PURPOSE:The purpose of this work was to determine if racial differences in maximum oxygen uptake (VO 2 max) and difficulty in doing submaximum (sub) exercise tasks contribute to activity-related energy expenditure (AEE) and activity-related time equivalent (ARTE) index, an index of time spent in physical activity. METHODS: Subjects were 35 Black and 39 White sedentary premenopausal women group matched for age, weight and body composition. Percent fat was determined by dual energy X-ray absorptiometry, AEE by doubly labeled water and sleeping energy expenditure, ARTE index by AEE and energy cost above sleeping for five exercise tasks, and VO 2 max by a graded exercise test. Subexercise oxygen uptake was measured during walking at 3 mph on the flat and up a 2.5% grade, climbing stairs, and riding a bike ergometer at 50 W. Difficulty of exercise was assessed during the subexercise and taken as heart rate, ventilation, and ratings of perceived exertion (RPE) and expressed as a % of the individual's maximum. RESULTS: VO 2 max was related to AEE (r ¼ 0.29, Po0.04) and to ARTE index (r ¼ 0.37, Po0.01). All three difficulty measures were related to AEE (r ¼ À0.35 to À0.42, P-valueso0.02) and the ARTE index (r ¼ À0.49 to À0.52, all P-valueso0.01), with the exception of RPE with ARTE (r ¼ À0.27, P ¼ 0.10). Compared to Black women, White women had significantly higher VO 2 max (12%), AEE (45%) and ARTE (50%), and significantly less physiologic difficulty of performing the subexercise tasks: heart rate (5%), ventilation (13%), and RPE (8%). Significant racial differences in AEE and ARTE disappeared after adjusting for any of the three difficulty measures. CONCLUSIONS: These results show that more participation in free-living physical activity is related to greater VO 2 max and less difficulty in being active. In addition, lower levels of physical activity found in Black women may be partially explained by lower VO 2 max and increased difficulty of engaging in physical activities.