Obesity at Menopause: An Expanding Problem

Atapattu, P. M.

doi:10.4172/2573-4598.1000103

Cited by 21 publications

(14 citation statements)

References 119 publications

(148 reference statements)

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“…ese include menopausal symptoms [6], changes in anthropometric adiposity indices (AAI) [7], cardiovascular disease risk indicators (CVDRI) [8], muscle strength, and physical performance (PP) [9]. ese changes have the potential to progress to debilitating chronic diseases and functional disabilities [10][11][12][13][14] in later life.…”

Section: Introductionmentioning

confidence: 99%

Impact of Health-Promoting Lifestyle Education Intervention on Health-Promoting Behaviors and Health Status of Postmenopausal Women: A Quasi-Experimental Study from Sri Lanka

Rathnayake

Alwis

Lenora

et al. 2019

BioMed Research International

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Health promotion through lifestyle education is an important measure to enhance health status of postmenopausal women (PMW). This study evaluated the effectiveness of health-promoting lifestyle education intervention (HPLEI) on adhering to health-promoting behaviors (HPB) and enhancing the health status in a group of Sri Lankan PMW. A quasi-experimental study was conducted with randomly selected, sociodemographic status matched, 72 PMW from two geographically separated areas in Galle District, Sri Lanka, allocated as experimental (n = 37, 54.6 ± 4.5 years) and control (n = 35, 56.5 ± 3.4 years) groups. Education intervention focused on postmenopausal health management including lifestyle modifications was performed only for the experimental group during 8 weeks, and a health education package was provided. The control group was not given any planned education programme. Both groups were followed up for a 6-month period. HPB and menopausal symptoms severity were evaluated by validated Health Promoting Lifestyle Profile-II and Menopause Rating Scale, respectively. Anthropometric adiposity indices (AAIs) including weight, body mass index (BMI), waist (WC) and hip (HC) circumferences, and waist to hip ratio (WHR); cardiovascular disease risk indicators (CVDRI) including systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood sugar (FBS), total cholesterol and triglycerides, muscle strength; hand grip strength (HGS) and physical performance (PP); gait speed (GS) were measured. All parameters were evaluated before the intervention (baseline) and after follow-up of 6 months. All evaluated parameters were not different between experimental and control groups (p>0.05) at the baseline. In the follow-up evaluation, HPB (p<0.001), menopausal symptom scores (p<0.001), AAI (p<0.001), CVDRI (SBP, DBP, and FBS) (p<0.05) and HGS and GS (p<0.001) were significantly improved in the experimental group but not in the control group. Health education intervention focused on health-promoting lifestyle modifications is effective in improving the adherence to HPB and enhances the health status in PMW. This provides positive impact in lifestyle medicine.

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Section: Introductionmentioning

confidence: 99%

Impact of Health-Promoting Lifestyle Education Intervention on Health-Promoting Behaviors and Health Status of Postmenopausal Women: A Quasi-Experimental Study from Sri Lanka

Rathnayake

Alwis

Lenora

et al. 2019

BioMed Research International

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“…The menopausal women in our study were overweight (significantly higher BMI) as compared to reproductive-aged females, same as reported by Atapattu. [ 13 ] This all might be explained by a combination of advanced age, estrogen depletion, sedentary lifestyle, and higher comorbidities in the menopausal Group-2.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and menstrual status: Is menopause an independent risk factor for SARS Cov-2?

Mishra¹,

Sharma²,

Mishra³

et al. 2020

J Mid-life Health

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Background: COVID-19 has shown a definite association with gender, a predilection for males in terms of morbidity and mortality. The indirect evidence of the protective effect of estrogen has been shown by Channappanavar, in the animal model and Ding T. in a multihospital study from China, suggesting menopause as independent risk factor and estrogen is negatively correlated with severity. Objective: Study the clinical profile and outcomes in premenopausal and menopausal. Covid-19-infected women and analyzed the effect of menstrual status on the outcome. Materials and Methods: A retrospective cohort study conducted on 147 mild and moderate category COVID-19 females admitted between May and August 2020 using hospital records and telephonic follow-up. Two groups formed based on menstrual status: group-1 (premenopausal/estrogenic) and Group-2 (menopausal/hypoestrogenic). Hospital stay duration was considered as primary, while the category of disease on admission, clinical course, the requirement of oxygen, and mortality and residual symptoms were taken as a secondary outcome to compare the groups. Results: Overall Group-1 had significantly more of mild disease, while Group-2 had moderate cases (39 [76.5%] vs. 14 [14.6%] P < 0.01). Menopausal group has significantly more requirement of oxygen (32 [62.7%] vs. 20 [20.8%]), ventilation (14 [27.5%] vs. 1 [1%]) progression-to-severe disease (23.5% vs. 7.3%) and prolonged hospital stay ([14.1 ± 8.9 vs. 8.6 ± 3.9 days] P < 0.01). However, multivariate logistic regression failed to show a significant association between hospital stay and progression with menopause. Ferritin and residual symptoms found significantly higher in menopausal. Conclusions: No definite association was found between menopause and COVID-19 outcome with hospital stay duration or disease progression in our study.

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“…Such findings may indicate a protective effect of estrogens on urea metabolism which, after induction of ovarian failure, was lost in the sows of Group MEN. It is known that the absence of the protective effect of estrogen on the kidneys may contribute to increasing renal disease in postmenopausal women [ 83 ]. Hence, having in mind that nutritional management was the same for Groups CON and MEN, we can hypothesize that the renal disorders previously described for our swine model of obesity [ 28 ] may be intensified in sows with ovarian hormone stoppage.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Effects of Early Menopause on Adiposity, Fatty Acids Profile and Insulin Sensitivity of a Swine Model of Female Obesity

Heras-Molina

Pesantez-Pacheco

Vázquez-Gómez

et al. 2020

Biology

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Menopause strongly increases incidence and consequences of obesity and non-communicable diseases in women, with recent research suggesting a very early onset of changes in lipid accumulation, dyslipidemia, and insulin resistance. However, there is a lack of adequate preclinical models for its study. The present trial evaluated the usefulness of an alternative method to surgical ovariectomy, the administration of two doses of a GnRH analogue-protein conjugate (Vacsincel®), for inducing ovarian inactivity in sows used as preclinical models of obesity and menopause. All the sows treated with the compound developed ovarian stoppage after the second dose and, when exposed to obesogenic diets during the following three months, showed changes in the patterns of fat deposition, in the fatty acids profiles at the different tissues and in the plasma concentrations of fructosamine, urea, β-hydroxibutirate, and haptoglobin when compared to obese fed with the same diet but maintaining ovarian activity. Altogether, these results indicate that menopause early augments the deleterious effects induced by overfeeding and obesity on metabolic traits, paving the way for future research on physiopathology of these conditions and possible therapeutic targets using the swine model.

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Obesity at Menopause: An Expanding Problem

Cited by 21 publications

References 119 publications

Impact of Health-Promoting Lifestyle Education Intervention on Health-Promoting Behaviors and Health Status of Postmenopausal Women: A Quasi-Experimental Study from Sri Lanka

Impact of Health-Promoting Lifestyle Education Intervention on Health-Promoting Behaviors and Health Status of Postmenopausal Women: A Quasi-Experimental Study from Sri Lanka

COVID-19 and menstrual status: Is menopause an independent risk factor for SARS Cov-2?

Short-Term Effects of Early Menopause on Adiposity, Fatty Acids Profile and Insulin Sensitivity of a Swine Model of Female Obesity

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