Obesity and risk of hearing loss: A prospective cohort study

Hu, Huanhuan; Tomita, Kentaro; Kuwahara, Keisuke; Yamamoto, Makoto; Uehara, Akihiko; Kochi, Takeshi; Eguchi, M.; Okazaki, Hiroko; Hori, Akihiro; Sasaki, Nozomu; Ogasawara, Takayuki; Honda, Takeshi; Yamamoto, S.; Nakagawa, Tohru; Miyamoto, Toshiaki; Imai, Toshio; Nishihara, Akiko; Nagahama, Satsue; Murakami, Taizo; Shimizu, Makiko; Akter, Shamima; Kashino, Ikuko; Yamaguchi, Miwa; Kabe, Isamu; Mizoue, Tetsuya; Sone, Toshio; Dohi, Seitaro

doi:10.1016/j.clnu.2019.03.020

Cited by 48 publications

(66 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Eckert et al (2013) have used an estimate of SVD to show that age-related changes in low frequency hearing was related to a global decline in vascular health, and Tabuchi (2014) has described the occurrence of auditory dysfunction in patients with cerebrovascular disease. Hearing deficit may also accompany dementia risk factors such as obesity ( Hu et al, 2020 ), sedentary behavior ( Loprinzi, 2013 ), and sleep apnea ( Chopra et al, 2016 ). Hearing loss therefore may be a consequence of inflammation, and evidence that inflammation-induced vasospasm is involved in the pathogenesis of acquired sensorineural hearing loss was eloquently presented recently by Eisenhut (2019) .…”

Section: Discussionmentioning

confidence: 99%

A Proposed Hypothesis on Dementia: Inflammation, Small Vessel Disease, and Hypoperfusion Is the Sequence That Links All Harmful Lifestyles to Cognitive Impairment

Hakim

2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

There is growing consensus that certain lifestyles can contribute to cognitive impairment and dementia, but the physiological steps that link a harmful lifestyle to its negative impact are not always evident. It is also unclear whether all lifestyles that contribute to dementia do so through the same intermediary steps. This article will focus on three lifestyles known to be risk factors for dementia, namely obesity, sedentary behavior, and insufficient sleep, and offer a unifying hypothesis proposing that lifestyles that negatively impact cognition do so through the same sequence of events: inflammation, small vessel disease, decline in cerebral perfusion, and brain atrophy. The hypothesis will then be tested in a recently identified risk factor for dementia, namely hearing deficit. If further studies confirm this sequence of events leading to dementia, a significant change in our approach to this debilitating and costly condition may be necessary, possible, and beneficial.

show abstract

Section: Discussionmentioning

confidence: 99%

A Proposed Hypothesis on Dementia: Inflammation, Small Vessel Disease, and Hypoperfusion Is the Sequence That Links All Harmful Lifestyles to Cognitive Impairment

Hakim

2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Central obesity, increased waist circumference, and increased hearing threshold after BMI correction of the content of visceral adipose tissue were found to be related [ 20 ]. Obesity, as determined by BMI, has been associated with an increased risk of hearing loss [ 26 ]. Moreover, abdominal lipid-related factors were reported to be associated with hearing loss at specific frequency bands [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…For example, one study found that WHR may be a surrogate marker for predicting the risk of hearing loss, [ 18 ] whereas another study suggested that FRAs were associated with hearing loss at specific frequencies, as determined by sex and the presence of diabetes, and that visceral adipose tissue (VAT) is particularly important role for hearing [ 25 ]. Two studies found relationships between BMI and hearing loss, with one finding that underweight and severe obesity were associated with an increased prevalence of hearing loss in a Korean population, and the other reporting that overweight was associated with an increased risk of hearing loss in a Japanese population [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Metabolic Syndrome with Sensorineural Hearing Loss

Rim

Kim

Park

et al. 2021

JCM

View full text Add to dashboard Cite

The prevalence of sensorineural hearing loss has increased along with increases in life expectancy and exposure to noisy environments. Metabolic syndrome (MetS) is a cluster of co-occurring conditions that increase the risk of heart disease, stroke and type 2 diabetes, along with other conditions that affect the blood vessels. Components of MetS include insulin resistance, body weight, lipid concentration, blood pressure, and blood glucose concentration, as well as other features of insulin resistance such as microalbuminuria. MetS has become a major public health problem affecting 20–30% of the global population. This study utilized health examination to investigate whether metabolic syndrome was related to hearing loss. Methods: A total of 94,223 people who underwent health check-ups, including hearing tests, from January 2010 to December 2020 were evaluated. Subjects were divided into two groups, with and without metabolic syndrome. In addition, Scopus, Embase, PubMed, and Cochrane libraries were systematically searched, using keywords such as “hearing loss” and “metabolic syndrome”, for studies that evaluated the relationship between the two. Results: Of the 94,223 subjects, 11,414 (12.1%) had metabolic syndrome and 82,809 did not. The mean ages of subjects in the two groups were 46.1 and 43.9 years, respectively. A comparison of hearing thresholds by age in subjects with and without metabolic syndrome showed that the average pure tone hearing thresholds were significantly higher in subjects with metabolic syndrome than in subjects without it in all age groups. (p < 0.001) Rates of hearing loss in subjects with 0, 1, 2, 3, 4, and 5 of the components of metabolic syndrome were 7.9%, 12.1%, 13.8%, 13.8%, 15.5% and 16.3%, respectively, indicating a significant association between the number of components of metabolic syndrome and the rate of hearing loss (p < 0.0001). The odds ratio of hearing loss was significantly higher in subjects with four components of metabolic syndrome: waist circumference, blood pressure, and triglyceride and fasting blood sugar concentrations (p < 0.0001). (4) Conclusions: The number of components of the metabolic syndrome is positively correlated with the rate of sensorineural hearing loss.

show abstract

“…Notch signaling is crucial for cell-cell communication and development, and it has been found important for metabolism that improves glucose tolerance, insulin sensitivity and ameliorates obesity and atherosclerosis [59]. There are also reports of changes in auditory [60][61][62], sight [63,64] and pharyngeal function [65,66] that relate to high BMI or obesity. The top significant probes are all inferred as differentially expressed in response to BMI but not as causing changes in BMI.…”

Section: Discussionmentioning

confidence: 99%

Differential Long Noncoding RNA Profiling of BMI in Twins

Baumbach

Larsen

et al. 2020

Epigenomics

View full text Add to dashboard Cite

Aim: Many efforts have been deployed to identify genetic variants associated with BMI. Alternatively, we explore epigenetic contribution to BMI variation by focusing on long noncoding RNAs (lncRNAs) which represents a key layer of epigenetic control. Materials & methods: We analyzed lncRNA expression in whole blood of 229 monozygotic twin pairs in association with BMI using generalized estimating equations. Results & conclusion: Six lncRNA probes were identified as significant (false discovery rate <0.05), with BMI showing causal effects on the expression of the significant lncRNAs. Functional annotation of differential profiles identified Gene ontology biological processes including kidney development, regulations of lipid biosynthetic process, circadian rhythm, notch signaling, etc. Whole blood lncRNAs are significantly expressed in response to BMI variation.

show abstract

Obesity and risk of hearing loss: A prospective cohort study

Cited by 48 publications

References 29 publications

A Proposed Hypothesis on Dementia: Inflammation, Small Vessel Disease, and Hypoperfusion Is the Sequence That Links All Harmful Lifestyles to Cognitive Impairment

A Proposed Hypothesis on Dementia: Inflammation, Small Vessel Disease, and Hypoperfusion Is the Sequence That Links All Harmful Lifestyles to Cognitive Impairment

Association of Metabolic Syndrome with Sensorineural Hearing Loss

Differential Long Noncoding RNA Profiling of BMI in Twins

Contact Info

Product

Resources

About