2023
DOI: 10.1590/1678-7757-2023-0133
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Obesity influences the development of bisphosphonate-induced osteonecrosis in Wistar rats

Wilson José de Miranda LIMA,
Jannerson Cesar Xavier de PONTES,
Ludmila Silva de FIGUEIREDO
et al.

Abstract: Medication-related osteonecrosis of the jaw (MRONJ) is characterized by bone exposure for more than eight weeks in patients who have used or been treated with antiresorptive or antiangiogenic drugs, without a history of radiation therapy or metastatic diseases in the jaws. Obesity is associated with changes in periodontal tissues and oral microbiota that are linked to bone alterations. This study aimed to analyze the influence of obesity on the development of bisphosphonate-induced osteonecrosis. The experimen… Show more

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