Obesity and screening PSA levels among men undergoing an annual physical exam

Rundle, Andrew; Neugut, Alfred I.

doi:10.1002/pros.20704

Cited by 55 publications

(60 citation statements)

References 25 publications

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“…A mathematical model was established for the calculation of a serum PSA level in an obese man that corresponds to a PSA of 4.0 ng/mL in a nonobese man (5). The geometric means of height, weight, and HCT were obtained for the nonobese and obese group, respectively, to calculate the PV of each group (PV Nonobese and PV Obese ).…”

Section: Statistical Analysesmentioning

confidence: 99%

“…The geometric means of height, weight, and HCT were obtained for the nonobese and obese group, respectively, to calculate the PV of each group (PV Nonobese and PV Obese ). As PSA mass was assumed to be consistent according to BMI group in healthy cohorts (3,5), an equation can be extrapolated: the cutoff value of PSA concentration predicted for an obese man in this cohort ¼ 4.0 ng/mL Â PV Nonobese /PV Obese . The HCT-based and BSA-based PVs were put into the model, respectively.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Recent studies (3)(4)(5) showed that although PSA concentration decreased significantly with the increase of body mass index (BMI), the estimated PSA mass did not, indicating that the lower PSA concentration observed in obese men could be merely because of the fact that men with greater BMI also tended to have larger plasma volume (PV). In these studies, estimated PV and PSA mass were based on a body surface area (BSA) equation.…”

Section: Introductionmentioning

confidence: 99%

“…The evidence of hemodilution effect among obese men and the implications for PSA screening; 2. The agreement between the estimates by using the HCT-based (7,8) and the BSA-based (3)(4)(5) equations.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Serum Prostate-Specific Antigen Concentration and Hemodilution among Chinese Middle-Aged Obese Men: A Hematocrit-Based Equation for Plasma Volume Estimation Is Induced

Li¹,

Zhang²,

Lu³

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: A hematocrit (HCT)-based and a body surface area (BSA)-based equations were applied for plasma volume (PV) estimation, respectively, to confirm and quantify the hemodilution effect in prostatespecific antigen (PSA) screening among obese men. The agreement between the equations was additionally investigated.Methods: A total of 1,444 men were retrospectively collected, with ages 40 to 65 years, PSA 0 to 4 ng/mL, and no prostate cancer. PSA mass was calculated as PSA concentration multiplied by PV. Multivariable linear regression models, theoretical models, and the Bland-Altman method were used.Results: PSA concentration significantly decreased with increasing body mass index (BMI; b ¼ À0.011, P < 0.001); however, PSA mass estimated by HCT-(b ¼ 0.004, P ¼ 0.132) and BSA (b ¼ À0.003, P ¼ 0.094)-based equations remained consistent. A screening PSA of 4.0 ng/mL in nonobese men was found to be corresponding to 3.32 and 3.68 ng/mL in obese men extrapolated by PV on the basis of HCT and BSA, respectively. Moreover, the mean (95% confidence interval) difference of PV between the two equations was 0.33 (À0.06 to 0.73) L.Conclusions: The inverse relationship between PSA concentration and BMI might be explained by a hemodilution effect among obese men. There is significant variation in PV calculated by the two equations.Impact: A value between 3.32 and 3.68 ng/mL might be recommended for PSA screening in middle-aged obese Asian men. Cancer Epidemiol Biomarkers Prev; 21(10);

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Section: Statistical Analysesmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum Prostate-Specific Antigen Concentration and Hemodilution among Chinese Middle-Aged Obese Men: A Hematocrit-Based Equation for Plasma Volume Estimation Is Induced

Li¹,

Zhang²,

Lu³

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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show abstract

“…[6][7][8][9] There are several possible explanations why PSA may be lower among men with T2DM than among men without T2DM, including greater obesity and more frequent use of medications used to treat dyslipidemia and hypertension. Men with higher BMI have lower mean total PSA than men with lower BMIs, [10][11][12] possibly due to hemodilution from increased plasma volume in larger men, 13 or lower androgen levels that characterize more obese and insulin resistant adult males. 14 PSA has been reported to decrease in response to statins, which are more commonly used among persons with T2DM.…”

Section: Introductionmentioning

confidence: 99%

78 Poor Glycemic Control Is Associated With Reduced Prostate-Specific Antigen Concentrations in Men With Type 1 Diabetes

Sarma

Hotaling

Cleary³

et al. 2012

Journal of Urology

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PURPOSE-Previous studies have demonstrated lower prostate-specific antigen (PSA) concentrations in men with type 2 diabetes (T2DM), paralleling the reported lower prevalence of prostate cancer among diabetic men. Data on PSA in men with type 1 diabetes (T1DM), in whom insulin and obesity profiles differ from those in T2DM, are lacking. The objective of this study was to examine the relationship between long-term glycemic control and PSA in men with T1DM. MATERIALS & METHODS-TotalPSA was measured at one time in 639 men in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, the observational follow up of participants in the Diabetes Control and Complications Trial (DCCT). The relationship between DCCT/EDIC weighted mean HbA1c and log PSA was assessed using linear regression modeling after adjusting for age, body mass index (BMI), total testosterone, statin and thiazide medication use, diabetes duration, and DCCT randomization arm and cohort. RESULTS-The subjects had a median age of 52 years, BMI of 28.4 kg/m 2 and DCCT/EDIC time weighted HbA1c of 7.9%. Total median (interquartile range) for PSA levels was 0.64 (0.43, 1.05). PSA levels increased significantly with age (p<0.0001) and with lower time weighted HbA1c (p<0.0001). Each 10% increase in HbA1c was accompanied by an 11% reduction in PSA (p=0.0001). CONCLUSIONS-PSA levels decrease as HbA1c increases in men with T1DM. This relationship is independent of age, BMI, androgen levels, medication use and measures of diabetes severity, which suggest that factors related to glycemia may be directly affecting PSA levels. HHS Public Access

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Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear development

Urness

Wang

et al. 2007

Developmental Dynamics

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The levels of fibroblast growth factor (FGF) signaling play important roles in coordinating development of the mouse inner, middle, and outer ears. Extracellular signal-regulated kinases (ERKs) are among the effectors that transduce the FGF signal to the nucleus and other cellular compartments. Attenuation of ERK activity by dephosphorylation is necessary to modulate the magnitude and duration of the FGF signal. Recently, we showed that inactivation of the ERK phosphatase, dual specificity phosphatase 6 (DUSP6), causes partially penetrant postnatal lethality, hearing loss and skeletal malformations. To determine whether other Dusps may function redundantly with Dusp6 during otic development, we surveyed the expression domains of the three ERK-specific DUSP transcripts, Dusp6, Dusp7, and Dusp9, in the embryonic mouse ear. We show that each is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development.

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Obesity and screening PSA levels among men undergoing an annual physical exam

Abstract: Across the study population, increased BMI was significantly inversely associated with lower PSA. Based on a theoretical model in which increased plasma volume in the obese dilutes PSA levels we propose new cut-points for a positive screening test.

Cited by 55 publications

References 25 publications

Serum Prostate-Specific Antigen Concentration and Hemodilution among Chinese Middle-Aged Obese Men: A Hematocrit-Based Equation for Plasma Volume Estimation Is Induced

Serum Prostate-Specific Antigen Concentration and Hemodilution among Chinese Middle-Aged Obese Men: A Hematocrit-Based Equation for Plasma Volume Estimation Is Induced

78 Poor Glycemic Control Is Associated With Reduced Prostate-Specific Antigen Concentrations in Men With Type 1 Diabetes

Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear development

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