Obesity as a risk factor for GERD in Japan

Sakaguchi, Masahiro; Oka, Hiroshi; Hashimoto, Takashi; Asakuma, Yutaka; Takao, Miyuki; Gon, Goki; Yamamoto, Makoto; Tsuji, Yoshihisa; Yamamoto, Norio; Shimada, M.; Lee, Kyowon; Ashida, Kiyoshi

doi:10.1007/s00535-007-2128-7

Cited by 53 publications

(51 citation statements)

References 25 publications

(24 reference statements)

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“…Lifestyle factors, such as eating foods with high components of fat or in large portions, alcohol intake, smoking, obesity, and metabolic syndrome, have also been reported to be related to a high prevalence of reflux esophagitis and GERD symptoms (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). In addition, the factors shown to induce and/or worsen GERD have also been demonstrated to be associated with periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…An increased gastroesophageal pressure gradient and hiatal hernia development have been reported to be induced by a high intra-abdominal pressure due to abdominal fat accumulation (3)(4)(5)(6)(7), while obesity and a high body mass index (BMI) have repeatedly been demonstrated to be associated with the high prevalence of reflux esophagitis and GERD symptoms (8)(9)(10)(11)(12)(13)(14)(15). In addition, metabolic syndrome, diagnosed by the presence of visceral fat accumulation, dyslipidemia, hypertension, and hyperglycemia, has been demonstrated to correlate with the occurrence of GERD (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

“…Signs and symptoms include swollen gums, deepening of gingival crevices leading to the formation of periodontal pockets, bleeding on brushing, increased spacing between teeth, and loose teeth. Recent studies have indicated that periodontitis is closely correlated with systemic disorders, such as obesity, metabolic syndrome and cardiovascular diseases (19,20), which have also been demonstrated to have a positive relationship with GERD occurrence (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). In addi-tion, periodontitis may induce or worsen GERD, since saliva secretion, which is influenced by oral hygiene including the periodontal status, has been demonstrated to be associated with GERD (21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

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A Study on the Relationship between Reflux Esophagitis and Periodontitis

et al. 2016

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Objective Metabolic syndrome and dental erosion have been demonstrated to correlate with gastroesophageal acid reflux disease (GERD), while periodontitis has been reported to have a positive relationship with metabolic syndrome. However, no correlation between periodontitis and GERD has yet been reported. We therefore investigated the relationship between periodontitis and GERD. Methods The subjects consisted of 280 individuals who visited the Health Center for a detailed medical checkup examination. Each underwent upper endoscopy and periodontitis examinations, with the latter performed by measuring the concentrations of lactate dehydrogenase and hemoglobin in saliva. The subjects were divided into those with positive and negative periodontitis findings, and the prevalence rates of endoscopically proven reflux esophagitis, dyslipidemia, hypertension, and hyperglycemia were compared. Results The number of subjects positive for periodontitis was 93, while 187 had negative findings. The prevalence of reflux esophagitis was not different between the positive and negative groups (8.6% vs. 8.0%). In addition, a multiple logistic regression analysis did not identify a positive relationship between the presence of periodontitis and reflux esophagitis. On the other hand, dyslipidemia and hypertension were more frequently observed in the subjects that were positive for periodontitis. Conclusion We did not find an association between periodontitis and reflux esophagitis in the present study. On the other hand, the presence of periodontitis was found to correlate with hypertension and dyslipidemia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Study on the Relationship between Reflux Esophagitis and Periodontitis

et al. 2016

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“…[3][4][5][6] There are many opinions on the relationship between obesity and GERD; for example, obesity is a risk factor for GERD. 7 However, we found no relationship between body mass index and esophageal dysfunction in our patients (unpublished data). The duration of diabetes and autonomic neuropathy may infl uence the pathophysiology of esophageal dysfunction in patients with diabetes.…”

Section: Authors' Replymentioning

confidence: 48%

Authors’ reply

Kinekawa

Masaki

Kubo³

et al. 2009

J Gastroenterol

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“…In the study of Sakaguchi et al (32), weight gain was defined as gaining 2 kilos in the last 2 months and losing weight was defined as losing 2 kilos in the last 2 months. According to this definition, a higher prevalence of GERD was determined in those who gained weight in the end of 2 months in comparison to those with no weight change or who lost weight in the end of 2 months (p<0.005).…”

Section: Does a Decrease Occur In The Severity And Development Of Gasmentioning

confidence: 99%