Obesity in Early Adulthood as a Risk Factor for Psoriatic Arthritis

Soltani-Arabshahi, Razieh; Wong, Bob; Feng, Bing; Goldgar, David E.; Duffin, Kristina Callis; Krueger, Gerald G.

doi:10.1001/archdermatol.2010.141

Cited by 148 publications

(130 citation statements)

References 31 publications

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“…There is a strong link between obesity and psoriatic disease. Obesity predicts the development of psoriasis and was also suggested to be associated with PsA 10 11 29 30. Obese patients tend to have more severe psoriasis and are less likely to respond to therapy 31–34.…”

Section: Discussionmentioning

confidence: 99%

Serum adipokines in patients with psoriatic arthritis and psoriasis alone and their correlation with disease activity

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Serum adipokines in patients with psoriatic arthritis and psoriasis alone and their correlation with disease activity

et al. 2012

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“…Obesity and a high body mass index (BMI) have been shown to be risk factors for the development of psoriasis, and in large, prospective studies obesity preceded the development of psoriasis [4]. More recently, obesity in adulthood has been shown to be a risk factor also for psoriatic arthritis [5]. On the other hand, once psoriasis has been established it may favor behaviors (e.g.…”

Section: Introductionmentioning

confidence: 99%

Weight Reduction Alone May Not Be Sufficient to Maintain Disease Remission in Obese Patients with Psoriasis: A Randomized, Investigator-Blinded Study

Giglio

Gisondi²,

Tessari³

et al. 2012

Dermatology

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Background: The relative risk of psoriasis and its severity are directly related to the body mass index. Objective: To investigate the effects of a hypoenergetic diet to maintain disease remission in obese patients. Methods: A questionnaire was administered to 200 patients with moderate-to-severe chronic plaque psoriasis asking whether diet could influence psoriasis severity. Forty-two obese patients in remission (PASI improvement ≥75%) for at least 12 weeks after methotrexate therapy were randomly assigned to receive a hypocaloric diet or free diet for 24 weeks, and were then followed up for an additional 12 weeks. Results: Most of the patients considered that a diet regimen could influence their psoriasis, and desired to enter a dietary program. Obese patients who were in disease remission and entered a hypocaloric diet regimen showed a significant body weight reduction after 12 weeks which was maintained at week 24. However, patients under hypocaloric and free diets did not significantly differ in the maintenance of psoriasis remission, with relapse observed already at week 12, but with a trend in favor of the intervention group. Conclusions: Body weight reduction alone may not be sufficient for maintaining remission of moderate-to-severe psoriasis in obese patients.

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“…Morbidity and mortality risk is associated with obese nutritional status due to the comorbidities of obesity (e.g., insulin resistance, glucose intolerance, diabetes mellitus, cardiovascular diseases, sleep apnea, arthritis, certain types of cancer) [59][60][61][62][63][64][65][66][67][68][69][70]. In addition, abdominal obesity was found to increase the prediction of health risk in obese nutritional status [71][72][73][74][75][76][77][78][79].…”

Section: Discussionmentioning

confidence: 99%

Body fatness and endogenous sex hormones in the menopausal transition

et al. 2016

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a b s t r a c tBackground: Age at the final menstrual period is of clinical and public health interest because the age at which natural menopause occurs may be a marker of ageing and health, and in general the menopausal transition increases the risk of many diseases, e.g. redistribution in the pattern of adiposity during the menopausal transition may increase risk of metabolic disease. The purpose of this research was to study the relationship between the menopausal status and body fatness. Subjects and methods: A random sample of 1932Hungarian women was studied. Body composition was estimated by body impedance analysis. In a subsample free estradiol and progesterone levels in saliva were quantified. Results: Body fat mass increased until the late 50s and then had a decrease through senescence. Premenopausal women who were much older than the median age at menopause had a higher amount of fat than their postmenopausal age-peers, while postmenopausal women, whose menopause occurred much earlier than the median age at menopause, had less fat than their premenopausal age-peers. The body fat mass in premenopausal women with low levels of sex hormones was always below the agemedian value of the menopausal status subgroups, while the body fat mass of postmenopausal women with high levels of sex hormone levels was above the age-median values. Conclusions: The analysis of body fatness in the menopausal transition revealed that (1) the rate of reproductive ageing and the body fat pattern were significantly related, and (2) body fat mass of women with unexpected levels of sex hormones was related more to their hormonal levels than to their menopausal status or their age. Thus future epidemiological screenings of women exposed to higher levels of menopause-related health risks should be expanded beyond the estimation of menopausal status based only on menstrual history to include sex hormone level assessment, as well as body composition analysis.

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Obesity in Early Adulthood as a Risk Factor for Psoriatic Arthritis

Cited by 148 publications

References 31 publications

Serum adipokines in patients with psoriatic arthritis and psoriasis alone and their correlation with disease activity

Serum adipokines in patients with psoriatic arthritis and psoriasis alone and their correlation with disease activity

Weight Reduction Alone May Not Be Sufficient to Maintain Disease Remission in Obese Patients with Psoriasis: A Randomized, Investigator-Blinded Study

Body fatness and endogenous sex hormones in the menopausal transition

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