Obesity

Rosenblum, Jennifer; Venkatesh, Rajitha D.

doi:10.1007/978-3-319-45778-9_8

Cited by 1 publication

(1 citation statement)

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“…Surgical techniques aiming at weight loss comprise sleeve gastrectomy, gastric banding and gastric bypass surgery. 6 Gastric bypass surgery is one of the most commonly employed weight loss techniques with average weight loss of around 50%–70% of excess body weight. 7 8 The Roux-en-Y gastric bypass (RYGB) surgery is an irreversible procedure and is the most frequently applied bariatric technique.…”

Section: Introductionmentioning

confidence: 99%

Impact of bariatric surgery on neural food processing and cognition: an fMRI study

et al. 2018

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IntroductionThe Roux-en-Y gastric bypass (RYGB) is one of the most widely used techniques for bariatric surgery. After RYGB, weight loss up to 50%–70% of excess body weight, improvement of insulin-resistance, changes in food preferences and improvements in cognitive performance have been reported. This protocol describes a longitudinal study of the neural correlates associated with food-processing and cognitive performance in patients with morbid obesity before and after RYGB relative to lean controls.Methods and analysisThis study is a pre–post case–control experiment. Using functional MRI, the neural responses to food stimuli and a working memory task will be compared between 25 patients with obesity, pre and post RYGB, and a matched, lean control group. Resting state fMRI will be measured to investigate functional brain connectivity. Baseline measurements for both groups will take place 4 weeks prior to RYGB and 12 months after RYGB. The effects of RYGB on peptide tyrosine tyrosine and glucagon-like polypeptide-1 will also be determined.Ethics and disseminationThe project has received ethical approval by the local medical ethics committee of the Carl-von-Ossietzky University of Oldenburg, Germany (registration: 2017-073). Results will be published in a peer-reviewed journal as original research and on international conferences.Trial registration numberDRKS00012495; Pre-results.

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Section: Introductionmentioning

confidence: 99%