Obesity could shift severe COVID-19 disease to younger ages

Kass, David A.; Duggal, Priya; Cingolani, Oscar H.

doi:10.1016/s0140-6736(20)31024-2

Cited by 396 publications

(405 citation statements)

References 4 publications

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“…Data from the present study are also consistent with recent reports of an inverse relationship between age and BMI among patients with COVID-19 who were admitted to the intensive care setting (see Fig. 1) (23). However, contrary to recent reports (24,25), no signi cant association was found between BMI and mortality in the present study.…”

Section: Discussionsupporting

confidence: 90%

Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection

Maguire

Woods

Richards

et al. 2020

Preprint

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Abstract BackgroundSevere COVID-19 infection results in a systemic inflammatory response (SIRS). This SIRS response shares similarities to the changes observed during the peri-operative period that are recognised to be associated with the development of multiple organ failure. MethodsElectronic patient records for patients who were admitted to an urban teaching hospital during the initial 7-week period of the COVID-19 pandemic in Glasgow, U.K. (17th March 2020 - 1st May 2020) were examined for routine clinical, laboratory and clinical outcome data. Age, sex, BMI and documented evidence of COVID-19 infection at time of discharge or death certification were considered minimal criteria for inclusion.ResultsOf the 224 patients who fulfilled the criteria for inclusion, 52 (23%) had died at 30-days following admission. COVID-19 related respiratory failure (75%) and multiorgan failure (12%) were the commonest causes of death recorded. Age>70 years (p<0.001), past medical history of cognitive impairment (p<0.001), previous delirium (p<0.001), clinical frailty score>3 (p<0.001), hypertension (p<0.05), heart failure (p<0.01), national early warning score (NEWS) >4 (p<0.01), positive CXR (p<0.01), and subsequent positive COVID-19 swab (p<0.001) were associated with 30-day mortality. CRP>80 mg/L (p<0.05), albumin <35g/L (p<0.05), peri-operative Glasgow Prognostic Score (poGPS) (p<0.05), lymphocytes <1.5 109/l (p<0.05), neutrophil lymphocyte ratio (p<0.001), haematocrit (<0.40 L/L (male) / <0.37 L/L (female)) (p<0.01), urea>7.5 mmol/L (p<0.001), creatinine >130 mmol/L (p<0.05) and elevated urea: albumin ratio (<0.001) were also associated with 30-day mortality.On analysis, age >70 years (O.R. 3.9, 95% C.I. 1.4 – 8.2, p<0.001), past medical history of heart failure (O.R. 3.3, 95% C.I. 1.2 – 19.3, p<0.05), NEWS >4 (O.R. 2.4, 95% C.I. 1.1 – 4.4, p<0.05), positive initial CXR (O.R. 0.4, 95% C.I. 0.2-0.9, p<0.05) and poGPS (O.R. 2.3, 95% C.I. 1.1 – 4.4, p<0.05) remained independently associated with 30-day mortality. Among those patients who tested PCR COVID-19 positive (n=122), age >70 years (O.R. 4.7, 95% C.I. 2.0 - 11.3, p<0.001), past medical history of heart failure (O.R. 4.4, 95% C.I. 1.2 – 20.5, p<0.05) and poGPS (O.R. 2.4, 95% C.I. 1.1- 5.1, p<0.05) remained independently associated with 30-days mortality.ConclusionAge > 70 years and severe systemic inflammation as measured by the peri-operative Glasgow Prognostic Score are independently associated with 30-day mortality among patients admitted to hospital with COVID-19 infection.

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Section: Discussionsupporting

confidence: 90%

Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection

Maguire

Woods

Richards

et al. 2020

Preprint

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“…It has been well publicised that outcomes following COVID-19 are worse in individuals who are obese or live a sedentary lifestyle. 28,29 For most people, lifestyle changes are rarely maintained from positive intention alone. However, decisive change is often triggered by a specific event, experience or consequence, referred to as the 'Sentinel Event Effect'.…”

Section: Patient Perceptionsmentioning

confidence: 99%

Implications for the future of Obstetrics and Gynaecology following the COVID‐19 pandemic: a commentary

Kasaven

Saso

Barcroft

et al. 2020

BJOG

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“…Adipositas ist jedoch ein wichtiger Risikofaktor für einen schweren COVID-19-Verlauf. In PatientInnenkollektiven mit großem Anteil von Menschen mit Adipositas ist auch das Durchschnittsalter der Betroffenen niedriger als üblicherweise beschrieben [39]. Eine kausale Beziehung zwischen Adipositas und dem schwereren Krankheitsverlauf kann derzeit nicht abgeleitet werden.…”

Section: Adipositas Ist Risikofaktor Für Einen Schweren Krankheitsverunclassified

Bedeutung der SARS-CoV-2-Pandemie für Menschen mit Adipositas

Gerlach¹,

Blüher²,

Engeli

et al. 2020

Adipositas - Ursachen, Folgeerkrankungen, Therapie

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Zusammenfassung Ziel Analyse des derzeitigen Wissens zur Bedeutung der SARS-CoV-2-Pandemie für Menschen mit Adipositas. Formulierung von Gesundheitsempfehlungen der Deutschen Adipositas-Gesellschaft. Methodik Selektive Literatursuche in PubMed und Internetrecherche. Ergebnisse Derzeit gibt es keine belastbaren Hinweise, dass Menschen mit Adipositas ein erhöhtes SARS-CoV-2-Infektionsrisiko aufweisen. Adipositas ist jedoch ein wichtiger Risikofaktor für einen schweren COVID-19-Verlauf. Eine kausale Beziehung zwischen Adipositas und schwerem Krankheitsverlauf kann derzeit allerdings nicht abgeleitet werden. Jedoch zeigt die COVID-19-Situation, dass PatientInnen mit Adipositas bei Intensiv- und Beatmungspflichtigkeit klinisch in der Regel schwer zu führen sind. Schlussfolgerungen Die DAG rät Menschen mit Adipositas, die empfohlenen Hygieneregeln und Maßnahmen des Infektionsschutzgesetzes sowie der Kontaktbeschränkungen sorgfältig zu befolgen. Darüber hinaus sollten grundlegende Empfehlungen zum Gesundheitsschutz und zu einem gesunden Lebensstil beachtet werden.

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Obesity could shift severe COVID-19 disease to younger ages

Cited by 396 publications

References 4 publications

Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection

Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection

Implications for the future of Obstetrics and Gynaecology following the COVID‐19 pandemic: a commentary

Bedeutung der SARS-CoV-2-Pandemie für Menschen mit Adipositas

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