Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study

Lashen, Hany; Fear, Kenneth; Sturdee, David W.

doi:10.1093/humrep/deh277

Cited by 519 publications

(339 citation statements)

References 16 publications

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“…Other issues relating to maternal obesity that were identified in the interviews and that are supported by published evidence relate to a higher incidence of shoulder dystocia, 5,22 longer duration of labour, 20 postoperative maternal morbidities such as wound infections and urinary tract infections, 15,5 length of stay and frequency of contact/level of care required because of coexisting and developing co-morbidities, 15,8 and complications with the infant during delivery and neonatally such as fetal distress, birth trauma, and feeding difficulties. 5,19,16,22 A number of issues raised in the interviews are not supported by published research; this may be because of the reliance of the majority of published studies on quantitative methodology and addressing specific biomedical impacts of maternal obesity, in particular relating to the outcome of pregnancy.…”

Section: Discussionmentioning

confidence: 75%

“…The need for induction of labour and caesarean deliveries when the mother is obese or morbidly obese has been reported by numerous studies. 5,[11][12][13][14][15][16][17][18][19] Vahratian et al 20 discuss the need for more frequent administration of oxytocin to stimulate contractions during labour and a significant increase in emergency caesarean deliveries in the obese mother. Rode et al 21 also address a significant increase in emergency caesarean delivery rates, as well as overall caesarean rates, and elective caesareans.…”

Section: Discussionmentioning

confidence: 99%

“…There are increased risks to the mother throughout the pregnancy (including gestational diabetes, hypertensive disorders, and thromboembolic complications) and to the infant (including macrosomia, shoulder dystocia, late fetal death, and congenital abnormalities), and there are also increased complications during labour and also the need for more frequent induced and operative deliveries. 2,3 Limited UK research has shown that these reported health risks and complications are also relevant to the UK population, [4][5][6] and the 2004 triennial report by the Confidential Enquiries into Maternal and Child Health showed that 35% of all maternal deaths in 2000-2002 were in obese women (body mass index [BMI] ‡ 30 kg/m 2 ); 50% more than in the general population. 7 In addition to the increased health risks associated with obesity in women who become pregnant, there is also a demand for additional care and resource from health service providers.…”

Section: Introductionmentioning

confidence: 99%

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Obesity in pregnancy: a study of the impact of maternal obesity on NHS maternity services

Heslehurst

Lang

Rankin

et al. 2007

BJOG

137

133

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Objective To gain a detailed understanding of healthcare professionals' perceptions of the impact that caring for obese pregnant women has on maternity services.Design Qualitative interview study using purposeful sampling and face-to-face interviews.Setting Sixteen maternity units in NHS Trusts in the North East Government Office Region of England, UK.Sample Thirty-three maternity and obstetric healthcare professionals with personal experience of managing the care of obese pregnant women.Methods Semi-structured interviews with healthcare professionals representing each maternity unit in the region. Transcripts were analysed using systematic content analysis.Main outcome measures Views on the impact maternal obesity has on maternity services, the facilities required to care for obese mothers in pregnancy, and existing services directed towards maternal obesity.Results Five dominant themes relating to service delivery emerged; booking appointments, equipment, care requirements, complications and restrictions, and current and future management of care. Many of the issues identified were associated with managing the care of obese women in pregnancy safely, resources and cost issues to be able to do this, multidisciplinary care requirements because of coexisting morbidities when the mother is obese, and restricted care options and patient choice.Conclusions Healthcare professionals in the North East of England feel that maternal obesity has a major impact on services and resource, on the health of both the mother and child, and on the psychological wellbeing of the mother.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Obesity in pregnancy: a study of the impact of maternal obesity on NHS maternity services

Heslehurst

Lang

Rankin

et al. 2007

BJOG

137

133

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“…RM is one of the most disturbing women's health issues and several medical factors (chromosomal, anatomic, autoimmune, and metabolic disorders) have been reported as possible causes [4][5][6][7][8]. However, after standard investigations, up to 50% of these cases remain unexplained [2,9,10].…”

Section: Introductionmentioning

confidence: 99%

Factor V Leiden and prothrombin G20210A in Portuguese women with recurrent miscarriage: is it worthwhile to investigate?

Serrano

Lima

Lopes

et al. 2011

Arch Gynecol Obstet

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Objective To compare the prevalence of factor V Leiden (FVL) and prothrombin (PT) G20210A mutations in Portuguese women with unexplained recurrent miscarriage (RM) and a control group of parous women. Materials and methods FVL and PT G20210A analysis were carried out in 100 women with three or more consecutive miscarriages and 100 controls with no history of pregnancy losses. Secondary analysis was made regarding gestational age at miscarriage (embryonic and fetal losses). Results Overall, the prevalence of FVL and PT G20210A was similar in women with RM (5 and 3%) compared with controls (5 and 1%) OR 1.36 (CI 95% 0.45-4.08). In RM embryonic subgroup, PT G20210A was observed in 1.3% of women and FVL prevalence (2.6%) was inclusively lesser than that of controls. Both polymorphisms were more prevalent in women with fetal losses than in controls, although statistical significance was not reached due to the small size of the [10 weeks' subgroup. Conclusion These data indicate that neither FVL nor PT G20210A is associated with RM prior to 10 weeks of gestation. Therefore, its screening is not indicated as an initial approach in Portuguese women with embryonic RM and negative personal thromboembolic history.

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“…Human obesity is an important health concern, and many studies concerning assisted reproductive technologies (ART) have shown that obesity is associated with detrimental reproductive outcomes [1][2][3][4][5][6][7]. However, there are few reports on the influence of human obesity on embryonic vitrification.…”

Section: Introductionmentioning

confidence: 99%

Maternal obesity in mice not only affects fresh embryo quality but also aggravates injury due to vitrification

Huang

Yang

et al. 2016

J Assist Reprod Genet

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Purpose The aims of the present study are to identify the mechanism(s) whereby obesity impairs fresh embryos and to clarify the effects of vitrification on lipid droplet content within embryos from maternally obese mice. Methods The diet-induced obesity mouse model was established, and the zygotes were captured and cultured to day 3. The eight-cell embryos were selected and divided into fresh and vitrified groups. The blastocysts derived from fresh embryos were used as a control. The expression profiles of endoplasmic reticulum (ER) stress genes (Atf4, Grp78, and Hsp70) and other genes (MnSOD, p53, Gadd45g, caspase-3, IGF-II, ZO-1, and E-cadherin) on day-3 fresh and postwarming eight-cell embryos from obese and control groups were determined. For day-5 fresh blastocysts and blastocysts previously vitrified on day 3, the expression profiles for all of the above genes were also determined. Results For the fresh group, obesity significantly upregulated Hsp70, p53, IGF-II, and ZO-1 expression in embryos on day 3 and notably upregulated Atf4, MnSOD, Gadd45g, caspase-3, ZO-1, and E-cadherin expression in blastocysts on day 5. For vitrified ones, obesity significantly upregulated Atf4, MnSOD, and Gadd45g expression in embryos on day 3 and notably upregulated Hsp70 expression and downregulated MnSOD in day 5 blastocysts previously vitrified on day 3. Conclusions Obesity impairs fresh embryos and aggravates embryonic vitrification injury at a molecular level.

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Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study

Abstract: Obesity is associated with increased risk of first trimester and recurrent miscarriage.

Cited by 519 publications

References 16 publications

Obesity in pregnancy: a study of the impact of maternal obesity on NHS maternity services

Obesity in pregnancy: a study of the impact of maternal obesity on NHS maternity services

Factor V Leiden and prothrombin G20210A in Portuguese women with recurrent miscarriage: is it worthwhile to investigate?

Maternal obesity in mice not only affects fresh embryo quality but also aggravates injury due to vitrification

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