Obesity is associated with a higher Torque Teno viral load compared to leanness

Herz, Carsten Thilo; Kulterer, Oana C.; Kulifaj, Dorian; Gelas, Fanny; Franzke, B.; Haupenthal, Frederik; Prager, Gerhard; Langer, Felix B.; Marculescu, Rodrig; Haug, Alexander; Kiefer, Florian W.; Bond, Gregor

doi:10.3389/fendo.2022.962090

Cited by 5 publications

(4 citation statements)

References 45 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This might be a result of the fact that, besides truly TTV-negative participants (with no previous TTV infection), there may also be participants with a negative PCR due to a strong suppression of TTV. No association between BMI and TTV load was found, which is in contrast to a cohort study described by Herz et al, where obesity was associated with a higher TTV load [59]. This discrepancy can possibly be explained by the fact that Herz et al compared lean participants (BMI 22.3 ± 2.0 kg/m 2 ) with obese participants (BMI 40.4 ± 6.6 kg/m 2 ), while the participants described in the current article had a rather normal BMI (median BMI 26.1 kg/m 2 with a 75th percentile of 29.4 kg/m 2 ).…”

Section: Discussioncontrasting

confidence: 99%

High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients

Jonker,

Doorenbos,

Kremer

et al. 2024

Viruses

View full text Add to dashboard Cite

Torque teno virus (TTV) is emerging as a potential marker for monitoring immune status. In transplant recipients who are immunosuppressed, higher TTV DNA loads are observed than in healthy individuals. TTV load measurement may aid in optimizing immunosuppressive medication dosing in solid organ transplant recipients. Additionally, there is a growing interest in the role of HDL particles in immune function; therefore, assessment of both HDL concentrations and TTV load may be of interest in transplant recipients. The objective of this study was to analyze TTV loads and HDL parameters in serum samples collected at least one year post-transplantation from 656 stable outpatient kidney transplant recipients (KTRs), enrolled in the TransplantLines Food and Nutrition Cohort (Groningen, the Netherlands). Plasma HDL particles and subfractions were measured using nuclear magnetic resonance spectroscopy. Serum TTV load was measured using a quantitative real-time polymerase chain reaction. Associations between HDL parameters and TTV load were examined using univariable and multivariable linear regression. The median age was 54.6 [IQR: 44.6 to 63.1] years, 43.3% were female, the mean eGFR was 52.5 (±20.6) mL/min/1.73 m2 and the median allograft vintage was 5.4 [IQR: 2.0 to 12.0] years. A total of 539 participants (82.2%) had a detectable TTV load with a mean TTV load of 3.04 (±1.53) log10 copies/mL, the mean total HDL particle concentration was 19.7 (±3.4) μmol/L, and the mean HDL size was 9.1 (±0.5) nm. The univariable linear regression revealed a negative association between total HDL particle concentration and TTV load (st.β = −0.17, 95% CI st.β: −0.26 to −0.09, p < 0.001). An effect modification of smoking behavior influencing the association between HDL particle concentration and TTV load was observed (Pinteraction = 0.024). After adjustment for age, sex, alcohol intake, hemoglobin, eGFR, donor age, allograft vintage and the use of calcineurin inhibitors, the negative association between HDL particle concentration and TTV load remained statistically significant in the non-smoking population (st.β = −0.14, 95% CI st.β: −0.23 to −0.04, p = 0.006). Furthermore, an association between small HDL particle concentration and TTV load was found (st.β = −0.12, 95% CI st.β: −0.22 to −0.02, p = 0.017). Higher HDL particle concentrations were associated with a lower TTV load in kidney transplant recipients, potentially indicative of a higher immune function. Interventional studies are needed to provide causal evidence on the effects of HDL on the immune system.

show abstract

Section: Discussioncontrasting

confidence: 99%

High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients

Jonker,

Doorenbos,

Kremer

et al. 2024

Viruses

View full text Add to dashboard Cite

show abstract

“…For the BMI, obesity was associated with a higher TTV DNA load than lean patients (2.39 log 10 copies/ml [1.69–3.33] vs. 1.88 log 10 copies/ml [1.08–2.43], P = 0.027) in the Herz et al. 34 study. This result is confirmed by our study and may reflect a compromised immune function in this particular population.…”

Section: Discussionmentioning

confidence: 83%

Evaluation of Torque Teno Virus DNA Load as a Predictive Biomarker in Kidney Transplant Recipients Converted from Calcineurin Inhibitors to Belatacept

Cabezas,

Truffot,

Germi

et al. 2024

Kidney International Reports

View full text Add to dashboard Cite

“…Furthermore, we revealed a significant association between higher TTV loads and age, which has been demonstrated before for healthy adults ( 36 , 37 ) as well as for KTRs ( 20 , 34 ), and may be explained by immunosenescence and the accompanying higher susceptibility to pathogens in the elderly population ( 38 ). Moreover, a higher BMI was linked to elevated TTV loads, suggesting impaired immune functionality in obese patients compared with non-obese individuals ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Dynamics of torque teno virus load in kidney transplant recipients with indication biopsy and therapeutic modifications of immunosuppression

Reineke,

Morath,

Speer

et al. 2024

Front. Med.

View full text Add to dashboard Cite

Following kidney transplantation, lifelong immunosuppressive therapy is essential to prevent graft rejection. On the downside, immunosuppression increases the risk of severe infections, a major cause of death among kidney transplant recipients (KTRs). To improve post-transplant outcomes, adequate immunosuppressive therapy is therefore a challenging but vital aspect of clinical practice. Torque teno virus load (TTVL) was shown to reflect immune competence in KTRs, with low TTVL linked to an elevated risk for rejections and high TTVL associated with infections in the first year post-transplantation. Yet, little is known about the dynamics of TTVL after the first year following transplantation and how TTVL changes with respect to short-term modifications in immunosuppressive therapy. Therefore, we quantified TTVL in 106 KTRs with 108 clinically indicated biopsies, including 65 biopsies performed >12 months post-transplantation, and correlated TTVL to histopathology. In addition, TTVL was quantified at 7, 30, and 90 days post-biopsy to evaluate how TTVL was affected by changes in immunosuppression resulting from interventions based on histopathological reporting. TTVL was highest in patients biopsied between 1 and 12 months post-transplantation (N = 23, median 2.98 × 107 c/mL) compared with those biopsied within 30 days (N = 20, median 7.35 × 103 c/mL) and > 1 year post-transplantation (N = 65, median 1.41 × 104 c/mL; p < 0.001 for both). Patients with BK virus-associated nephropathy (BKVAN) had significantly higher TTVL than patients with rejection (p < 0.01) or other pathologies (p < 0.001). When converted from mycophenolic acid to a mTOR inhibitor following the diagnosis of BKVAN, TTVL decreased significantly between biopsy and 30 and 90 days post-biopsy (p < 0.01 for both). In KTR with high-dose corticosteroid pulse therapy for rejection, TTVL increased significantly between biopsy and 30 and 90 days post-biopsy (p < 0.05 and p < 0.01, respectively). Of note, no significant changes were seen in TTVL within 7 days of changes in immunosuppressive therapy. Additionally, TTVL varied considerably with time since transplantation and among individuals, with a significant influence of age and BMI on TTVL (p < 0.05 for all). In conclusion, our findings indicate that TTVL reflects changes in immunosuppressive therapy, even in the later stages of post-transplantation. To guide immunosuppressive therapy based on TTVL, one should consider inter- and intraindividual variations, as well as potential confounding factors.

show abstract

Obesity is associated with a higher Torque Teno viral load compared to leanness

Cited by 5 publications

References 45 publications

High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients

High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients

Evaluation of Torque Teno Virus DNA Load as a Predictive Biomarker in Kidney Transplant Recipients Converted from Calcineurin Inhibitors to Belatacept

Dynamics of torque teno virus load in kidney transplant recipients with indication biopsy and therapeutic modifications of immunosuppression

Contact Info

Product

Resources

About