Abstract:Immunotherapy for advanced renal cell carcinoma (RCC) has shown tremendous promise. However, clinical responses remain <30% and the reasons are unclear. Obesity affects ~35% of U.S. adults and is a major risk factor for RCC. We reported previously that obesity impairs immunotherapeutic efficacy in a murine renal cancer model, due to increased myeloid suppressor cells and weakened effector CD8 T cell responses. Based on these results, we hypothesized that obesity would also induce detrimental shifts in t… Show more
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