Obesity and Related Disorders

Wang, Yanwen

doi:10.1002/9781444323351.ch18

Cited by 2 publications

(3 citation statements)

References 187 publications

(201 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum total cholesterol (T-C), high-density lipoprotein cholesterol (HDL-C,) and triacylglycerols (TAG) were analyzed using the enzymatic methods on a pointe-180 chemistry analyzer (Point Scientific Inc., Canton, MI), with 2.2%, 1.3%, and 6.5% intra-assay coefficients of variation, respectively. Non-HDL cholesterol (nonHDL-C) was calculated by subtracting HDL-C from T-C. 4 Serum free fatty acids (FFA) were measured using a commercial kit following the manufacturer's instructions (BioVision, Mountain View, CA), with 2% and 0.8% of intra-and inter-assay coefficients of variation, respectively.…”

Section: Serum Lipid Analysismentioning

confidence: 99%

“…3 These comorbidities contribute to the increased morbidity and mortality in obese people. 4 Although there is increased effort to address this alarming health threat, success has been marginal due to various challenges. 4 It is still demanding to develop new solutions for people with specific genetic characteristics, which determine the response to a given treatment, and different product preferences to prevent weight gain or induce weight loss.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ethanol extract of Liuwei Dihuang reduces weight gain and visceral fat in obese-prone CD rats fed a high-fat diet

Nair

Zhang

Wang

2014

Exp Biol Med (Maywood)

Self Cite

View full text Add to dashboard Cite

The current study investigated the effect and mechanisms of action of Liuwei Dihuang ethanol extract (LWDH-EE) on obesity and related metabolic phenotypes in male obese-prone CD rats. The rats were fed a high-fat diet and treated with 0 (obese control), 350 (EE350), or 700 (EE700) mg/kg/d of LWDH-EE in water once a day by gavage feeding for 10 weeks. The EE700 decreased body weight after 3 weeks of the treatment and the effect was maintained throughout the remaining study period. The EE700 also significantly reduced visceral fat and improved metabolic phenotypes by lowering the serum total cholesterol (T-C), non-high-density lipoprotein cholesterol, triacylglycerol, free fatty acids (FFA), and leptin levels. The EE350 reduced epididymal fat, serum T-C, and FFA but did not significantly affect other parameters. LWDH-EE dose-dependently increased fat and carbohydrate oxidations, energy expenditure, and the relative efficiency of fat oxidation for energy expenditure. EE350 and EE700 reduced food intake only in week 5 and did not affect the accumulative food intake in every week and the entire treatment period. Taken together, the results suggest that LWDH-EE is a potential therapeutic agent for the prevention of obesity possibly through a primary action of increasing energy metabolism and expenditure, along with a possible effect of decreasing energy intake.

show abstract

Section: Serum Lipid Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ethanol extract of Liuwei Dihuang reduces weight gain and visceral fat in obese-prone CD rats fed a high-fat diet

Nair

Zhang

Wang

2014

Exp Biol Med (Maywood)

Self Cite

View full text Add to dashboard Cite

show abstract

“…The rates of obesity and overweight are continuing to grow in adults, and unfortunately that the situation has been worsening by penetrating into the child and adolescent population since two decades ago. Obesity and overweight are associated with numerous metabolic complications, which include cardiovascular disease, hyperlipidemia, insulin and leptin resistance, type 2diabetes and hypertension [1]. Thus, obesity and overweight have emerged as a serious health threat, which increasingly impacts the quality of human life and imposes a heavy burden to the health care system.…”

mentioning

confidence: 99%

Water Extract of Liuwei Dihuang Reduces Weight Gain and Visceral Fat in Obese Rats

Nair¹,

Zhang

Ji³

et al. 2013

UCMS

View full text Add to dashboard Cite

The present study was conducted to determine the effect and mechanism of action of Liuwei Dihuang (LWDH) on weight gain and visceral fat deposition in male obese-prone CD rats. The rats were divided into three groups and fed a high-fat diet (60 kcal% from fat). Two treatment groups received 600 (WE600) or 1200 (WE1200) mg/kg/d LWDH water extract dissolved in water by gavage feeding once a day for 10 weeks. The control rats were gavaged with the vehicle. Daily food intake and weekly body weight were recorded. Energy metabolism was measured using an indirect calorimeter during week 8 of the treatment. At the end of the study, rats were sacrificed. Immediately, visceral fat pads were dissected and weighed. Serum was collected for the measurement of blood lipids and hormones. It was found that WE1200 lowered body weight after 3 weeks of treatment and the effect was maintained throughout the remaining study period. WE1200 also lowered visceral fat mass, serum leptin, plasma free fatty acids and cholesterol, respectively. The energy expenditure was increased by WE1200 in both the light and dark periods. Oxygen consumption, carbon dioxide production and fat oxidation were increased in both light and dark periods, whereas carbohydrate oxidation increased only in the light period in the WE1200 group. Rats in the WE600 showed lower serum free fatty acids and leptin levels, while showing no effect on the other parameters compared to the control. These results demonstrated potential of using LWDH water extract to treat obesity and its related complications. The effect may be attributable to the increase of energy expenditure, decrease of food intake and improvement of leptin sensitivity.

show abstract

Obesity and Related Disorders

Cited by 2 publications

References 187 publications

Ethanol extract of Liuwei Dihuang reduces weight gain and visceral fat in obese-prone CD rats fed a high-fat diet

Ethanol extract of Liuwei Dihuang reduces weight gain and visceral fat in obese-prone CD rats fed a high-fat diet

Water Extract of Liuwei Dihuang Reduces Weight Gain and Visceral Fat in Obese Rats

Contact Info

Product

Resources

About