Obesity influences the microbiotic biotransformation of chlorogenic acid

Mortelé, Olivier; Xavier, Basil Britto; Christine, Lammens; Malhotra-Kumar, Surbhi; Philippe, Gailly; Dirinck, Eveline; Nuijs, Alexander L.N. van; Hermans, Nina

doi:10.1016/j.jpba.2021.114550

Cited by 1 publication

(3 citation statements)

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“…Chlorogenic acid is the phenolic compound of this category most frequently found in foods, including several fruits, coffee, potatoes and artichokes [ 32 , 33 , 34 ]. Ferulic acid and caffeic acid can be either less frequently found in foods of vegetal origin, or produced by the gut microbiota biotransformation of chlorogenic acid through two distinct metabolic pathways [ 70 , 71 ]. The bacterial species involved and the associated gut microbiota metabotypes are far less known than what happens for ellagitannins.…”

Section: Interaction Between Phenolic Compounds and Microbiota: Possi...mentioning

confidence: 99%

“…The bacterial species involved and the associated gut microbiota metabotypes are far less known than what happens for ellagitannins. The existing studies, in fact, were focused on metabolic transformations and not on microbiota [ 70 , 71 ]. However, there is substantial agreement that Bifidobacterium spp.…”

Section: Interaction Between Phenolic Compounds and Microbiota: Possi...mentioning

confidence: 99%

“…However, there is substantial agreement that Bifidobacterium spp. strains are strongly involved in these pathways [ 70 , 71 ].…”

Section: Interaction Between Phenolic Compounds and Microbiota: Possi...mentioning

confidence: 99%

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Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

et al. 2023

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Sarcopenia, the age-related loss of muscle mass and function increasing the risk of disability and adverse outcomes in older people, is substantially influenced by dietary habits. Several studies from animal models of aging and muscle wasting indicate that the intake of specific polyphenol compounds can be associated with myoprotective effects, and improvements in muscle strength and performance. Such findings have also been confirmed in a smaller number of human studies. However, in the gut lumen, dietary polyphenols undergo extensive biotransformation by gut microbiota into a wide range of bioactive compounds, which substantially contribute to bioactivity on skeletal muscle. Thus, the beneficial effects of polyphenols may consistently vary across individuals, depending on the composition and metabolic functionality of gut bacterial communities. The understanding of such variability has recently been improved. For example, resveratrol and urolithin interaction with the microbiota can produce different biological effects according to the microbiota metabotype. In older individuals, the gut microbiota is frequently characterized by dysbiosis, overrepresentation of opportunistic pathogens, and increased inter-individual variability, which may contribute to increasing the variability of biological actions of phenolic compounds at the skeletal muscle level. These interactions should be taken into great consideration for designing effective nutritional strategies to counteract sarcopenia.

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Section: Interaction Between Phenolic Compounds and Microbiota: Possi...mentioning

confidence: 99%

Section: Interaction Between Phenolic Compounds and Microbiota: Possi...mentioning

confidence: 99%

See 1 more Smart Citation

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

et al. 2023

View full text Add to dashboard Cite

show abstract

Obesity influences the microbiotic biotransformation of chlorogenic acid

Cited by 1 publication

References 33 publications

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

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