısı, diğer 2 gruba göre anlamlı olarak daha az saptandı (p<0,05). Fertilizasyon, gebelik oranları ve diğer parametreler açısından gruplar arasında farklılık saptanmadı. S So on nu uç ç: : YÜT uygulaması yapılan yüksek yanıtlı olgularda, BKİ değerlerinin, YÜT sonuçlarına belirgin etkisinin olmadığı ortaya konulmuştur. Obez olgularda toplanan oosit sayısının az olmasının yanında, gebelik oranlarında farklılık saptanmamıştır. OHSS oranlarının, BKİ arttıkça bir miktar...

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The Impact of Body Mass Index on ART Outcomes of High-Responders: Prospective Cohort Study

Pabuçcu¹,

Çağlar²,

Kiseli³

et al. 2017

TJRMS

View full text Add to dashboard Cite

show abstract

“…Obesity increases the volume of distribution of drugs, which increases the amount of drug required for the equivalent action at the target organ. 18 Obesity also decreases sex hormone-binding globulin levels, which increases the levels of free oestradiol and testosterone. 19 Fatty tissue converts testosterone into oestriol, which is a much less potent oestrogen than oestradiol.…”

Section: Discussionmentioning

confidence: 99%

The significance of anthropometric and endocrine parameters in ovulation induction with clomiphene citrate in women with polycystic ovary syndrome

Akpınar

Dilbaz

Cırık

et al. 2016

SMJ

Self Cite

View full text Add to dashboard Cite

Objectives:To investigate factors associated with the response to ovarian stimulation in patients with polycystic ovary syndrome.Methods:The records of patients with polycystic ovary syndrome and infertility who underwent ovulation induction with clomiphene citrate were reviwed between January 2011 and December 2014 in Etlik Zübeyde Hanim Women’s Health Training and Research Hospital Ankara, Turkey. The anthropometric and endocrine factors of patients who were resistant to treatment at a dose of 150 mg/day (n=84) were compared with those who responded with growth of at least one graaffian follicle at a dose of 50 mg/day (n=342).Results:Of the parameters examined, body mass index, luteinizing hormone level, and luteinizing hormone/follicle stimulating hormone ratio were significantly higher in the clomiphene citrate-resistant group compared with the responsive group.Conclusion:Reproductive treatment in patients with polycystic ovary syndrome show different outcomes. Significantly higher body mass index, luteinizing hormone level, and luteinizing hormone/follicle stimulating hormone ratio observed in clomiphene citrate resistant group can be a possible explanation for this impedance.

show abstract

“…The need to increase gonadotropin concentrations is also associated with differences in the absorption, distribution, and clearance rate of the administered gonadotropins by the excessive adipose tissue (71). Akpınar et al (77) reported an increase in the total gonadotropin consumption and a decrease in the number of retrieved oocytes with an increased body mass index. However, they found an implantation and clinical pregnancy rate in obese and overweight women, similar to normal weight women following intracytoplasmic sperm injection.…”

Section: Obesity and Assisted Conceptionmentioning

confidence: 99%

Impact of obesity on infertility in women

Dağ

Dilbaz

2015

J Turkish German Gynecol Assoc

Self Cite

200

View full text Add to dashboard Cite

Review 111 IntroductionObesity, which is an important health issue, is a common problem among women of reproductive age. Obesity and overweight involves an abnormal and excessive fat accumulation that negatively affects the health of the body. According to the World Health Organization (WHO), if the body mass index (BMI) equals to or is greater than 25 kg/m 2 , it is considered overweight, whereas if the BMI equals to or is greater than 30 kg/m 2 , it is considered obesity (1). Obesity brings out many problems such as social, psychological, demographic, and health problems. It is related to increased health risks such as diabetes mellitus, hypertension, coronary heart disease, and osteoarthritis and is linked to various malignancies, particularly endometrium, breast, and colon cancers. Obesity also plays a significant role in reproductive disorders, particularly in women. It is associated with anovulation, menstrual disorders, infertility, difficulties in assisted reproduction, miscarriage, and adverse pregnancy outcomes. In obese women, gonadotropin secretion is affected because of the increased peripheral aromatization of androgens to estrogens. The insulin resistance and hyperinsulinemia in obese women leads to hyperandrogenemia. The sex hormone-binding globulin (SHBG), growth hormone (GH), and insulin-like growth factor binding proteins (IGFBP) are decreased and leptin levels are increased. Thus, the neuroregulation of the hypothalamic-pituitary-gonadal (HPG) axis deteriorates (2). These alterations may explain impaired ovulatory function and so reproductive health. Because of lower implantation and pregnancy rates, higher miscarriage rates, and increased maternal and fetal complications during pregnancy, obese women have a lower chance to give birth to a healthy newborn (3)(4)(5)(6). In this review, the effects of obesity on fertility and effective management of infertility in obese and overweight women is summarized. Epidemiology of obesityThe prevalence of obesity is increasing significantly worldwide. The International Obesity Task Force reported that 1,1 billion adults are overweight. They also reported that 312 million of them are obese (7). Approximately 3,4 million adults die each year because of health problems associated with obesity and being overweight. Of these, 44% of the problems are related to diabetes, 23% to ischemic heart disease, and between 7% and 41% to some malignancies associated with overweight and obesity (7). The prevelence of obesity has increased in developed countries because of a change in lifestyle, including reduced physical activity, changes in nutrition style, and an increased calorie intake (8). However, some other factors such as endocrine disorders, hormonal disorders, psychological disorders, and use of some drugs such as steroids and antidepressants may lead to obesity (9). The World Health Organization reported that 60% of women are overweight (≥25 kg/m 2 ) in the United States and most European countries and 30% of these are obese (≥30 kg/m 2 ) and 6% of these are mo...

show abstract

Obesity is not associated with the poor pregnancy outcome following intracytoplasmic sperm injection in women with polycystic ovary syndrome

Abstract: The body mass index did not affect the outcome of in vitro fertilization in women with polycystic ovary syndrome. Additional research is required to better understand the role of stimulation protocols on the cycle outcome.

Cited by 15 publications

References 26 publications

The Impact of Body Mass Index on ART Outcomes of High-Responders: Prospective Cohort Study

The Impact of Body Mass Index on ART Outcomes of High-Responders: Prospective Cohort Study

The significance of anthropometric and endocrine parameters in ovulation induction with clomiphene citrate in women with polycystic ovary syndrome

Impact of obesity on infertility in women

Contact Info

Product

Resources

About