Obesity during pregnancy and fetal iron status: is Hepcidin the link?

Dao, Maria Carlota; Sen, Sarbattama; Iyer, Chitra; Klebenov, David; Meydani, Simin Nikbin

doi:10.1038/jp.2012.81

Cited by 88 publications

(139 citation statements)

References 19 publications

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“…Of note, Tussing-Humphreys et al (46) found substantially higher serum hepcidin and CRP, together with lower iron status in obese versus lean women. Similar results were reported in other adult cohorts, as well as children (53,55,57), and pregnant women (54). As to the latter, we recently found higher hepcidin and CRP levels in obese pregnant women compared with lean pregnant women (54).…”

Section: Current Status Of Knowledgesupporting

confidence: 75%

“…Similar results were reported in other adult cohorts, as well as children (53,55,57), and pregnant women (54). As to the latter, we recently found higher hepcidin and CRP levels in obese pregnant women compared with lean pregnant women (54). Iron status markers did not differ between the mothers, but they did for the newborns, with lower transferrin saturation (Tsat) and serum iron in cord blood from the obese group.…”

Section: Current Status Of Knowledgesupporting

confidence: 72%

“…Obesity is characterized by low-grade chronic inflammation, that is, an increase in circulating inflammatory molecules, such as IL-6 and CRP (52), which in turn is associated with chronic disease risk. In recent years, studies have shown an association between hepcidin, chronic inflammation, and low iron status in obese populations (15,46,(53)(54)(55)(56)(57), identifying a possible mechanism by which iron status impairment occurs in the obese ( Table 2). These studies consistently showed an association between serum hepcidin, inflammation, and low iron status.…”

Section: Current Status Of Knowledgementioning

confidence: 99%

“…Dao et al (54) 2012 Obese (n = 15) and lean (n = 15) pregnant women. Cord blood from obese (n = 8) and lean (n = 9) group (United States) BMI, and maternal and cord blood iron status (sFe, Tsat, ferritin, Hb, HCT), CRP, and IL-6…”

Section: Key Findingsmentioning

confidence: 99%

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Iron Biology, Immunology, Aging, and Obesity: Four Fields Connected by the Small Peptide Hormone Hepcidin

Dao

Meydani

2013

Advances in Nutrition

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Iron status and immune response become impaired in situations that involve chronic inflammation, such as obesity or aging. Little is known, however, about the additional burden that obesity may place on the iron status and immune response in the elderly. This question is relevant given the rising numbers of elderly obese (BMI >30 kg/m 2 ) individuals and the high prevalence of iron deficiency worldwide. Iron is necessary for proper function of both the innate and adaptive immune system. Hepcidin, a peptide hormone that regulates cellular iron export, is essential for the maintenance of iron homeostasis. Therefore, since immune cells require iron for proper function hepcidin may also play an important role in immune response. In this review, we summarize the evidence for hepcidin as a link between the fields of gerontology, obesity, iron biology, and immunology. We also identify several gaps in knowledge and unanswered questions pertaining to iron homeostasis and immunity in obese populations. Finally, we review studies that have shown the impact of weight loss, focusing on calorie restriction, iron homeostasis, and immunity. These studies are important both in elucidating mechanistic links between obesity and health impairments and identifying possible approaches to target immune impairment and iron deficiency as comorbidities of obesity.

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Section: Current Status Of Knowledgesupporting

confidence: 75%

Section: Current Status Of Knowledgesupporting

confidence: 72%

Section: Current Status Of Knowledgementioning

confidence: 99%

Section: Key Findingsmentioning

confidence: 99%

See 2 more Smart Citations

Iron Biology, Immunology, Aging, and Obesity: Four Fields Connected by the Small Peptide Hormone Hepcidin

Dao

Meydani

2013

Advances in Nutrition

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“…Maternal obesity disrupts iron transfer to the fetus owing to the increase in the level of hepcidin, in particular, and to the effect of a pro-inflammatory medium. Due to these changes, anemia often occurs in maternal obesity (57). …”

Section: Introductionmentioning

confidence: 99%

Maternal Obesity and its Short- and Long-Term Maternal and Infantile Effects

Korkmaz¹,

Baştuğ²,

Kurtoğlu³

2016

Jcrpe

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Obesity, in childhood or in adulthood, remains to be a global health problem. The worldwide prevalence of obesity has increased in the last few decades, and consequently, the women of our time suffer more gestational problems than women in the past. The prevalence of obesity is greater in older women than in younger ones and in women with low educational level than in their counterparts with a higher level of education. Maternal obesity during pregnancy may increase congenital malformations and neonatal morbidity and mortality. Maternal obesity is associated with a decreased intention to breastfeed, decreased initiation of breastfeeding, and decreased duration of breastfeeding. We discuss the current epidemiological evidence for the association of maternal obesity with congenital structural neural tube and cardiac defects, fetal macrosomia that predisposes infants to birth injuries and to problems with physiological and metabolic transition, as well as potential for long-term complications secondary to prenatal and neonatal programming effects compounded by a reduction in sustained breastfeeding.

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The reproductive ecology of iron in women

Miller

2016

American J Phys Anthropol

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Reproductive ecology focuses on the sensitivity of human reproduction to environmental variation. While reproductive ecology has historically focused on the relationship between energy status and reproductive outcomes, iron status is equally critical to women's reproductive health, given the wide-ranging detrimental effects of iron-deficiency anemia on maternal and infant well-being. This review interprets the vast literature on iron status and women's reproduction through an evolutionary framework. First, it will critique the evidence for iron deficiency caused by blood loss during menstruation, reinterpreting the available data as ecological variation in menses within and between populations of women. Second, it will highlight the scant but growing evidence that iron status is implicated in fertility, a relationship that has deep evolutionary roots. Third, this review proposes a new hypothesis for the transfer of iron from mother to infant via pregnancy and breastfeeding: reproductive iron withholding. In this hypothesis, mothers transfer iron to infants in a manner that helps infants avoid iron-mediated infection and oxidative stress, but trades off with potential risk of maternal and infant iron deficiency. Finally, this review explores two main factors that can modify the relationship between iron status and the gestation-lactation cycle: (1) the relationship between long-term reproductive effort (parity) and iron status and (2) supplementation schemes before and during pregnancy. The review concludes by suggesting continued research into iron homeostasis in women using evolutionary, ecological, and biocultural frameworks. Am J Phys Anthropol 159:S172-S195,

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Obesity during pregnancy and fetal iron status: is Hepcidin the link?

Cited by 88 publications

References 19 publications

Iron Biology, Immunology, Aging, and Obesity: Four Fields Connected by the Small Peptide Hormone Hepcidin

Iron Biology, Immunology, Aging, and Obesity: Four Fields Connected by the Small Peptide Hormone Hepcidin

Maternal Obesity and its Short- and Long-Term Maternal and Infantile Effects

The reproductive ecology of iron in women

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