Obesity in Association of Autoimmune Thyroid Diseases and Type 2 Diabetes

Marmouch, H.; Jenzri, H.; Abdallah, B.; Tahri, S.; Charrada, I.; Khochtali, I.

doi:10.1016/j.metabol.2020.154560

Cited by 1 publication

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“…To this end, we established novel quantitative aAb assays to human MCT8 and in parallel to the highly related MCT10 molecule, and assessed the prevalence of MCT8-aAb and MCT10-aAb in three groups of subjects, i.e., healthy adults, overweight adolescents and thyroid patients. The inclusion of a group of obese subjects was of particular relevance, as obesity increases the risk for autoimmunity due to the interference of fat-derived adipokines with the immune system [16][17][18][19], and the potential consequence of autoimmune thyroid disease and a suppressed TH status causing weight gain and diabetes risk [20][21][22]. The rationale for choosing these groups of subjects lies in the hypothesis that inhibitory aAb to MCT8 or MCT10 would modify thyroid gland function, TH status and energy homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10

et al. 2021

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The monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are important for thyroid hormone (TH) uptake and signaling. Reduced TH activity is associated with impaired development, weight gain and discomfort. We hypothesized that autoantibodies (aAb) to MCT8 or MCT10 are prevalent in thyroid disease and obesity. Analytical tests for MCT8-aAb and MCT10-aAb were developed and characterized with commercial antiserum. Serum samples from healthy controls, thyroid patients and young overweight subjects were analyzed, and prevalence of the aAb was compared. MCT8-aAb were additionally tested for biological effects on thyroid hormone uptake in cell culture. Positive MCT8-aAb and MCT10-aAb were detected in all three clinical cohorts analyzed. MCT8-aAb were most prevalent in thyroid patients (11.9%) as compared to healthy controls (3.8%) and overweight adolescents (4.2%). MCT8-aAb positive serum reduced T4 uptake in cell culture in comparison to MCT8-aAb negative control serum. Prevalence of MCT10-aAb was highest in the group of thyroid patients as compared to healthy subjects or overweight adolescents (9.0% versus 4.5% and 6.3%, respectively). We conclude that MCT8 and MCT10 represent autoantigens in humans, and that MCT8-aAb may interfere with regular TH uptake and signaling. The increased prevalence of MCT8-aAb and MCT10-aAb in thyroid disease suggests that their presence may be of pathophysiological relevance. This hypothesis deserves an analysis in large prospective studies.

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