Obesity, cigarette smoking, and telomere length in women

Valdes, Ana M.; Andrew, Toby; Gardner, J. P.; Kimura, Masayuki; Oelsner, Elizabeth C.; Cherkas, Lynn; Aviv, Abraham; Spector, Tim D.

doi:10.1016/s0140-6736(05)66630-5

Cited by 1,242 publications

(1,148 citation statements)

References 5 publications

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“…In contrast with our observations, two studies on healthy female twins aged 18-75 years, from the St Thomas' (Twins UK) Twin Registry, showed that short telomeres were associated with BMI and smoking. 19,20 Similar observations were recently made in young (mean age 31.4-37.4 years) whites and African Americans participating in the Bogalusa Heart Study. 21 Associations between BMI, smoking and telomere length may be obscured by several factors known to affect telomere length, Telomere length in the LIFE studyincluding gender, age and cardiovascular disease.…”

Section: Men Womensupporting

confidence: 73%

Telomere length and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study

et al. 2011

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Short telomeres are associated with aging and agerelated diseases. Our aim was to determine whether short leukocyte telomere length is associated with risk factors and cardiovascular diseases in a high-risk hypertensive population. We measured leukocyte telomere lengths at recruitment in 1271 subjects with hypertension and left ventricular hypertrophy (LVH) participating in the Lifestyle Interventions and Independence for Elders (LIFE) study. At baseline, short mean telomere length was associated with coronary artery disease in males (odds ratio (OR) 0.61, 95% confidence interval (CI) 0.39-0.95), and transient ischemic attack in females (OR 0.62 95% CI 0.39-0.99). Proportion of short telomeres (shorter than 5 kb) was associated with Framingham risk score (r ¼ 0.07, Po0.05), cerebrovascular disease (OR 1.18, 95% CI 1.01-1.15) and type 2 diabetes in men (OR 1.07, 95% CI 1.02-1.11). During follow-up, proportion of short telomeres was associated with combined cardiovascular mortality, stroke or angina pectoris (hazard ratio 1.04, 95% CI 1.01-1.07). Telomere length was not associated with smoking, body mass index, pulse pressure or selfreported use of alcohol. Our data suggest that reduced leukocyte telomere length is associated with cardiovascular risk factors and diseases as well as type 2 diabetes, and is a predictor of cardiovascular disease in elderly patients with hypertension and LVH.

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Section: Men Womensupporting

confidence: 73%

Telomere length and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study

et al. 2011

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“…13 Recent genome-wide association studies have shown that genetic variation within the gene encoding for the telomerase RNA component (TERC) affects LTL in humans, 14,15 and several other genes have been identified, but all of the findings are not replicated in independent samples yet. Accelerated telomere shortening has also been associated with environmental and lifestyle factors, including smoking, 16 physical inactivity, 17 psychological stress 18 and low socio-economic status. 19 Oxidative stress has been found to be associated with telomere attrition.…”

Section: Introductionmentioning

confidence: 99%

Leukocyte telomere length and its relation to food and nutrient intake in an elderly population

Männistö

et al. 2012

Eur J Clin Nutr

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BACKGROUND/OBJECTIVES: Shorter leukocyte telomere length (LTL) is associated with several chronic diseases, but only a few studies have assessed the association between dietary factors and LTL. Our objective was to study the association between fats, fruits, vegetables and LTL in a cross-sectional study design. We hypothesized that intakes of fruits and vegetables would be positively associated with LTL and that intakes of fats, and especially saturated fatty acids (SFAs), would be negatively associated with LTL. SUBJECTS/METHODS: LTL was measured by quantitative real-time polymerase chain reaction in 1942 men and women aged 57-70 years from the Helsinki Birth Cohort Study. We assessed the whole diet by a validated semiquantitative 128-item food-frequency questionnaire. RESULTS: In general, there were only a few significant results. However, total fat and SFA intake (P ¼ 0.04 and 0.01, respectively) were inversely associated with LTL in men adjusting for age and energy intake. In women, vegetable intake was positively associated with LTL (P ¼ 0.05). Men consuming the most butter and least fruits had significantly shorter telomeres than those consuming the lowest amounts of butter and highest amounts of fruits (P ¼ 0.05). We found no association between LTL and body mass index, waist-hip ratio, smoking, physical activity or educational attainment. CONCLUSIONS: In this cross-sectional study of elderly men and women, there were only a few statistically significant effects of diet, but in general they support the hypothesis that fat and vegetable intakes were associated with LTL.

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“…Though highly variable, it is heritable [1][2][3][4][5][6] and longer in women than men [1,3,4,[6][7][8][9]. Environmental factors, including smoking [3,10], obesity [9][10][11], psychological stress [12] and low socio-economic status (SES) [13] are ostensibly associated with shortened LTL, underscoring the roles of not only genetic factors but also the environment in fashioning leukocyte telomere dynamics (length and attrition rate). Shortened LTL is also observed in individuals with aging-related diseases, including hypertension [1,7], insulin resistance [11,14,15], atherosclerosis [16,17], myocardial infarction [16,18,19], stroke [9] and dementia [20,21].…”

Section: Introductionmentioning

confidence: 99%

Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm

Kimura¹,

Cherkas²,

Kato³

et al. 2005

PLoS Genet

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Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of agingrelated disorders. Recent studies have observed that offspring of older fathers have longer LTLs. We explored the relation between paternal age and offspring's LTLs in 4 different cohorts. Moreover, we examined the potential cause of the paternal age on offspring's LTL by delineating telomere parameters in sperm donors. We measured LTL by Southern blots in Caucasian men and women (n¼3365), aged 18-94 years, from the Offspring of the Framingham Heart Study (Framingham Offspring), the NHLBI Family Heart Study (NHLBI-Heart), the Longitudinal Study of Aging Danish Twins (Danish Twins), and the UK Adult Twin Registry (UK Twins). Using Southern blots, Q-FISH, and flow-FISH, we also measured telomere parameters in sperm from 46 young (,30 years) and older (.50 years) donors. Paternal age had an independent effect, expressed by a longer LTL in males of the Framingham Offspring and Danish Twins, males and females of the NHLBI-Heart, and females of UK Twins. For every additional year of paternal age, LTL in offspring increased at a magnitude ranging from half to more than twice of the annual attrition in LTL with age. Moreover, sperm telomere length analyses were compatible with the emergence in older men of a subset of sperm with elongated telomeres. Paternal age exerts a considerable effect on the offspring's LTL, a phenomenon which might relate to telomere elongation in sperm from older men. The implications of this effect deserve detailed study.Citation: Kimura M, Cherkas LF, Kato BS, Demissie S, Hjelmborg JB, et al. (2008) Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genet 4(2): e37.

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Obesity, cigarette smoking, and telomere length in women

Cited by 1,242 publications

References 5 publications

Telomere length and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study

Telomere length and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study

Leukocyte telomere length and its relation to food and nutrient intake in an elderly population

Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm

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