Obesity and risk for incident rosacea in US women

Li, Suyun; Cho, Eunyoung; Drucker, Aaron M.; Qureshi, Abrar A.; Li, Wenqing

doi:10.1016/j.jaad.2017.08.032

Cited by 35 publications

(36 citation statements)

References 32 publications

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“…Hitherto conducted studies confirm a significant bi‐directional association in the occurrence of IBD and rosacea . Other examples of concomitant gastrointestinal conditions are coeliac disease, gastrointestinal flora alterations and metabolic conditions such as obesity and insulin resistance . Nam et al .…”

Section: Methodsmentioning

confidence: 94%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential for the establishment of organism immunity. The human microbiota ecosystem can be divided into several compartments, out of which intestinal flora strongly affects our health and plays a crucial role in the pathophysiology of many diseases. The gastrointestinal tract, being a major guardian of the immune system, maintains the homeostasis with the commensal microorganisms by tolerating the typical flora antigens. The dysbiosis may trigger an inflammatory response followed by tissue damage or autoimmune processes. The gut microbiome alterations are linked to the pathogenesis of the allergic, cardiovascular, gastrointestinal, metabolic, neurodevelopmental, psychiatric and neurodegenerative diseases and cancer. Moreover, there is increasing evidence connecting the skin condition with the gastrointestinal microbiome, which has been described as the skin–gut axis. The aim of this study was to review the literature regarding the role of the gut microbiome alterations in the pathogenesis of selected allergic and inflammatory skin diseases.

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Section: Methodsmentioning

confidence: 94%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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“…In a recent cohort study, obesity was implicated as a risk factor of rosacea. The association between rosacea and BMI was significant, and weight gain with age and central obesity increased the risk of rosacea . Likewise, a twin study exhibited a positive correlation between rosacea and BMI, ultraviolet radiation exposure and cardiovascular morbidity .…”

Section: Discussionmentioning

confidence: 88%

“…Likewise, a twin study exhibited a positive correlation between rosacea and BMI, ultraviolet radiation exposure and cardiovascular morbidity . Although there were conflicting results among clinical studies, obesity per se may be relevant to rosacea on the basis of a common pathogenesis involving chronic inflammation . For instance, IL‐6 and TNF‐α are pro‐inflammatory cytokines that are upregulated in rosacea and also involved in obesity‐induced inflammation .…”

Section: Discussionmentioning

confidence: 99%

“…Recent investigation of rosacea pathogenesis has shown that an assortment of diverse comorbidities are linked to rosacea. Notably, dyslipidemia, hypertension, obesity and insulin resistance, which are components of metabolic syndrome (MetS), tend to be accompanied by cutaneous blemishes . Presumably, the association between MetS and rosacea is driven by a common mechanism through activation of pro‐inflammatory cytokines and progressive vascular dysfunction .…”

Section: Introductionmentioning

confidence: 99%

“…Notably, dyslipidemia, hypertension, obesity and insulin resistance, which are components of metabolic syndrome (MetS), tend to be accompanied by cutaneous blemishes . Presumably, the association between MetS and rosacea is driven by a common mechanism through activation of pro‐inflammatory cytokines and progressive vascular dysfunction . For instance, LL‐37, an active form of cathelicidin, plays an antimicrobial role and simultaneously enables immune cells and keratinocytes to induce the inflammatory response by enhancing chemokine and cytokine release, thus contributing to obesity as well as rosacea .…”

Section: Introductionmentioning

confidence: 99%

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Association between rosacea severity and relative muscle mass: A cross‐sectional study

Nam

Yang

Park³

et al. 2018

The Journal of Dermatology

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Rosacea is thought to be associated with factors involved in metabolic syndrome (MetS). Muscle mass has a beneficial role in preventing MetS, but its link to rosacea remains unknown. We sought to investigate the association between rosacea severity and relative skeletal muscle mass. A cross‐sectional study was conducted on subjects who attended a skin check‐up program at the Kangbuk Samsung Hospital Health Screening Center between 2014 and 2016. Polarized light photographs of the face were taken and evaluated by two dermatologists. Skeletal muscle mass index (SMI, [%] = total skeletal muscle mass [kg] / bodyweight [kg] × 100) was estimated using a bioelectrical impedance analyzer. A logistic regression model was used to evaluate an association between SMI and rosacea. Of 110 rosacea subjects who were finally enrolled, 17 (15.5%) and 93 (84.5%) were classified as having papulopustular and erythematotelangiectatic rosacea, respectively. Categories of SMI comprised the following tertiles: 22.86–38.40%, 38.41–43.44% and 43.45–80.65%. In severity, compared with mild rosacea (75.5%), moderate rosacea (24.5%) incrementally increased as SMI decreased (Ptrend < 0.01). Severe rosacea was not observed. After adjustment for age and sex, odds ratios (95% confidence intervals) for moderate rosacea comparing SMI tertiles 1 and 2 to the highest tertile (reference) were 5.66 (1.22–26.20) and 4.43 (1.12–17.55), respectively (Ptrend = 0.03). This association was present in women with marginal significance (Ptrend = 0.06), but not in men. Relative muscle mass is negatively associated with an increased risk of more severe rosacea, suggesting that skeletal muscle can have a protective effect on rosacea exacerbation.

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Association of Caffeine Intake and Caffeinated Coffee Consumption With Risk of Incident Rosacea in Women

Chen

Drucker

et al. 2018

JAMA Dermatol

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IMPORTANCE Caffeine is known to decrease vasodilation and have immunosuppressant effects, which may potentially decrease the risk of rosacea. However, the heat from coffee may be a trigger for rosacea flares. The relationship between the risk of rosacea and caffeine intake, including coffee consumption, is poorly understood. OBJECTIVE To determine the association between the risk of incident rosacea and caffeine intake, including coffee consumption. DESIGN, SETTING, AND PARTICIPANTS This cohort study included 82 737 women in the Nurses' Health Study II (NHS II), a prospective cohort established in 1989, with follow-up conducted biennially between 1991 and 2005. All analysis took place between June 2017 and June 2018. EXPOSURES Data on coffee, tea, soda, and chocolate consumption were collected every 4 years during follow-up. MAIN OUTCOMES AND MEASURES Information on history of clinician-diagnosed rosacea and year of diagnosis was collected in 2005. RESULTS A total of 82 737 women responded to the question regarding a diagnosis of rosacea in 2005 in NHS II and were included in the final analysis (mean [SD] age at study entry, 50.5 [4.6] years). During 1 120 051 person-years of follow-up, we identified 4945 incident cases of rosacea. After adjustment for other risk factors, we found an inverse association between increased caffeine intake and risk of rosacea (hazard ratio for the highest quintile of caffeine intake vs the lowest, 0.76; 95% CI, 0.69-0.84; P < .001 for trend). A significant inverse association with risk of rosacea was also observed for caffeinated coffee consumption (HR, 0.77 for those who consumed Ն4 servings/d vs those who consumed <1/mo; 95% CI, 0.69-0.87; P < .001 for trend), but not for decaffeinated coffee (HR, 0.80; 95% CI, 0.56-1.14; P = .39 for trend). Further analyses found that increased caffeine intake from foods other than coffee (tea, soda, and chocolate) was not significantly associated with decreased risk of rosacea. CONCLUSIONS AND RELEVANCE Increased caffeine intake from coffee was inversely associated with the risk of incident rosacea. Our findings do not support limiting caffeine intake as a means to prevent rosacea. Further studies are required to explain the mechanisms of action of these associations, to replicate our findings in other populations, and to explore the relationship of caffeine with different rosacea subtypes.

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Obesity and risk for incident rosacea in US women

Cited by 35 publications

References 32 publications

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Association between rosacea severity and relative muscle mass: A cross‐sectional study

Association of Caffeine Intake and Caffeinated Coffee Consumption With Risk of Incident Rosacea in Women

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