Obesity as potential breast cancer risk factor for postmenopausal women

Mohanty, Swati Sucharita; Mohanty, P.

doi:10.1016/j.gendis.2019.09.006

Cited by 49 publications

(44 citation statements)

References 66 publications

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“…The increased risk in postmenopausal women is explained possibly due to increased level of circulating Estradiol by the conversion of androgens to estrone in the adipose tissue. [21] These results are similar to the study conducted by H M K Akalanka and colleagues in Srilanka in 2019. [23] They prospectively studied 230 pts (155 cases, 75 controls) in a span of 2 years and saw that higher BMI was associated with breast cancer patients as compared to controls.…”

Section: Discussion:-supporting

confidence: 90%

Lipid Profile and Its Significance in Breast Cancer

Arif¹,

ijar²,

Samad³

et al. 2020

IJAR

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Background: According to WHO, breast cancer is the most common cancer in the women worldwide, soearly diagnosis is the best way to reduce its morbidity and mortality. Among various risk factors, the relationship between serum lipid profile and breast cancer is still unclear. Therefore, this study was conducted to evaluate this relationship. Methodology: Prospective, descriptive observational study with a comparative study designconducted at Fauji Foundation Hospital, Rawalpindi between November 2018 to April 2019. Results: 140 patients were divided into two groups i.e. cases and controls. Both groups were equally sub divided based on menstrual status. Independent student t-test was applied for comparison between the groups. BMI was significantly higher in the study group as compared to control group (p=0.002). Serum TG and LDL levels were higher in breast cancer patients (p= 0.032 and p=0.07 respectively). Cholesterol level was not statistically different in any group (p= >0.05). Higher HDL levels were seen in pre-menopausal cases (p=0.004) but there was no statistical difference when studied across cases and control groups. Conclusion: As breast cancer is the most common tumor in females, so early diagnosis is the key to reduce its morbidity and mortality. In this study, higher BMI, TG and LDL levels were seen in breast cancer patients as compared to controls. So, it may be concluded that BMI and dyslipidemia have some role in the etiology of breast cancer.

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Section: Discussion:-supporting

confidence: 90%

Lipid Profile and Its Significance in Breast Cancer

Arif¹,

ijar²,

Samad³

et al. 2020

IJAR

View full text Add to dashboard Cite

show abstract

“…Long-term hormone administration to COP rats has been reported to promote development of mammary tumors that would otherwise undergo spontaneous regression [44]. Fat tissue is a source of estrogen, especially after senescence of ovarian function; thus, obesity and being overweight promote breast cancer development [45]. The difference in body weight among rat strains reported herein, which is concordant with that associated with mammary cancer susceptibility, is therefore a plausible factor that could explain the observed susceptibility.…”

Section: Plos Onesupporting

confidence: 63%

Development of mammary cancer in γ-irradiated F1 hybrids of susceptible Sprague-Dawley and resistant Copenhagen rats, with copy-number losses that pinpoint potential tumor suppressors

et al. 2021

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Copenhagen rats are highly resistant to mammary carcinogenesis, even after treatment with chemical carcinogens and hormones; most studies indicate that this is a dominant genetic trait. To test whether this trait is also dominant after radiation exposure, we characterized the susceptibility of irradiated Copenhagen rats to mammary carcinogenesis, as well as its inheritance, and identified tumor-suppressor genes that, when inactivated or mutated, may contribute to carcinogenesis. To this end, mammary cancer–susceptible Sprague-Dawley rats, resistant Copenhagen rats, and their F1 hybrids were irradiated with 4 Gy of γ-rays, and tumor development was monitored. Copy-number variations and allelic imbalances of genomic DNA were studied using microarrays and PCR analysis of polymorphic markers. Gene expression was assessed by quantitative PCR in normal tissues and induced mammary cancers of F1 rats. Irradiated Copenhagen rats exhibited a very low incidence of mammary cancer. Unexpectedly, this resistance trait did not show dominant inheritance in F1 rats; rather, they exhibited intermediate susceptibility levels (i.e., between those of their parent strains). The susceptibility of irradiated F1 rats to the development of benign mammary tumors (i.e., fibroadenoma and adenoma) was also intermediate. Copy-number losses were frequently observed in chromosome regions 1q52–54 (24%), 2q12–15 (33%), and 3q31–42 (24%), as were focal (38%) and whole (29%) losses of chromosome 5. Some of these chromosomal regions exhibited allelic imbalances. Many cancer-related genes within these regions were downregulated in mammary tumors as compared with normal mammary tissue. Some of the chromosomal losses identified have not been reported previously in chemically induced models, implying a novel mechanism inherent to the irradiated model. Based on these findings, Sprague-Dawley × Copenhagen F1 rats offer a useful model for exploring genes responsible for radiation-induced mammary cancer, which apparently are mainly located in specific regions of chromosomes 1, 2, 3 and 5.

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“…Breast carcinoma is the second highest prevailing cancer globally after lung with 2.09 million cases in 2018, and it is also the second highest cancer prevailing in 2018 with 2 088 849 new cases. In India, there were recorded 162 468 new cases and 87 090 deaths due to breast cancer during 2018 1‐3 . A gargantuan portion of breast cancers is comparatively diagnosed at an advanced level due to truancy of a better screening program, insufficient and improper medical care owing to the inadequacy of exquisite foundation, occasionally expertise and primarily due to lack of pecuniary funds 4 .…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of fine needle aspiration cytology (FNAC) in detecting breast malignancy with the clinical location of lumps

Mohanty

2020

Breast J

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The objectives were to study the diagnostic accuracy of FNAC in detecting malignancy in palpable breast lumps and know the relationship of the tumor with the quadrants of the breast (clinical location of breast lumps). FNAC slides of 420 female patients with a palpable breast lump were evaluated. Relationship of tumor with the quadrants of the breast was as follows: upper outer 57.14%, upper inner 13.33%, lower outer 11.9%, lower inner 6.67%, and central quadrant 10.95%. The sensitivity, specificity, disease prevalence, positive predictive value, negative predictive value, and diagnostic accuracy of FNAC in this study were calculated as 93.42%, 100%, 57.86%, 100%, 91.71%, and 96.19%, respectively.

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Obesity as potential breast cancer risk factor for postmenopausal women

Cited by 49 publications

References 66 publications

Lipid Profile and Its Significance in Breast Cancer

Lipid Profile and Its Significance in Breast Cancer

Development of mammary cancer in γ-irradiated F1 hybrids of susceptible Sprague-Dawley and resistant Copenhagen rats, with copy-number losses that pinpoint potential tumor suppressors

Diagnostic accuracy of fine needle aspiration cytology (FNAC) in detecting breast malignancy with the clinical location of lumps

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