Obesity Is Associated with an Impaired Baseline Repertoire of Anti-Influenza Virus Antibodies

Alhadi, Marwa Abd; Friedman, Lilach M.; Karlsson, Erik A.; Cohen-Lavi, Liel; Burkovitz, Anat; Schultz‐Cherry, Stacey; Noah, Terry L.; Weir, Samuel S.; Shulman, Lester M.; Beck, Melinda A.; Hertz, Tomer

doi:10.1128/spectrum.00010-23

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Cited by 2 publications

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“… 4 Furthermore, a defective IgM to IgG antibody class switching, abundance of non-neutralizing antibodies, and a reduced baseline breadth of anti-influenza virus antibodies have also been reported in obese individuals. 5 …”

Section: Main Textmentioning

confidence: 99%

Obesity negatively impacts maintenance of antibody response to COVID-19 vaccines

Chauvin

Retnakumar

Bayry

2023

Cell Reports Medicine

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Section: Main Textmentioning

confidence: 99%

Obesity negatively impacts maintenance of antibody response to COVID-19 vaccines

Chauvin

Retnakumar

Bayry

2023

Cell Reports Medicine

View full text Add to dashboard Cite

Hemagglutination Inhibition Antibody Titers as Mediators of Influenza Vaccine Efficacy Against Symptomatic Influenza A(H1N1), A(H3N2), and B/Victoria Virus Infections

Lim,

Feng,

Wong

et al. 2024

The Journal of Infectious Diseases

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Background The hemagglutination inhibition antibody (HAI) titer mediates only a part of vaccine-induced protection against influenza virus infections. Using causal mediation analysis, we quantified the proportion of vaccine efficacy mediated by post-vaccination HAI titers. Methods Causal mediation analyses were conducted using data collected for a randomized, active-comparator controlled, phase 3 trial of a candidate inactivated, split-virion seasonal quadrivalent influenza vaccine (QIV) in children aged 3 to 8 years conducted from October 2010 to December 2011 in eight countries. Vaccine efficacy was estimated with a weighted Cox proportional hazards regression model. Estimates were decomposed into the direct and indirect effects mediated by post-vaccination HAI titers. Results The proportions of vaccine efficacy mediated by post-vaccination HAI titers were estimated to be 22% (95% CI: 18%, 47%) for influenza A(H1N1), 20% (95% CI: 16%, 39%) for influenza A(H3N2), and 37% (95% CI: 26%, 85%) for influenza B/Victoria. Conclusions HAI titers partially mediate influenza vaccine efficacy against influenza A(H1N1), A(H3N2), and B/Victoria. Our estimates were lower than previous studies, possibly reflecting expected heterogeneity in antigenic similarity between vaccine and circulating viruses across seasons. Data from more influenza seasons are needed to understand better the mediating effects of HAI titers on vaccine efficacy.

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Obesity Is Associated with an Impaired Baseline Repertoire of Anti-Influenza Virus Antibodies

Cited by 2 publications

References 49 publications

Obesity negatively impacts maintenance of antibody response to COVID-19 vaccines

Obesity negatively impacts maintenance of antibody response to COVID-19 vaccines

Hemagglutination Inhibition Antibody Titers as Mediators of Influenza Vaccine Efficacy Against Symptomatic Influenza A(H1N1), A(H3N2), and B/Victoria Virus Infections

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