Obesity in the Balinese is associated with FTO rs9939609 and rs1421085 single nucleotide polymorphisms

Priliani, Lidwina; Oktavianthi, Sukma; Hasnita, Ria; Nussa, Hazrina T.; Inggriani, Rut Christine; Febinia, Clarissa A.; Bowolaksono, Anom; Puspitaningrum, Rini; Nugroho, Rully Adi; Suastika, Ketut; Malik, Safarina G.

doi:10.7717/peerj.8327

Cited by 10 publications

(11 citation statements)

References 48 publications

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“…The minor allele frequency of FTO rs1421085 in our studied population (22%) is lower than our finding in Balinese (41%) [ 42 ]. The frequency is only slightly higher than Asian populations (13–14%, excluding South Asians), but lower than South Asian (31%) and European populations (42%) [ 43 , 44 ].…”

Section: Main Textcontrasting

confidence: 84%

“…FTO rs1421085 was genotyped using amplification-refractory mutation system polymerase chain reaction (ARMS PCR) as described by Priliani et al . [ 42 ] in a GeneAmp PCR System 9700 (Applied Biosystems, USA). PCR products were separated in 2% agarose gel electrophoresis (Lonza, Basel, Switzerland) and visualized using the Gel Doc XR Imaging System (BioRad, USA).…”

Section: Main Textmentioning

confidence: 99%

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Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

et al. 2021

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Objective Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models. Results Only individuals with the CC genotype had a considerably higher BMI (p < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45–4.06% across various genetic models (dominant: p < 0.010, over-dominant: p < 0.030, additive: p < 0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%, p = 0.046) and saturated fatty acid (SAFA; 2.06%, p = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between FTO rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA. This study highlights the important role of FTO gene in food preference, and its influence on body weight.

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confidence: 84%

Section: Main Textmentioning

confidence: 99%

Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

et al. 2021

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“…The minor allele frequency of FTO rs1421085 in our studied population (22%) is lower than our ndings in Balinese (41%) [34]. The frequency is only slightly higher than Asian populations (13-14%, excluding South Asians), but lower than South Asian (31%) and European populations (42%) [35,36].…”

Section: Discussioncontrasting

confidence: 71%

“…Archived DNA samples from our previous study [23] were assessed for quantity and purity using a Nanodrop-1000 (Perkin Elmer Biosystem, USA). FTO rs1421085 was genotyped with ampli cation-refractory mutation system polymerase chain reaction (ARMS PCR) using primer sets and PCR cycles described in Priliani et al [34] in a GeneAmp PCR System 9700 (Applied Biosystems, USA). PCR products were separated on 2% agarose gel electrophoresis (Lonza, Basel, Switzerland) and visualized using the Gel Doc XR Imaging System (BioRad, USA).…”

Section: Genotypingmentioning

confidence: 99%

Association of FTO rs1421085 Single Nucleotide Polymorphism With Fat and Fatty Acid Intake in Indonesian Adults

Al-Jawadi

Priliani

Oktavianthi

et al. 2021

Preprint

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ObjectiveRecent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. We genotyped FTO rs1421085 using amplification-refractory mutation system polymerase chain reaction (ARMS PCR). The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models.ResultsOnly individuals with CC genotype had a considerably higher BMI (p<0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT+TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45%—4.06% across various genetic models (dominant: p<0.010, over-dominant: p<0.030, additive: p<0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%, p = 0.046) and saturated fatty acid (SAFA; 2.06%, p = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between FTO rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA.

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“…2 Provinsi Bali memiliki prevalensi berat badan lebih dan obesitas diatas prevalensi nasional untuk remaja usia 13-15 tahun dan usia 16-18 tahun. 3 Obesitas menurut World Health Organisation (WHO) adalah suatu kondisi terjadinya akumulasi lemak berlebih dalam tubuh. 4 Obesitas pada masa remaja dapat berlanjut menjadi obesitas pada masa dewasa beserta komorbidnya.…”

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Gambaran profil lipid dan dislipidemia pada remaja dengan obesitas di kota Denpasar, Bali, Indonesia

Ns¹,

Arimbawa²

2020

Intisari Sains Medis

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Background: Obesity results in an increase fat accumulation in the body, related to blood lipid levels, and causes dyslipidemia. Dyslipidemia is one of the main risk factors for cardiovascular events. This study aims to determine the overview of lipid profiles and dyslipidemia in adolescents with obesity in the city of Denpasar, Bali, Indonesia.Method: A descriptive observational analytic study with a cross-sectional design was conducted on 51 obese adolescents in Denpasar using a two-stage random sampling technique. The variables assessed included examining lipid profiles such as total cholesterol, High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), and triglycerides. Data were analyzed with SPSS version 23 for Windows.Results: The results showed that there were 25 male subjects (49.01%) and 26 female subjects (50.99%) with an average age of 15.00Â±3.41 years. The mean body weight was 89.39Â±9.81 kg, the mean height was 158.62Â±7.31 cm, and the Body Mass Index (BMI) was 33.56Â±3.36 kg/m2. The mean total cholesterol 170.57 Â± 25.92 mg/dl, HDL 47.59 Â± 10.24 mg/dl, LDL 113.61 Â± 26.64 mg/dl, and triglycerides 126.14 (75.00) mg/dl. Dyslipidemia status based on criteria for total cholesterol levels was found in 27 subjects (52.9%), followed by HDL (23.59%), LDL (52.90%), and based on triglyceride levels of 15.70% subjects. Dyslipidemia based on the overall lipid profile was found in 36 subjects (70.60%).Conclusions: Most subjects had total cholesterol levels above normal, HDL levels below normal, LDL levels above normal, and most subjects experienced dyslipidemia.Â Latar belakang: Obesitas mengakibatkan peningkatan akumulasi lemak berlebihan dalam tubuh, berkaitan dengan kadar lipid darah dan menyebabkan terjadinya dislipidemia. Dislipidemia merupakan salah satu faktor resiko utama untuk terjadinya kardiovaskular. Penelitian ini bertujuan untuk mengetahui gambaran gambaran profil lipid dan dislipidemia pada remaja dengan obesitas di kota Denpasar, Bali, Indonesia.Metode: Penelitian observasioanal deskriptif dengan desain potong lintang dilakukan terhadap 51 remaja dengan obesitas di kota Denpasar menggunakan teknik two-stages random sampling. Variabel yang dinilai meliputi pemeriksan profil lipid seperti kolesterol total, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), dan trigliserida. Data dianalisis dengan SPSS versi 23 untuk Windows.Hasil: Hasil penelitian menunjukkan bahwa terdapat 25 subyek berjenis kelamin laki-laki (49,01%) dan 26 subyek perempuan (50,99%) dengan rerata usia 15,00Â±3,41 tahun. Rerata berat badan 89,39Â±9,81 kg, rerata tinggi badan 158,62Â±7,31 cm dan Indeks Massa Tubuh (IMT) 33,56Â±3,36 kg/m2. Rerata kolesterol total 170,57Â±25,92 mg/dl, HDL 47,59Â±10,24 mg/dl, LDL 113,61Â±26,64 mg/dl, dan trigliserida 126,14 (75,00) mg/dl. Status dislipidemia berdasarkan kriteria kadar kolesterol total didapatkan pada 27 subyek (52,9%), diikuti dengan HDL (23,59%), LDL (52,9%), dan berdasarkan kadar trigliserida sebesar 15,70% subyek. Dislipidemia berdasarkan keseluruhan profil lipid didapatkan pada 36 subyek (70,6%).Simpulan: Sebagian besar subyek memiliki kadar kolesterol total diatas normal, kadar HDL di bawah normal, kadar LDL di atas normal, dan sebagian besar subyek mengalami dislipidemia.

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Obesity in the Balinese is associated with FTO rs9939609 and rs1421085 single nucleotide polymorphisms

Cited by 10 publications

References 48 publications

Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

Association of FTO rs1421085 Single Nucleotide Polymorphism With Fat and Fatty Acid Intake in Indonesian Adults

Gambaran profil lipid dan dislipidemia pada remaja dengan obesitas di kota Denpasar, Bali, Indonesia

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