Obesity augmented breast cancer risk: A potential risk factor for Indian women

Singh, Alok Kumar; Pandey, Abha; Tewari, Mallika; Pratyush, Daliparthy D.; Singh, Hemant Kumar; Pandey, Harsh; Shukla, H. S.

doi:10.1002/jso.21768

Cited by 21 publications

(13 citation statements)

References 41 publications

(43 reference statements)

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“…They found no association in the ERÀ/PRÀ subgroup. Althuis et al 4 in their review of the literature, Chen et al 3 in their meta-analysis and more recently Kawai et al, 25 Parr et al 26 and Singh et al 27 also concluded to an increased risk of postmenopausal breast cancers associated with high BMI; this risk was more pronounced for cancers with positive receptors than those with negative receptors. It has been suggested that risk factors associated with ER þ /PR þ breast cancer may operate through exposure to estrogen and progesterone, unlike those associated with ERÀ/PRÀ breast cancer, which may involve mechanisms independent of steroid exposure.…”

Section: Height and Breast Cancer Riskmentioning

confidence: 99%

Hip circumference is associated with the risk of premenopausal ER−/PR− breast cancer

et al. 2011

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Objective: We evaluated the relationship between hip and waist circumferences (HCs, WCs), waist-to-hip ratio, height, weight and body mass index (BMI) and breast cancer risk according to menopausal status of women and cancer hormone receptor status. Design: We used data from the French E3N longitudinal prospective cohort. Subjects: In the total population of 63 726 women who were analyzed, 1887 breast cancer cases were diagnosed during follow-up. Results: Among postmenopausal women, the risk of ER þ /PR þ breast cancer increased with increasing weight, BMI, and both HCs and WCs, although these two associations disappeared after adjustment for BMI. No association was seen with ERÀ/PRÀ breast cancers. Among premenopausal women, among the different factors studied, HC only (no association was observed for any of the different factors studied except for HC) was associated with an increased risk of ER þ /PR þ breast cancer after adjustment for BMI (hazard ratio (HR) ¼ 1.65; (1.04-2.62) when comparing the highest to lowest tertile; P-trend across tertiles ¼ 0.03) and of ERÀ/PRÀ breast cancer both before and after adjustment for BMI (HR ¼ 2.85 (1.33-6.13); P-trend o0.01, and HR ¼ 3.13 (1.19-8.27) P-trend ¼ 0.02, respectively). In the latter group, the association with HC was observed whatever the WC (HR ¼ 2.81 (1.18-6.70) and HR ¼ 2.79 (1.16-6.76) in women with high HC/low WC and high HC/high WC, respectively). Conclusion: The increase in risk of premenopausal breast cancer associated with large HC for both ER þ /PR þ and ERÀ/PRÀ subtypes may provide insight into a specific risk factor for premenopausal breast cancer.

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Section: Height and Breast Cancer Riskmentioning

confidence: 99%

Hip circumference is associated with the risk of premenopausal ER−/PR− breast cancer

et al. 2011

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“…Steering committee (WHO Western Pacific Region, 2000; 16 the international association for the study of obesity and international obesity task force) recommended the cutoff for overweight (!23 kg/m 2 ) and obesity (!25 kg/m 2 ) for Asians. However, the exact classification criteria are shown in Table 1.…”

Section: Estimation Of Bmimentioning

confidence: 99%

“…However, the exact classification criteria are shown in Table 1. 15,16 BMI was measured at the time of hospital admission for treatment and the above criteria were used to categorize patients.…”

Section: Estimation Of Bmimentioning

confidence: 99%

Prolonged elevated postprandial sugar augments severity in kidney disease: a North Indian hospital-based study

Singh

Das

et al. 2013

Renal Failure

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Aim: Diabetes plays a major role in progression of renal failure. The risk-factor profile changes during the progression of chronic kidney disease (CKD) from mild/moderate to end-stage renal disease. The relationship between glycemic indices, blood pressure, body mass index (BMI) and age at diagnosis in Indians has been less investigated. We assessed association of these risk factors with CKD stages in Indian population. Methods: This study was carried out on patients (n ¼ 162) who were diagnosed with CKD and normal control group (n ¼ 155). For BMI, National Institutes for Health criteria were used to categorize the patients. Result: The mean age of CKD patients were significantly increased with the advancement of stage. BMI, systolic blood pressure (SBP), postprandial sugar level (PP), urea and creatinine were also significantly higher with elevated stages, whereas no differences were observed in diastolic blood pressure (DBP) and fasting blood sugar (FBS). The logistic regression study gave a significant result (p ¼ 0.000) when we compared the group of CKD patients with established/prolonged postprandial blood sugar. It was independently associated with mild CKD [odds ratio (OR) ¼ 5.213, 95% confidence interval (CI) ¼ 2.06-13.21, p ¼ 0.000], moderate CKD (OR ¼ 7.724, 95% CI ¼ 4.05-14.74, p ¼ 0.000) and severe CKD (OR ¼ 7.610, 95% CI ¼ 4.03-14.36, p ¼ 0.000). Conclusion: SBP and PP were the best predictors of prevalent nephropathy in this population, while DBP and FBS were found to be less effective. This may have implication for kidney disease risk stratification and protection.

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“…It is in correlation with the statement that lower BMI is a risk factor for osteoporosis [153], and also with the study of Singh et al reporting that disease stage and cancer related mortality significantly associated with increased BMI in breast cancer patients [157].…”

Section: Health and Health-related Behaviorsupporting

confidence: 84%

Health, health-related behavior and Quality of Life of middle- and old-aged women in Hungary

Maróti-Nagy

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Obesity augmented breast cancer risk: A potential risk factor for Indian women

Cited by 21 publications

References 41 publications

Hip circumference is associated with the risk of premenopausal ER−/PR− breast cancer

Hip circumference is associated with the risk of premenopausal ER−/PR− breast cancer

Prolonged elevated postprandial sugar augments severity in kidney disease: a North Indian hospital-based study

Health, health-related behavior and Quality of Life of middle- and old-aged women in Hungary

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