Obesity in autoimmune diseases: Not a passive bystander

Versini, Mathilde; Jeandel, Pierre-Yves; Rosenthal, Éric; Shoenfeld, Yehuda

doi:10.1016/j.autrev.2014.07.001

Cited by 567 publications

(558 citation statements)

References 322 publications

Supporting

Mentioning

499

Contrasting

Unclassified

Order By: Relevance

“…Visfatin, first detected in skeletal muscles, liver and bone marrow, is encoded by the PBEF1 gene [41]. It is secreted by visceral fat tissue [42] and is implicated in a number of conditions, such as aging, atherosclerosis, pathogenesis of type 2 diabetes and rheumatoid arthritis [43]. Its role in metabolic processes is still controversial, but it has been reported that the properties of visfatin are similar to insulin.…”

Section: Visfatinmentioning

confidence: 99%

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Richter

Trzeciak

Owecki

et al. 2015

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

Osteoarthritis (OA) is one of the most common causes of musculoskeletal disability in the world. Traditionally, it has been thought that obesity contributes to the development and progression of OA by increased mechanical load of the joint structures. Nevertheless, studies have shown that adipose tissue-derived cytokines (adipocytokines) are a possible link between obesity and OA. Furthermore, according to recent findings, not only articular cartilage may be the main target of these cytokines but also the synovial membrane, subchondral bone and infrapatellar fat pad may be encompassed in the process of degradation. This review presents the most recent reports on the contribution of adipocytokines to the knee joint cartilage degradation, osteophyte formation, infrapatellar fat pad alterations and synovitis.

show abstract

Section: Visfatinmentioning

confidence: 99%

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Richter

Trzeciak

Owecki

et al. 2015

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

show abstract

“…Not all psoriasis patients are obese and not all obese individuals develop psoriasis [4]. Although the above population studies related psoriasis to obesity, they miss assessing other environmental factors that may contribute to the onset of psoriasis such as; trauma, medications, infections, smoking, alcohol, stress or mental health disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Further, obesity was found not only a risk of psoriasis (OR 1.48-6.46), but a major environmental factor contributing to the onset of autoimmune diseases such as rheumatoid arthritis (RA) (OR 1.2-3.4), multiple sclerosis (OR 2), and PsA (OR 1.48-6.46). It also worsens the course of RA, IBD, PsA and impairs the treatment response of RA, IBD, PsA, as well as psoriasis [4].…”

Section: Discussionmentioning

confidence: 99%

“…The answer to this question is still unknown as the precise mechanism underlying the association between psoriasis and obesity remains elusive [4]. Interestingly, two longitudinal prospective cohort studies found weight gain or obesity, particularly from the age of 18 years was a risk for developing psoriasis in women.…”

Section: Which Comes First; Obesity or Psoriasis?mentioning

confidence: 99%

“…There is no current cure for psoriasis and although the global prevalence of psoriasis is around 2% the disease incurs long term financial strain on the patient and on the health provider. International studies associated obesity with psoriasis incidence, severity and with diminish response to psoriasis systemic therapy [3,4]. Clinical trials and bariatric surgery conducted on obese psoriasis patients showed that weight reduction can improve psoriasis and its associated comorbidities [3].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Obesity and Psoriasis: Can Bariatric Surgery Trigger Psoriasis?

Aldeen¹,

Adebajo²

2015

Clin Exp Dermatol Res

View full text Add to dashboard Cite

Psoriasis is a chronic disfiguring incurable skin disease. It has been associated with comorbidities under the skin such as obesity, multiple metabolic, cardiovascular diseases and psychological disorders. Previous research reported that bariatric surgery for obese psoriatic patients can improve psoriasis and its comorbidities. In contrast, we report a case of morbidly obese diabetic patient who develop psoriasis after having a bariatric surgery to reduce his weight and review the association between psoriasis and obesity.

show abstract

Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition

Wang

Yuan

et al. 2023

JAMA Intern Med

View full text Add to dashboard Cite

ImportanceFew modifiable risk factors for post–COVID-19 condition (PCC) have been identified.ObjectiveTo investigate the association between healthy lifestyle factors prior to SARS-CoV-2 infection and risk of PCC.Design, Setting, and ParticipantsIn this prospective cohort study, 32 249 women in the Nurses’ Health Study II cohort reported preinfection lifestyle habits in 2015 and 2017. Healthy lifestyle factors included healthy body mass index (BMI, 18.5-24.9; calculated as weight in kilograms divided by height in meters squared), never smoking, at least 150 minutes per week of moderate to vigorous physical activity, moderate alcohol intake (5 to 15 g/d), high diet quality (upper 40% of Alternate Healthy Eating Index–2010 score), and adequate sleep (7 to 9 h/d).Main Outcomes and MeasuresSARS-CoV-2 infection (confirmed by test) and PCC (at least 4 weeks of symptoms) were self-reported on 7 periodic surveys administered from April 2020 to November 2021. Among participants with SARS-CoV-2 infection, the relative risk (RR) of PCC in association with the number of healthy lifestyle factors (0 to 6) was estimated using Poisson regression and adjusting for demographic factors and comorbidities.ResultsA total of 1981 women with a positive SARS-CoV-2 test over 19 months of follow-up were documented. Among those participants, mean age was 64.7 years (SD, 4.6; range, 55-75); 97.4% (n = 1929) were White; and 42.8% (n = 848) were active health care workers. Among these, 871 (44.0%) developed PCC. Healthy lifestyle was associated with lower risk of PCC in a dose-dependent manner. Compared with women without any healthy lifestyle factors, those with 5 to 6 had 49% lower risk (RR, 0.51; 95% CI, 0.33-0.78) of PCC. In a model mutually adjusted for all lifestyle factors, BMI and sleep were independently associated with risk of PCC (BMI, 18.5-24.9 vs others, RR, 0.85; 95% CI, 0.73-1.00, P = .046; sleep, 7-9 h/d vs others, RR, 0.83; 95% CI, 0.72-0.95, P = .008). If these associations were causal, 36.0% of PCC cases would have been prevented if all participants had 5 to 6 healthy lifestyle factors (population attributable risk percentage, 36.0%; 95% CI, 14.1%-52.7%). Results were comparable when PCC was defined as symptoms of at least 2-month duration or having ongoing symptoms at the time of PCC assessment.Conclusions and RelevanceIn this prospective cohort study, pre-infection healthy lifestyle was associated with a substantially lower risk of PCC. Future research should investigate whether lifestyle interventions may reduce risk of developing PCC or mitigate symptoms among individuals with PCC or possibly other postinfection syndromes.

show abstract

Obesity in autoimmune diseases: Not a passive bystander

Cited by 567 publications

References 322 publications

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Obesity and Psoriasis: Can Bariatric Surgery Trigger Psoriasis?

Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition

Contact Info

Product

Resources

About