Obesity-associated lymphedematous mucinosis and stasis mucinosis

Obesity‐associated lymphedematous mucinosis: dermoscopic‐histopathological findings and differential diagnosis

“…OALM as an entity was first described in 2006 by Tokuda et al 3 Its pathophysiology remains unknown, although it has been proposed that the accumulation of lymph in the dermal interstice leads to a decreased tissue oxygenation and stimulates the synthesis of mucopolysaccharides, with their consequent deposition. 1,4 It is characterized by the onset of soft consistency, skin-or erythematous-colored papules, with smooth surface, on the lower limbs, as in the presented case. Its mentioned histopathological findings, along with the absence of thyroid disease, can provide the diagnosis and allow its recognition among other forms of mucinoses.…”

“…Clinicopathological main differences among the most common mucinoses that settle in the pretibial area 1–4 . OALM: obesity‐associated lymphedematous mucinosis.…”

Case of hypothyroidism‐diagnostic unclassified cutaneous mucinosis showing a plaque on the flank region

“…Obesity-associated lymphedematous mucinosis has been reported to develop independently of thyroid dysfunction on the edematous legs based on obesity. 4 Our case was incompatible with the disease, because (i) the lesion was located on the abdomen, (ii) thyroid dysfunction was evident, and (iii) the BMI did not indicate severe obesity. A few cases of localized mucin deposition associated with hypothyroidism have been reported.…”

Thirty years of new entities in inflammatory dermatology and dermatopathology

“…These conditions, respectively, described in 2006 and 2010, involve obese patients or patients with venous insufficiency. 8 Clinically, patients present with papules and nodules progressing to plaques and arising in an erythematous and edematous basis on the legs, especially the shins. Histopathology indicates mucin deposition in the superficial portion of the dermis, an increase in small blood and/or lymphatic vessels with typical vertically running vessels.…”

“…These conditions, respectively, described in 2006 and 2010, involve obese patients or patients with venous insufficiency 8 . Clinically, patients present with papules and nodules progressing to plaques and arising in an erythematous and edematous basis on the legs, especially the shins.…”