Obesity is associated with an increased prevalence of penicillin allergy

Abbassi, Sarah; Capitle, Eugenio; Trivedi, Radhika; Wolff, A.

doi:10.1016/j.anai.2020.10.012

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…The data suggest a higher frequency of obesity in patients presenting with suspected antibiotics hypersensitivity than for nonopioid analgesics, as well as an association of confirmed hypersensitivity to antibiotics with obesity. Our data support the recent observation that obesity is more frequent in patients with confirmed drug allergy (total n = 84 with 34 positive DHR, 93% were antibiotics) (17) and penicillin allergy (18). Whether this results from more frequent use of antibiotics and thus the probability of sensitization or whether obese patients present rather after stronger and certain reactions is not known but would explain the data.…”

Section: Discussionsupporting

confidence: 89%

Cofactors of drug hypersensitivity—A monocenter retrospective analysis

et al. 2023

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BackgroundDrug hypersensitivity reactions (DHRs) are major medical problems that influence the treatment of patients by both under- and overdiagnosis. Still, little is known about the role of predisposing or protecting cofactors of DHR.ObjectiveThis study aims to determine drug-specific cofactors in patients with DHR.MethodsRetrospective file chart analysis of inpatients with suspected DHR in our department between 2015 and 2020 was performed. Descriptive statistics and multiple logistic regression were conducted for the estimation and statistical interference.ResultsDHRs were suspected in 393 patients with 678 culprit drugs. In 183 cases, drug hypersensitivities were confirmed, mostly against nonopioid analgesic drugs and antibiotics. Multiple logistic regression analysis identified a positive association of antibiotic hypersensitivity with obesity [odds ratio (OR) 5.75, average marginal effect (AME) +24.4%] and age and a negative association with arterial hypertension, female sex, elevated immunoglobulin E (IgE), and allergic rhinitis. Hypersensitivity to nonopioid analgesics was associated with atopic dermatitis (OR 10.28, AME +28.5%), elevated IgE, and arterial hypertension.ConclusionsDrug-specific cofactors of DHR include obesity for antibiotics and atopic dermatitis for nonopioid analgesics, the knowledge of which may improve the risk calculation for drug provocation tests.

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Section: Discussionsupporting

confidence: 89%

Cofactors of drug hypersensitivity—A monocenter retrospective analysis

et al. 2023

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“…Moreover, both allergies and obesity are strongly influenced by lifestyle determinants, especially the diet. These parallels propose a relation between these two diseases, which in fact has been proven in previous studies on asthma [ 3 ], food [ 4 ], and drug [ 5 , 6 ] allergies. However, despite the evidence, causes of this association are not very well understood yet.…”

Section: Discussionmentioning

confidence: 54%

“…Besides that, obesity has also been known as a major health issue not only related to modulators of the innate but also the adaptive immune response. On that note, previous studies have reported a link between obesity and an increased prevalence of different allergic disorders including asthma [ 3 ], food [ 4 ], and drug allergies [ 5 , 6 ]. While these previous studies have reliably reported an increased prevalence of allergies in overweight and obese people, the causes of this association are not very well understood yet.…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies

et al. 2022

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Background: Alongside metabolic diseases (esp. obesity), allergic disorders are becoming increasingly prevalent. Since both obesity and allergies are highly impacted by environmental determinants, with this study we assessed the potential link between metabolic implications and two distinct types of allergies. Methods: Using cross-sectional data from the German FoCus cohort, n = 385 allergy cases, either hay fever (=type I allergy, n = 183) or contact allergy (=type IV allergy, n = 202) were compared to age- and sex-matched healthy control subjects (1:1 ratio, in total n = 770) regarding their metabolic phenotype, diet, physical activity, sleep, gut microbial composition, and serum metabolite profile using suitable BMI-adjusted models. Results: Obesity and metabolic alterations were found significantly more prevalent in subjects with allergies. In fact, this relation was more pronounced in contact allergy than hay fever. Subsequent BMI-adjusted analysis reveals particular importance of co-occurring hyperlipidaemia for both allergy types. For contact allergy, we revealed a strong association to the dietary intake of poly-unsaturated fatty acids, particularly α-linolenic acid, as well as the enrichment of the corresponding metabolic pathway. For hay fever, there were no major associations to the diet but to a lower physical activity level, shorter duration of sleep, and an altered gut microbial composition. Finally, genetic predisposition for hyperlipidaemia was associated to both contact allergy and hay fever. Conclusions: Reflected by higher allergy prevalence, our findings indicate an impaired immune response in obesity and hyperlipidaemia, which is differentially regulated in type I and type IV allergies by an unfavourable lifestyle constellation and subsequent microbial and metabolic dysfunctions.

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Obesity is associated with an increased prevalence of penicillin allergy

Cited by 2 publications

References 9 publications

Cofactors of drug hypersensitivity—A monocenter retrospective analysis

Cofactors of drug hypersensitivity—A monocenter retrospective analysis

Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies

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