Obesity is an initiator of colon adenomas but not a promoter of colorectal cancer in the Black Women’s Health Study

Dash, Chiranjeev; Yu, Jeffrey; Nomura, Sarah; Lu, Jiachen; Rosenberg, Lynn; Palmer, Julie R.; Adams‐Campbell, Lucile L.

doi:10.1007/s10552-020-01283-3

Cited by 17 publications

(22 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The suggestive inverse association between BMI and EO-CRC risk in our study contradicts results from the metaanalysis [15], as well as those from the Nurses' Health Study [17] and analyses of a large EHR database in the US [20,21], which reported increased risks associated with obesity. Similar to our study, a case-control study of US veterans reported an association between overweight/obesity and reduced risk of EO-CRC [24], while two other case-control studies [16,23] and a prospective cohort study of African American women [52] reported no associations. While weight loss may be an early symptom of CRC and a possible explanation for the inverse association observed between BMI and EO-CRC risk [24], it is unlikely since a similar association was also observed for BMI at early age 20s in our study.…”

Section: Discussionsupporting

confidence: 88%

Risk factors for early-onset colorectal cancer: a population-based case–control study in Ontario, Canada

Chang

Cotterchio

et al. 2021

Cancer Causes Control

View full text Add to dashboard Cite

Purpose There has been an alarming increase in colorectal cancer (CRC) incidence among young adults aged < 50 years, and factors driving this upward trend are unknown. This study investigated associations between various medical, lifestyle, and dietary factors and risk of early-onset CRC (EO-CRC). Methods A population-based case–control study was conducted in Ontario, Canada during 2018–2019. EO-CRC cases aged 20–49 years (n = 175) were identified from the Ontario Cancer Registry; sex- and age group-matched controls (n = 253) were recruited through random digit dialing. Data on potential a priori risk factors were collected using a web-based self-reported questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression. Results Family history of CRC in a first- or second-degree relative (OR 2.37; 95% CI 1.47–3.84), longer sedentary time (≥ 10 vs. < 5 h/day, OR 1.93; 95% CI 1.02–3.65), greater consumption of sugary drinks (≥ 7 vs. < 1 drinks/week, OR 2.99; 95% CI 1.57–5.68), and a more Westernized dietary pattern (quartile 4 vs. 1, OR 1.92; 95% CI 1.01–3.66) were each associated with an increased risk of EO-CRC. Conversely, calcium supplement use (OR 0.53; 95% CI 0.31–0.92), history of allergy or asthma (OR 0.62; 95% CI 0.39–0.98), and greater parity in females (≥ 3 vs. nulliparity, OR 0.29; 95% CI 0.11–0.76) were each associated with a reduced risk. Conclusion Modifiable factors, particularly sedentary behavior and unhealthy diet including sugary drink consumption, may be associated with EO-CRC risk. Our findings, if replicated, may help inform prevention strategies targeted at younger persons.

show abstract

Section: Discussionsupporting

confidence: 88%

Risk factors for early-onset colorectal cancer: a population-based case–control study in Ontario, Canada

Chang

Cotterchio

et al. 2021

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

“…[10][11][12] Given that early-onset CRC accounts for a minority of CRC cases only, it was unclear to what extent the observed associations would hold for CRC at young ages, the incidence of which has been increasing in many countries in recent years. 1,3,8,9 A few recent studies have specifically assessed associations of overweight and obesity with early-onset CRC, [15][16][17][18][24][25][26][27][28] but most typically evaluated BMI at 1 specific point of time only. On first view, results were rather mixed, ranging from strong positive [16][17][18]25 to null 24,26 or even inverse associations.…”

Section: Discussionmentioning

confidence: 99%

Associations of Body Mass Index at Different Ages With Early-Onset Colorectal Cancer

Boakye

Chen

et al. 2022

Gastroenterology

View full text Add to dashboard Cite

“…In addition to the microbiome, discussed above, obesity is a primary risk factor of interest for EOCRC. Recent literature has shown conflicting results for an obesity-EOCRC association, with a study from a primarily NHW population showing an obesity is associated with an increased EOCRC risk ( 9) and a study from a primarily NHB population showing no association (53). Thus, obesity may not explain the high rates of EOCRC in NHBs.…”

Section: Discussionmentioning

confidence: 99%

Racial Disparities and Sex Differences in Early- and Late-Onset Colorectal Cancer Incidence, 2001–2018

et al. 2021

Self Cite

View full text Add to dashboard Cite

BackgroundColorectal cancer (CRC) incidence rates have increased in younger individuals worldwide. We examined the most recent early- and late-onset CRC rates for the US.MethodsAge-standardized incidence rates (ASIR, per 100,000) of CRC were calculated using the US Cancer Statistics Database’s high-quality population-based cancer registry data from the entire US population. Results were cross-classified by age (20-49 [early-onset] and 50-74 years [late-onset]), race/ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic, American Indian/Alaskan Native, Asian/Pacific Islander), sex, anatomic location (proximal, distal, rectal), and histology (adenocarcinoma, neuroendocrine).ResultsDuring 2001 through 2018, early-onset CRC rates significantly increased among American Indians/Alaskan Natives, Hispanics, and Whites. Compared to Whites, early-onset CRC rates are now 21% higher in American Indians/Alaskan Natives and 6% higher in Blacks. Rates of early-onset colorectal neuroendocrine tumors have increased in Whites, Blacks, and Hispanics; early-onset colorectal neuroendocrine tumor rates are 2-times higher in Blacks compared to Whites. Late-onset colorectal adenocarcinoma rates are decreasing, while late-onset colorectal neuroendocrine tumor rates are increasing, in all racial/ethnic groups. Late-onset CRC rates remain 29% higher in Blacks and 15% higher in American Indians/Alaskan Natives compared to Whites. Overall, CRC incidence was higher in men than women, but incidence of early-onset distal colon cancer was higher in women.ConclusionsThe early-onset CRC disparity between Blacks and Whites has decreased, due to increasing rates in Whites—rates in Blacks have remained stable. However, rates of colorectal neuroendocrine tumors are increasing in Blacks. Blacks and American Indians/Alaskan Natives have the highest rates of both early- and late-onset CRC.ImpactOngoing prevention efforts must ensure access to and uptake of CRC screening for Blacks and American Indians/Alaskan Natives.

show abstract

Obesity is an initiator of colon adenomas but not a promoter of colorectal cancer in the Black Women’s Health Study

Cited by 17 publications

References 33 publications

Risk factors for early-onset colorectal cancer: a population-based case–control study in Ontario, Canada

Risk factors for early-onset colorectal cancer: a population-based case–control study in Ontario, Canada

Associations of Body Mass Index at Different Ages With Early-Onset Colorectal Cancer

Racial Disparities and Sex Differences in Early- and Late-Onset Colorectal Cancer Incidence, 2001–2018

Contact Info

Product

Resources

About