Obesity-Diabetes and Anorexigenics

Abstract

Previous observations on 62 obese diabetic patients showed that phenmetrazine hydrochloride significantly reduced appetite and weight. In the present study 30

To Depress the Craving for Food

“…Some studies, however, have shown that phenmetrazine was much superior to either phendimetrazine or diethylpropion in producing weight loss. In these same studies, it was reported that phenmetrazine and phendimetrazine produced the same incidence of side effects, while diethylpropion produced fewer side effects (9,10).…”

Anorexigenic Drugs in Perspective

“…These were the inclusion of low‐caloric diets and particularly the psychologic impact of the physician‐investigator on the patient and the investigator's own conscious or unconscious bias. Gradually these undesirable features were reduced or neutralized by the evolution of more sophisticated, better‐controlled studies with double‐blind, cross‐over and total randomization factors (8–13). As the validity of the methodologies increased, the clinical evidence for the pharmacologic activity and hypo‐orexigenic quality of these drugs mounted.…”

“…As the validity of the methodologies increased, the clinical evidence for the pharmacologic activity and hypo‐orexigenic quality of these drugs mounted. Eventually a method was derived which demonstrated an involuntary decrease in appetite in humans, with almost the same degree of objectivity as is attained in animal experiments (10, 13, 14). This was effected by the introduction of a very significant third blind factor.…”

“…Anorexigenic agents are available which produce excellent appetite suppression in a very high percentage of cases when skillfully used (8, 9, 13, 14, 27, 28). An optimal effect is obtained with short‐acting forms taken one to two hours before meals thus timing the activity to reach its height at mealtime.…”

“…The symptoms produced by caloric restriction will be reduced considerably by this method of alternating food and medication. The low incidence of side effects requiring discontinuation of these drugs [about 5–15 per cent (10, 13, 14)] can be lowered even further by a decrease in the dosage or combination with a sedative or tranquilizer.…”