Obesity and Vitamin D Deficiency

Stokić, Edita; Kupusinac, Aleksandar; Tomic-Naglic, Dragana; Zavišić, Branka Kovačev; Mitrović, Milena; Smiljenić, Dragana; Šoškić, Sanja; Isenović, Esma R.

doi:10.1177/0003319714528569

Cited by 35 publications

(21 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although BMI, WC and FAT trunk % had a significant and inverse correlation with vitamin D levels in all studied subjects, only BMI was significantly associated with 25(OH)D levels in obese patients. This finding is consistent with previous studies suggesting that an increase in BMI may decrease vitamin D levels in obese patients, and different mechanisms have been proposed to explain the relationship between obesity and low vitamin D status [18, 19, 21]. …”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study

Ilinčić¹,

Stokić²,

Stosić³

et al. 2017

aoms

Self Cite

View full text Add to dashboard Cite

IntroductionObesity and inadequate vitamin D status are associated with endothelial dysfunction and cardiovascular disease. We evaluated the associations between vitamin D status (i.e. serum levels of 25-hydroxyvitamin D (25(OH)D)), biomarkers of endothelial dysfunction (i.e. serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble E-selectin (sE-selectin)), inflammatory markers (i.e. high-sensitivity C-reactive protein (hsCRP) and fibrinogen) and cardiometabolic risk factors.Material and methodsFifty obese (body mass index (BMI) ≥ 30 kg/m2) non-diabetic adults (mean age: 36.2 ±5.4 years) without pre-existing cardiovascular abnormalities and 25 clinically healthy, normal weight and age-matched individuals were included. Anthropometric parameters, markers of glucose and lipid metabolism, and serum levels of inflammatory and endothelial dysfunction biomarkers were assessed in all subjects.ResultsThe mean serum 25(OH)D level was significantly lower in the obese group than in controls (33.5 ±15.2 vs. 60.1 ±23.1 nmol/l; p < 0.001). In the obese group, sE-selectin (36.4 (32.1–47.2) vs. 32.4 (24.6–35.5) ng/ml, p < 0.05) and hsCRP (6.0 ±3.4 vs. 3.5 ±1.0 mg/l, p < 0.05) were significantly higher in individuals with lower than median vitamin D levels (i.e. 31 nmol/l) compared with those with higher vitamin D levels. In multivariable linear regression analysis, hsCRP (β = –0.43; p < 0.001) and sE-selectin (β = –0.30; p = 0.03) were independently and significantly associated with serum 25(OH)D levels in the obese group.ConclusionsVitamin D levels may be related to increased levels of biomarkers of endothelial dysfunction and inflammation in obese non-diabetic individuals.

show abstract

Section: Discussionsupporting

confidence: 93%

“…Moreover, cross-sectional studies have reported inverse associations between low serum 25(OH)D levels and cardiometabolic risk factors (e.g. abdominal obesity, hypertension, hyperglycemia) [21, 22], which may also promote the development and progression of endothelial dysfunction in obese patients.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study

Ilinčić¹,

Stokić²,

Stosić³

et al. 2017

aoms

Self Cite

View full text Add to dashboard Cite

show abstract

“…Notwithstanding the inverse association between BMI and fat mass[114], higher plasma 25OHD has been associated with lower amounts of VAT and with reduced omental adipocyte size[115-119], suggesting a link between vitamin D status and fat distribution. This is further substantiated by reports of the regulatory effects of vitamin D on adipose tissue and lipid storage and by the fact that vitamin D receptor (VDR) is expressed in adipocytes both in animals models and in humans.…”

Section: Vitamin D Adiposity and Nafldmentioning

confidence: 99%

Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease

Cimini

Barchetta

Carotti

et al. 2017

WJG

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood. Over the years many studies have proposed various pathophysiological hypotheses, among which the currently most widely accepted is the “multiple parallel hits” theory. According to this model, lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury, inflammation and fibrosis. Among these factors, adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role. Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue, and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD. Furthermore, given the strong association between these conditions, current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD. The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction, and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity, together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD.

show abstract

“…Currently, there is extensive research on the function of vitamin D in chronic disease like obesity [10-12]. Prospective studies have stated that low 25(OH) 2 D plasma levels may define the prevalence of obesity [7].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults

Sajjadi¹,

Mirzaei

Khorraminezhad

et al. 2017

Ann Nutr Metab

View full text Add to dashboard Cite

Background: Resting metabolic rate (RMR) used to prognosticate and measure the amount of energy required. Vitamin D is known as a new predictor of RMR. The aim of this study is to investigate the relationship between vitamin D effects on RMR in connection with the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) gene expression. Methods: We enrolled 298 overweight and obese adults in this cross-sectional study. Body mass index (BMI), fat mass, fat-free mass, insulin level, visceral fat, and vitamin D status were assessed. RMR was measured by means of indirect calorimetry. The real-time polymerase chain reaction using specific primer pairs for VDR and PGC-1α was performed. Results: There were significant differences in terms of fat free mass, fat percentage, insulin levels, RMR/kg body weight, and RMR/BMI, VDR, and PGC-1α among participants were categorized based on the vitamin D status. But after using general linear model for adjusting, all significant results missed their effectiveness except RMR/kg body weight and VDR. Linear regression analysis used to show the mediatory role of VDR and PGC-1α on the RMR/kg body weight and vitamin D status relationship. Our results showed that VDR had a mediatory effect on the relationship between RMR/kg body weight and vitamin D status (β = 0.38, 95% CI –0.48 to 1.60; β = –1.24, 95% CI –5.36 to 1.70). However, PGC-1α did not affect the relationship between RMR/kg body weight and vitamin D status (β = 0.50, 95% CI = –0.02 to 3.42; β = 0.59, 95% CI 0.14–3.90). Conclusion: Our study showed the mediatory effect of VDR gene expression in the association of 25(OH)₂D plasma levels and resting metabolic rate among obese individuals.

show abstract

Obesity and Vitamin D Deficiency

Cited by 35 publications

References 47 publications

Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study

Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study

Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease

Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults

Contact Info

Product

Resources

About